Background Many postmenopausal women with low-density lipoprotein-cholesterol(LDL-C)<130 mg/dL from Chaoshan region suffer from coronary artery diseases,especially severe coronary artery lesions. However,few studie...Background Many postmenopausal women with low-density lipoprotein-cholesterol(LDL-C)<130 mg/dL from Chaoshan region suffer from coronary artery diseases,especially severe coronary artery lesions. However,few studies specifically focused on the cardiovascular risks of this subgroup of postmenopausal women.Methods A total of 270 postmenopausal women with LDL-C<130 mg/dL from Chaoshan region were enrolled in this cohort study. Patients with angiographically proven coronary artery diseases(CAD)served as CAD group(n=174),while the ones with angiographically proven normal coronary arteries served as Control group(n=96).Results The age of CAD group(68.5±8.4 years)was older than that of Control group(60.0±6.9 years)(P<0.001). The prevalence rates of hypertension,diabetes mellitus(DM)and hyperuricemia in CAD group were significantly higher than those of Control group(P<0.05 for both comparisons). The serum level of uric acid(UA)in CAD group was significantly higher than that in Control group(P<0.001). Age,DM and UA were independent cardiovascular predictors of postmenopausal women with LDL-C<130 mg/dL from Chaoshan Region[ORAGE:1.140(95%CI:1.095-1.188),ORDM:2.740(95%CI:1.368-5.486),ORUA:1.003(95%CI:1.001-1.006),PAGE<00.001,PDM=0.004,PUA=0.019]. Conclusions Postmenopausal women with LDL-C<130 mg/dL complicating CAD are elder with higher prevalence rates of hyperuricemia and DM. Age,DM and UA are considered as independent cardiovascular risk factors in the postmenopausal women with LDL-C <130 mg/dL from Chaoshan Region of China.[S Chin J Cardiol 2019;20(2):79-85]展开更多
文摘Background Many postmenopausal women with low-density lipoprotein-cholesterol(LDL-C)<130 mg/dL from Chaoshan region suffer from coronary artery diseases,especially severe coronary artery lesions. However,few studies specifically focused on the cardiovascular risks of this subgroup of postmenopausal women.Methods A total of 270 postmenopausal women with LDL-C<130 mg/dL from Chaoshan region were enrolled in this cohort study. Patients with angiographically proven coronary artery diseases(CAD)served as CAD group(n=174),while the ones with angiographically proven normal coronary arteries served as Control group(n=96).Results The age of CAD group(68.5±8.4 years)was older than that of Control group(60.0±6.9 years)(P<0.001). The prevalence rates of hypertension,diabetes mellitus(DM)and hyperuricemia in CAD group were significantly higher than those of Control group(P<0.05 for both comparisons). The serum level of uric acid(UA)in CAD group was significantly higher than that in Control group(P<0.001). Age,DM and UA were independent cardiovascular predictors of postmenopausal women with LDL-C<130 mg/dL from Chaoshan Region[ORAGE:1.140(95%CI:1.095-1.188),ORDM:2.740(95%CI:1.368-5.486),ORUA:1.003(95%CI:1.001-1.006),PAGE<00.001,PDM=0.004,PUA=0.019]. Conclusions Postmenopausal women with LDL-C<130 mg/dL complicating CAD are elder with higher prevalence rates of hyperuricemia and DM. Age,DM and UA are considered as independent cardiovascular risk factors in the postmenopausal women with LDL-C <130 mg/dL from Chaoshan Region of China.[S Chin J Cardiol 2019;20(2):79-85]