乙型肝炎病毒(Hepatitis B virus,HBV)感染呈世界性流行,是引起慢性肝炎、肝硬化、肝癌的主要原因,然而,当前的干扰素与核苷和核苷酸类药物等HBV治疗药物不能显著提高功能性治愈的比例。随着对HBV感染宿主细胞过程不断深入的了解,针对...乙型肝炎病毒(Hepatitis B virus,HBV)感染呈世界性流行,是引起慢性肝炎、肝硬化、肝癌的主要原因,然而,当前的干扰素与核苷和核苷酸类药物等HBV治疗药物不能显著提高功能性治愈的比例。随着对HBV感染宿主细胞过程不断深入的了解,针对上述过程中不同的作用靶点,对抗HBV新药的研发有了很大的进展,本文将主要对新药的研究进行简要总结。展开更多
Introduction Inflammatory bowel diseases(IBD),such as Crohn’s disease(CD)and ulcerative colitis(UC),are a group of chronic inflammatory disorders of the gastrointestinal tract[1-2].The symptoms of IBD include abdomin...Introduction Inflammatory bowel diseases(IBD),such as Crohn’s disease(CD)and ulcerative colitis(UC),are a group of chronic inflammatory disorders of the gastrointestinal tract[1-2].The symptoms of IBD include abdominal pain,diarrhea,and bloody stool.IBD affects a patient’s quality of life severely,due in part to its frequent recurrence.Colorectal cancer(CRC)is a malignancy in the colon or rectum with symptoms including bloody stool,changes in展开更多
文摘乙型肝炎病毒(Hepatitis B virus,HBV)感染呈世界性流行,是引起慢性肝炎、肝硬化、肝癌的主要原因,然而,当前的干扰素与核苷和核苷酸类药物等HBV治疗药物不能显著提高功能性治愈的比例。随着对HBV感染宿主细胞过程不断深入的了解,针对上述过程中不同的作用靶点,对抗HBV新药的研发有了很大的进展,本文将主要对新药的研究进行简要总结。
基金supported by Funds from Talents’Start-up Fund of Gannan Medical University(QD201404,LIU Zhiping)Natural Science Foundation of Jiangxi Province(20151512040424,LIU Zhi-ping)
文摘Introduction Inflammatory bowel diseases(IBD),such as Crohn’s disease(CD)and ulcerative colitis(UC),are a group of chronic inflammatory disorders of the gastrointestinal tract[1-2].The symptoms of IBD include abdominal pain,diarrhea,and bloody stool.IBD affects a patient’s quality of life severely,due in part to its frequent recurrence.Colorectal cancer(CRC)is a malignancy in the colon or rectum with symptoms including bloody stool,changes in
