目的:探讨眶隔筋膜瓣结合额肌瓣悬吊术对重度上睑下垂的远期疗效及屈光状态的影响。方法:选取2016年8月-2017年8月笔者医院收治的重度上睑下垂患者84例(128眼),随机分为两组,对照组应用单切口额肌筋膜瓣悬吊术治疗,研究组应用眶隔筋膜...目的:探讨眶隔筋膜瓣结合额肌瓣悬吊术对重度上睑下垂的远期疗效及屈光状态的影响。方法:选取2016年8月-2017年8月笔者医院收治的重度上睑下垂患者84例(128眼),随机分为两组,对照组应用单切口额肌筋膜瓣悬吊术治疗,研究组应用眶隔筋膜瓣联合额肌瓣悬吊术治疗。比较两组矫正率、上睑回缩量及双侧眼睑对称程度。结果:两组总矫正率比较(100.0%vs98.4%),差异无统计学意义(P>0.05),但研究组完全矫正率为75.0%明显多于对照组的56.3%,差异有统计学意义(P<0.05)。术后6个月,研究组患者的上睑回缩量明显低于对照组[(0.16±0.02)mm vs (0.41±0.03)mm,P<0.05];研究组患者的上睑缘恢复对称程度、上睑缘形态及眼睑闭合程度均优于对照组,差异有统计学意义(P<0.05)。两组患者的角膜屈光度和角膜散光度比较,差异无统计学意义(P>0.05)。结论:在针对重度上睑下垂的治疗过程当中,应用眶隔筋膜瓣联合额肌瓣悬吊术的治疗效果理想,临床上应当进一步推广应用。展开更多
目的分析膨胀期及过熟期白内障继发青光眼患者的人工晶体植入术的应用效果。方法研究时间:2015年5月—2017年1月,研究对象;40例该院收治的白内障继发青光眼患者,按照随机数字表法将其分为对照组(n=20)、实验组(n=20),对照组:给予二期人...目的分析膨胀期及过熟期白内障继发青光眼患者的人工晶体植入术的应用效果。方法研究时间:2015年5月—2017年1月,研究对象;40例该院收治的白内障继发青光眼患者,按照随机数字表法将其分为对照组(n=20)、实验组(n=20),对照组:给予二期人工晶体植入双襻治疗,实验组:二期人工晶体植入四襻治疗,观察两组患者治疗后的治疗效果、眼压、并发症发生率。结果治疗效果对比实验组高于对照组(85.0%vs 55.0%,χ~2=4.286,P<0.05)。眼压对比实验组低于对照组(7.01±4.13)mmHg vs (9.49±2.19)mmHg,(t=2.371,P<0.05)。并发症发生率对比实验组低于对照组(10.0%vs 40.0%,χ~2=4.80%,P<0.05)。结论膨胀期及过熟期白内障继发青光眼患者的人工晶体植入术的应用效果显著,治疗后患者视力情况恢复较好,值得临床推广借鉴。展开更多
Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 mice.Methods Forty-five 3-month-old male APP/PS1 mice were divid...Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 mice.Methods Forty-five 3-month-old male APP/PS1 mice were divided into 3 groups using a random number table(n=15 per group),including a model group(MG),a liraglutide group(LG)and a BXD group(BG).Fifteen 3-month-old male C57BL/6J wild-type mice were used as the control group(CG).Mice in the BG were administered BXD granules by gavage at a dose of 6 g/(kg·d)for 3 months,while mice in the LG were injected intraperitoneally once daily with Liraglutide Injection(25 nmol/kg)for 3 months.Firstly,liquid chromatography with tandem-mass spectrometry was used to analyze the active components of BXD granules and the medicated serum of BXD.Then,the cognitive deficits,Aβpathological change and synaptic plasticity markers,including synaptophysin(SYP)and postsynaptic density protein 95(PSD95),were measured in APP/PS1 mice.Brain glucose uptake was detected by micropositron emission tomography.Intestinal microbial constituents were detected by 16S rRNA sequencing.The levels of intestinal glucagon-like peptide 1(GLP-1)and cerebral GLP-1 receptor(GLP-1R),as well as the phosphoinositide-3-kinase/protein kinase B/glycogen synthase kinase-3β(PI3K/Akt/GSK3β)insulin signaling pathway were determined by immunohistochemical(IHC)staining and Western blot analysis,respectively.Results BXD ameliorated cognitive deficits and Aβpathological features(P<0.01).The expressions of SYP and PSD95 in the BG were higher than those in the MG(P<0.01).Brain glucose uptake in the BG was higher than that in the MG(P<0.01).The intestinal microbial composition in the BG was partially reversed.The levels of intestinal GLP-1 in the BG were higher than those in the MG(P<0.01).Compared with the MG,the expression levels of hippocampal GLP-1R,Akt,PI3K and p-PI3K in the BG were significantly increased(P<0.01),while the levels of GSK3βwere reduced(P<0.01).Conclusion BXD exhibited protective effects against Alzheimer’s disease by regulating the gut microbiota/GLP-1/GLP-1R,enhancing PI3K/Akt/GSK3βinsulin signaling pathway,and improving brain glucose metabolism.展开更多
文摘目的:探讨眶隔筋膜瓣结合额肌瓣悬吊术对重度上睑下垂的远期疗效及屈光状态的影响。方法:选取2016年8月-2017年8月笔者医院收治的重度上睑下垂患者84例(128眼),随机分为两组,对照组应用单切口额肌筋膜瓣悬吊术治疗,研究组应用眶隔筋膜瓣联合额肌瓣悬吊术治疗。比较两组矫正率、上睑回缩量及双侧眼睑对称程度。结果:两组总矫正率比较(100.0%vs98.4%),差异无统计学意义(P>0.05),但研究组完全矫正率为75.0%明显多于对照组的56.3%,差异有统计学意义(P<0.05)。术后6个月,研究组患者的上睑回缩量明显低于对照组[(0.16±0.02)mm vs (0.41±0.03)mm,P<0.05];研究组患者的上睑缘恢复对称程度、上睑缘形态及眼睑闭合程度均优于对照组,差异有统计学意义(P<0.05)。两组患者的角膜屈光度和角膜散光度比较,差异无统计学意义(P>0.05)。结论:在针对重度上睑下垂的治疗过程当中,应用眶隔筋膜瓣联合额肌瓣悬吊术的治疗效果理想,临床上应当进一步推广应用。
文摘目的分析膨胀期及过熟期白内障继发青光眼患者的人工晶体植入术的应用效果。方法研究时间:2015年5月—2017年1月,研究对象;40例该院收治的白内障继发青光眼患者,按照随机数字表法将其分为对照组(n=20)、实验组(n=20),对照组:给予二期人工晶体植入双襻治疗,实验组:二期人工晶体植入四襻治疗,观察两组患者治疗后的治疗效果、眼压、并发症发生率。结果治疗效果对比实验组高于对照组(85.0%vs 55.0%,χ~2=4.286,P<0.05)。眼压对比实验组低于对照组(7.01±4.13)mmHg vs (9.49±2.19)mmHg,(t=2.371,P<0.05)。并发症发生率对比实验组低于对照组(10.0%vs 40.0%,χ~2=4.80%,P<0.05)。结论膨胀期及过熟期白内障继发青光眼患者的人工晶体植入术的应用效果显著,治疗后患者视力情况恢复较好,值得临床推广借鉴。
基金Supported by the Special Fund for Basic Scientific Research Operating Fees of Central Universities(No.2019-BUCMXJKY018)。
文摘Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 mice.Methods Forty-five 3-month-old male APP/PS1 mice were divided into 3 groups using a random number table(n=15 per group),including a model group(MG),a liraglutide group(LG)and a BXD group(BG).Fifteen 3-month-old male C57BL/6J wild-type mice were used as the control group(CG).Mice in the BG were administered BXD granules by gavage at a dose of 6 g/(kg·d)for 3 months,while mice in the LG were injected intraperitoneally once daily with Liraglutide Injection(25 nmol/kg)for 3 months.Firstly,liquid chromatography with tandem-mass spectrometry was used to analyze the active components of BXD granules and the medicated serum of BXD.Then,the cognitive deficits,Aβpathological change and synaptic plasticity markers,including synaptophysin(SYP)and postsynaptic density protein 95(PSD95),were measured in APP/PS1 mice.Brain glucose uptake was detected by micropositron emission tomography.Intestinal microbial constituents were detected by 16S rRNA sequencing.The levels of intestinal glucagon-like peptide 1(GLP-1)and cerebral GLP-1 receptor(GLP-1R),as well as the phosphoinositide-3-kinase/protein kinase B/glycogen synthase kinase-3β(PI3K/Akt/GSK3β)insulin signaling pathway were determined by immunohistochemical(IHC)staining and Western blot analysis,respectively.Results BXD ameliorated cognitive deficits and Aβpathological features(P<0.01).The expressions of SYP and PSD95 in the BG were higher than those in the MG(P<0.01).Brain glucose uptake in the BG was higher than that in the MG(P<0.01).The intestinal microbial composition in the BG was partially reversed.The levels of intestinal GLP-1 in the BG were higher than those in the MG(P<0.01).Compared with the MG,the expression levels of hippocampal GLP-1R,Akt,PI3K and p-PI3K in the BG were significantly increased(P<0.01),while the levels of GSK3βwere reduced(P<0.01).Conclusion BXD exhibited protective effects against Alzheimer’s disease by regulating the gut microbiota/GLP-1/GLP-1R,enhancing PI3K/Akt/GSK3βinsulin signaling pathway,and improving brain glucose metabolism.
