The hydrolysis reaction of (±)-2-acetamido-3-hydroxy-1-(4-nitrophenyl)-1-propanone[(±)-[STHZ]1], an intermediate of chloramphenicol, was studied and three different products were obtained respectively under ...The hydrolysis reaction of (±)-2-acetamido-3-hydroxy-1-(4-nitrophenyl)-1-propanone[(±)-[STHZ]1], an intermediate of chloramphenicol, was studied and three different products were obtained respectively under different reaction conditions. The resolution of hydrolysis product (±)-2-amino-3-hydroxy- 1-(4-nitrophenyl)-1-propanone, an intermediate of chloramphenicol, was studied and three different products were obtained respectively under different reaction conditions. The resolution of hydrolysis product (±)-2-amino-3-hydroxy- 1-(4-nitrophenyl)-1-propanone[(±)-[STHZ]3] was carried out. A process of crystallization-induced asymmetric transformation was observed and up to 76% of the optically pure enantiomer was obtained in the resolution of (±)- was carried out. A process of crystallization-induced asymmetric transformation was observed and up to 76% of the optically pure enantiomer was obtained in the resolution of (±)-3.展开更多
基金Supported by the Science and Technology Fund of Wuhan City( No.9960 0 10 16G)
文摘The hydrolysis reaction of (±)-2-acetamido-3-hydroxy-1-(4-nitrophenyl)-1-propanone[(±)-[STHZ]1], an intermediate of chloramphenicol, was studied and three different products were obtained respectively under different reaction conditions. The resolution of hydrolysis product (±)-2-amino-3-hydroxy- 1-(4-nitrophenyl)-1-propanone, an intermediate of chloramphenicol, was studied and three different products were obtained respectively under different reaction conditions. The resolution of hydrolysis product (±)-2-amino-3-hydroxy- 1-(4-nitrophenyl)-1-propanone[(±)-[STHZ]3] was carried out. A process of crystallization-induced asymmetric transformation was observed and up to 76% of the optically pure enantiomer was obtained in the resolution of (±)- was carried out. A process of crystallization-induced asymmetric transformation was observed and up to 76% of the optically pure enantiomer was obtained in the resolution of (±)-3.
