在具有不同Pareto前沿形状的优化问题上,基于参考点的高维多目标进化算法表现出较差的通用性.为了解决这个问题,提出参考点自适应调整下评价指标驱动的高维多目标进化算法(Many-objective evolutionary algorithm driven by evaluation ...在具有不同Pareto前沿形状的优化问题上,基于参考点的高维多目标进化算法表现出较差的通用性.为了解决这个问题,提出参考点自适应调整下评价指标驱动的高维多目标进化算法(Many-objective evolutionary algorithm driven by evaluation indicator under adaptive reference point adjustment, MaOEA-IAR). MaOEA-IAR提出Pareto前沿形状监测基础上的参考点自适应策略,利用该策略选择一组候选解作为初始参考点;然后通过曲线参数对参考点位置进行调整;将最终得到的能够适应不同Pareto前沿的参考点用于计算增强的反世代距离指标,基于指标值设计适应度函数作为选择标准.实验证明提出的算法在处理各种Pareto前沿形状的优化问题时能获得较好的性能,算法通用性高.展开更多
Background Nerve growth factor (NGF) is well-known for its important role in the development and maintenance of the nervous system.Along with its neurotrophic role,NGF has been detected in the testis of mouse,rat an...Background Nerve growth factor (NGF) is well-known for its important role in the development and maintenance of the nervous system.Along with its neurotrophic role,NGF has been detected in the testis of mouse,rat and human,suggesting an additional non-neurotrophic effect in the male reproductive system.The expression of β-NGF in the undescended testes (cryptorchidism) has not been detected at present.The aim of this study was to evaluate the expression of β-nerve growth factor mRNA and protein in experimental cryptorchidism.Methods A unilateral mechanical cryptorchidism model in the Sprague-Dawley rat was established and the expression of β-NGF with histologic changes in experimental cryptorchidism were investigated using one step quantitative real-time reverse transcription-polymerase chain reaction,in situ hybridization histochemistry,immunofluorescence and hematoxylin-eosin staining.Results The expression of β-NGF mRNA and protein were both significantly decreased in the development of unmarred testis and cryptorchidism-induced testis,and the decrease of β-NGF in cryptorchidism-induced testis was far greater than that in uninjured testis.Conclusion From this investigation,we confirmed a lower expression of β-NGF in undescended testes than in the development of testis.展开更多
文摘在具有不同Pareto前沿形状的优化问题上,基于参考点的高维多目标进化算法表现出较差的通用性.为了解决这个问题,提出参考点自适应调整下评价指标驱动的高维多目标进化算法(Many-objective evolutionary algorithm driven by evaluation indicator under adaptive reference point adjustment, MaOEA-IAR). MaOEA-IAR提出Pareto前沿形状监测基础上的参考点自适应策略,利用该策略选择一组候选解作为初始参考点;然后通过曲线参数对参考点位置进行调整;将最终得到的能够适应不同Pareto前沿的参考点用于计算增强的反世代距离指标,基于指标值设计适应度函数作为选择标准.实验证明提出的算法在处理各种Pareto前沿形状的优化问题时能获得较好的性能,算法通用性高.
文摘Background Nerve growth factor (NGF) is well-known for its important role in the development and maintenance of the nervous system.Along with its neurotrophic role,NGF has been detected in the testis of mouse,rat and human,suggesting an additional non-neurotrophic effect in the male reproductive system.The expression of β-NGF in the undescended testes (cryptorchidism) has not been detected at present.The aim of this study was to evaluate the expression of β-nerve growth factor mRNA and protein in experimental cryptorchidism.Methods A unilateral mechanical cryptorchidism model in the Sprague-Dawley rat was established and the expression of β-NGF with histologic changes in experimental cryptorchidism were investigated using one step quantitative real-time reverse transcription-polymerase chain reaction,in situ hybridization histochemistry,immunofluorescence and hematoxylin-eosin staining.Results The expression of β-NGF mRNA and protein were both significantly decreased in the development of unmarred testis and cryptorchidism-induced testis,and the decrease of β-NGF in cryptorchidism-induced testis was far greater than that in uninjured testis.Conclusion From this investigation,we confirmed a lower expression of β-NGF in undescended testes than in the development of testis.