目的 分析山东省威海市女性乳腺癌主要流行特征和疾病负担变化趋势,为制定乳腺癌的防控措施提供参考依据。方法 利用山东省肿瘤监测报告系统中2015-2022年威海市居民恶性肿瘤监测数据和同期人口资料,计算女性乳腺癌发病率、患病率、死...目的 分析山东省威海市女性乳腺癌主要流行特征和疾病负担变化趋势,为制定乳腺癌的防控措施提供参考依据。方法 利用山东省肿瘤监测报告系统中2015-2022年威海市居民恶性肿瘤监测数据和同期人口资料,计算女性乳腺癌发病率、患病率、死亡率、早死损失寿命年(years of life lost,YLL)率、伤残损失寿命年(years lived with disability,YLD)率、伤残调整寿命年(disability adjusted of life years,DALY)率及相应的调整率,采用Joinpoint Regression Program 4.9.1.0软件计算率的年度变化百分比,并分析女性乳腺癌主要流行特征及疾病负担变化情况。结果 2015-2022年威海市女性乳腺癌粗发病率为50.25/10万~79.80/10万,调整率为31.93/10万~49.03/10万;粗患病率为137.13/10万~499.03/10万,调整率为85.90/10万~276.37/10万;粗死亡率为8.40/10万~12.21/10万,调整率为5.45/10万~7.52/10万,粗发病率、粗患病率及相应的调整率的上升均有统计学意义(t=8.205、t=21.681、t=5.705、t=20.219,均P <0.05)。乳腺癌发病率总体以45~54岁年龄组最高,除0~24岁年龄组外,发病率随年龄增长而升高。其中45~54岁、55~64岁、≥75岁年龄组发病率的上升均有统计学意义(t=7.133、t=4.962、t=4.248,均P <0.05)。2015-2022年威海市女性乳腺癌DALY率为1.76‰~2.30‰,调整率为1.29‰~1.65‰;YLL率为1.28‰~1.75‰,调整率为0.87‰~1.28‰;YLD率为0.44‰~0.67‰,调整率为0.31‰~0.46‰,其中YLD率和调整率均呈上升趋势且有统计学意义(t=6.876、t=5.313,均P <0.05)。DALY率总体以45~54岁年龄组最高;45~54岁、55~64岁年龄组的YLD率以及≥75岁年龄组的YLD率、YLL率均呈上升趋势且有统计学意义(t=7.283、t=4.793,t=4.072、t=4.273,均P <0.05)。结论 威海市女性乳腺癌年度粗发病率和YLD率均呈上升趋势,更多是非人口因素作用的结果。年度死亡率和健康负担总体保持稳定。高龄女性面临着乳腺癌发病率和死亡率双升高的威胁,应作为乳腺癌筛查项目的重点关注人群,并根据环境及行为生活方式方面的乳腺癌危险因素有针对性地开展科普宣传和健康教育。持续升高的患病率加重了患者、家庭和社会的经济负担,是导致疾病负担加重的主要原因,应进一步研究降低与医疗活动有关经济支出的有效方式。展开更多
In December 2019,an outbreak of COVID-19 occurred in Wuhan City in Hubei Province of China.Neighboring Hunan Province launched a Level 1 public health emergency response on January 24,2020.Chenzhou City,located in the...In December 2019,an outbreak of COVID-19 occurred in Wuhan City in Hubei Province of China.Neighboring Hunan Province launched a Level 1 public health emergency response on January 24,2020.Chenzhou City,located in the southernmost part of Hunan Province,bordering Guangdong Province and Jiangxi Province,has formed an agglomeration zone for processing trade and laborintensive industries.At the beginning of the outbreak,most businesses in this region suspended production,and they resumed production gradually after February 10,2020.展开更多
In this study, we searched multiple databases for all relevant original articles (1996-2013). To investigate blood lead levels (BLL) and possible risk factors for lead exposure among children in China A total of 388 a...In this study, we searched multiple databases for all relevant original articles (1996-2013). To investigate blood lead levels (BLL) and possible risk factors for lead exposure among children in China A total of 388 articles met our inclusion criteria. The overall geometric mean (GM) BLL was 71 μg/L, and the prevalence of elevated BLL (EBLL, defined as BLL ≥100 μg/L) was 18.48% among children. The prevalence of EBLL remained significantly higher among boys. In children less than 6 years of age, there were significantly increasing trends in both BLL and prevalence of EBLL in an age-dependent manner. The ban on leaded gasoline significantly reduced the BLL as well as EBLL prevalence; however, children whose parents had lower educational levels or were exposed to lead in the workplace had a higher EBLL prevalence. Despite its decline over time, the average BLL among children in China remains higher than the average level most recently reported in the United States. Childhood lead poisoning remains a public health problem in China.展开更多
文摘目的 分析山东省威海市女性乳腺癌主要流行特征和疾病负担变化趋势,为制定乳腺癌的防控措施提供参考依据。方法 利用山东省肿瘤监测报告系统中2015-2022年威海市居民恶性肿瘤监测数据和同期人口资料,计算女性乳腺癌发病率、患病率、死亡率、早死损失寿命年(years of life lost,YLL)率、伤残损失寿命年(years lived with disability,YLD)率、伤残调整寿命年(disability adjusted of life years,DALY)率及相应的调整率,采用Joinpoint Regression Program 4.9.1.0软件计算率的年度变化百分比,并分析女性乳腺癌主要流行特征及疾病负担变化情况。结果 2015-2022年威海市女性乳腺癌粗发病率为50.25/10万~79.80/10万,调整率为31.93/10万~49.03/10万;粗患病率为137.13/10万~499.03/10万,调整率为85.90/10万~276.37/10万;粗死亡率为8.40/10万~12.21/10万,调整率为5.45/10万~7.52/10万,粗发病率、粗患病率及相应的调整率的上升均有统计学意义(t=8.205、t=21.681、t=5.705、t=20.219,均P <0.05)。乳腺癌发病率总体以45~54岁年龄组最高,除0~24岁年龄组外,发病率随年龄增长而升高。其中45~54岁、55~64岁、≥75岁年龄组发病率的上升均有统计学意义(t=7.133、t=4.962、t=4.248,均P <0.05)。2015-2022年威海市女性乳腺癌DALY率为1.76‰~2.30‰,调整率为1.29‰~1.65‰;YLL率为1.28‰~1.75‰,调整率为0.87‰~1.28‰;YLD率为0.44‰~0.67‰,调整率为0.31‰~0.46‰,其中YLD率和调整率均呈上升趋势且有统计学意义(t=6.876、t=5.313,均P <0.05)。DALY率总体以45~54岁年龄组最高;45~54岁、55~64岁年龄组的YLD率以及≥75岁年龄组的YLD率、YLL率均呈上升趋势且有统计学意义(t=7.283、t=4.793,t=4.072、t=4.273,均P <0.05)。结论 威海市女性乳腺癌年度粗发病率和YLD率均呈上升趋势,更多是非人口因素作用的结果。年度死亡率和健康负担总体保持稳定。高龄女性面临着乳腺癌发病率和死亡率双升高的威胁,应作为乳腺癌筛查项目的重点关注人群,并根据环境及行为生活方式方面的乳腺癌危险因素有针对性地开展科普宣传和健康教育。持续升高的患病率加重了患者、家庭和社会的经济负担,是导致疾病负担加重的主要原因,应进一步研究降低与医疗活动有关经济支出的有效方式。
基金funded by the Innovation and Entrepreneurship Training Program Fund for College Students in Hunan Province[2020-3677]
文摘In December 2019,an outbreak of COVID-19 occurred in Wuhan City in Hubei Province of China.Neighboring Hunan Province launched a Level 1 public health emergency response on January 24,2020.Chenzhou City,located in the southernmost part of Hunan Province,bordering Guangdong Province and Jiangxi Province,has formed an agglomeration zone for processing trade and laborintensive industries.At the beginning of the outbreak,most businesses in this region suspended production,and they resumed production gradually after February 10,2020.
基金supported by The National Natural Science Foundation of China(No.81172628)the Fundamental Research Funds for the Central Universities(No.2014305020201)
文摘In this study, we searched multiple databases for all relevant original articles (1996-2013). To investigate blood lead levels (BLL) and possible risk factors for lead exposure among children in China A total of 388 articles met our inclusion criteria. The overall geometric mean (GM) BLL was 71 μg/L, and the prevalence of elevated BLL (EBLL, defined as BLL ≥100 μg/L) was 18.48% among children. The prevalence of EBLL remained significantly higher among boys. In children less than 6 years of age, there were significantly increasing trends in both BLL and prevalence of EBLL in an age-dependent manner. The ban on leaded gasoline significantly reduced the BLL as well as EBLL prevalence; however, children whose parents had lower educational levels or were exposed to lead in the workplace had a higher EBLL prevalence. Despite its decline over time, the average BLL among children in China remains higher than the average level most recently reported in the United States. Childhood lead poisoning remains a public health problem in China.
