临床分析:强直性脊柱炎患者的血脂谱及其与疾病活动关系

目的 研究强直性脊柱炎患者的血脂谱特点及其与疾病活动的关系.方法 比较强直性脊柱炎与健康体检者的血脂谱、活动期与稳定期患者的血脂谱,并分析其与疾病活动的关系.结果 与健康体检者比,强直性脊柱炎患者的总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)减低,年龄大,差异有统计学意义(P=0.0300,P<0.0001,P=0.0191);低密度脂蛋白胆固醇(LDL-C)、身体质量指数(BMI)、性别比差异无统计学意义(P>0.05).强直性脊柱炎活动组与稳定组相比,脂蛋白a(LP(a))、血沉(ESR)、C反应蛋白(CRP)增高(P=0.0059,P<0.0001,P=0.0005),TC、TG、HDL-C、LDL-C、载脂蛋白AⅠ(apoA-Ⅰ)、载脂蛋白B(apoB)、BMI差异无统计学意义(P>0.05).LP(a)与疾病活动有秩相关关系(rs=0.33228,P=0.0362);Logistic回归分析示LP(a)对疾病活动的影响差异无统计学意义(回归系数β=0.00373,OR=1.004,95%CI:0.997~1.011,P=0.2955).结论 强直性脊柱炎患者的TC、HDL-C水平低,活动期的强直性脊柱炎患者LP(a)、ESR、CRP值增高,LP(a)与强直性脊柱炎疾病活动存在秩相关关系,但不能根据其数值推测疾病活动度.

A Note on Preemptive Scheduling with Multiple Maintenance Activities to Minimize the Total Late Work

We study the single-machine preemptive scheduling problem with multiple maintenance activities to minimize the total late work,in which the jobs must be processed in the time space not occupied by the maintenance intervals.For this problem,we present a polynomial algorithm to determine the optimal schedule and establish a formula expression to the optimal value.Moreover,our result is used to correct some minor errors in the literature related to the single-machine(preemptive or non-preemptive)scheduling with one maintenance activity to minimize the total late work.