目的对1例ABw亚型患者进行A型血浆置换后血型血清学变化以及是否发生溶血反应进行回顾性调查。方法使用微柱凝胶技术、微柱玻璃珠技术、盐水试管法、吸收放散等血型血清学方法及分子生物学方式进行ABO血型鉴定和基因分型,对患者血浆置...目的对1例ABw亚型患者进行A型血浆置换后血型血清学变化以及是否发生溶血反应进行回顾性调查。方法使用微柱凝胶技术、微柱玻璃珠技术、盐水试管法、吸收放散等血型血清学方法及分子生物学方式进行ABO血型鉴定和基因分型,对患者血浆置换前后实验室检查结果进行分析。结果该患者于行2000 mL A型血浆置换后转入本院,d 2检测正反定型相符;d 3检测反定B细胞凝集强度为±~1+,正反定型不符。经试管法、人源抗-B吸收放散试验确认存在B抗原,分子生物学鉴定为ABw03型。患者用A型血浆进行血浆置换后,血红蛋白、血小板计数均一过性下降,肌酐一过性轻度上升,谷丙转氨酶、谷草转氨酶持续下降,总胆红素和间接胆红素一过性下降后上升,提示存在轻微的溶血性输血反应。结论ABO亚型患者含弱A或B抗原,输注大量血浆可能引起溶血性输血反应。应严格按照ABO血型正反定型标准判断血型结果,对弱凝集采取额外实验室检查并结合分子生物学技术进行正确的判断和处理,可以减少ABO亚型的漏检,减少输血反应的发生。展开更多
主导逻辑作为“管理工具”具有“信息过滤器”的实践功效,那么“信息过滤器”为什么能够发挥和如何发挥实践功效?主导逻辑除了“过滤器”还有其他“管理工具”实践功效吗?对这些问题的研究关系到主导逻辑如何从一个“模糊抽象”的概念...主导逻辑作为“管理工具”具有“信息过滤器”的实践功效,那么“信息过滤器”为什么能够发挥和如何发挥实践功效?主导逻辑除了“过滤器”还有其他“管理工具”实践功效吗?对这些问题的研究关系到主导逻辑如何从一个“模糊抽象”的概念转变为一个可以指导企业实践的“管理工具”。本文聚焦于成功实施成本领先战略的案例企业T M T主导逻辑,依据主导逻辑的载体——“管理认知”的“关注焦点”“因果逻辑”两个维度,运用因果映射法使T M T成本领先战略主导逻辑的信息“关注焦点”和“因果逻辑”可视化,结合主导逻辑因果映射图特征分析和T M T主导逻辑与成本领先战略行动决策、成本领先战略目标关系分析,最终分析出了除“信息过滤器”之外还存在“信息反应器”管理实践功效,并且归纳分析了TMT竞争战略主导逻辑的“五点三链”组成结构,进而回答了T M T竞争战略主导逻辑作为“管理工具”为什么能够发挥实践功效的作用机理,从理论上挖掘和释放主导逻辑作为管理工具的潜在价值,同时对企业实践也有重要启迪。展开更多
Efficient separation of C4 olefins is of critical importance and a challenging task in petrochemical industry. Covalent organic frameworks(COFs) could be used as promising candidates for membrane-based isobutene/1,3-b...Efficient separation of C4 olefins is of critical importance and a challenging task in petrochemical industry. Covalent organic frameworks(COFs) could be used as promising candidates for membrane-based isobutene/1,3-butadiene(i-C4H8/C4H6) separation. Owing to large amounts of COFs appearing, however, the rapid prediction of optimal COFs is imperative before experimental efforts. In this work, we combine molecular simulation and machine learning to study COF membranes for efficient isolation of i-C4H8 over C4H6. Using molecular simulation, four potential COF membranes, which possess both high membrane performance score (MPS) value and moderate membrane selectivity were screened out and the mechanism of membrane separation further revealed is an adsorption dominated process. Further, random forest(RF) model with high prediction accuracy(R2>0.84) was obtained and used for elucidating key factors in controlling the membrane selectivity and i-C4H8 permeability. Ultimately, the optimal COF features were obtained through structure-performance relationship study. Our results may trigger experimental efforts to accelerate the design of novel COFs with better i-C4H8/C4H6separation performance.展开更多
文摘目的对1例ABw亚型患者进行A型血浆置换后血型血清学变化以及是否发生溶血反应进行回顾性调查。方法使用微柱凝胶技术、微柱玻璃珠技术、盐水试管法、吸收放散等血型血清学方法及分子生物学方式进行ABO血型鉴定和基因分型,对患者血浆置换前后实验室检查结果进行分析。结果该患者于行2000 mL A型血浆置换后转入本院,d 2检测正反定型相符;d 3检测反定B细胞凝集强度为±~1+,正反定型不符。经试管法、人源抗-B吸收放散试验确认存在B抗原,分子生物学鉴定为ABw03型。患者用A型血浆进行血浆置换后,血红蛋白、血小板计数均一过性下降,肌酐一过性轻度上升,谷丙转氨酶、谷草转氨酶持续下降,总胆红素和间接胆红素一过性下降后上升,提示存在轻微的溶血性输血反应。结论ABO亚型患者含弱A或B抗原,输注大量血浆可能引起溶血性输血反应。应严格按照ABO血型正反定型标准判断血型结果,对弱凝集采取额外实验室检查并结合分子生物学技术进行正确的判断和处理,可以减少ABO亚型的漏检,减少输血反应的发生。
文摘主导逻辑作为“管理工具”具有“信息过滤器”的实践功效,那么“信息过滤器”为什么能够发挥和如何发挥实践功效?主导逻辑除了“过滤器”还有其他“管理工具”实践功效吗?对这些问题的研究关系到主导逻辑如何从一个“模糊抽象”的概念转变为一个可以指导企业实践的“管理工具”。本文聚焦于成功实施成本领先战略的案例企业T M T主导逻辑,依据主导逻辑的载体——“管理认知”的“关注焦点”“因果逻辑”两个维度,运用因果映射法使T M T成本领先战略主导逻辑的信息“关注焦点”和“因果逻辑”可视化,结合主导逻辑因果映射图特征分析和T M T主导逻辑与成本领先战略行动决策、成本领先战略目标关系分析,最终分析出了除“信息过滤器”之外还存在“信息反应器”管理实践功效,并且归纳分析了TMT竞争战略主导逻辑的“五点三链”组成结构,进而回答了T M T竞争战略主导逻辑作为“管理工具”为什么能够发挥实践功效的作用机理,从理论上挖掘和释放主导逻辑作为管理工具的潜在价值,同时对企业实践也有重要启迪。
基金supported by the National Natural Science Foundation of China (Nos.22038010,21878229,22108202,22008179,21978212,22078024)the Science and Technology Plans of Tianjin,China(Nos.19PTSYJC00020,20ZYJDJC00110,21ZYJDJC00040).
文摘Efficient separation of C4 olefins is of critical importance and a challenging task in petrochemical industry. Covalent organic frameworks(COFs) could be used as promising candidates for membrane-based isobutene/1,3-butadiene(i-C4H8/C4H6) separation. Owing to large amounts of COFs appearing, however, the rapid prediction of optimal COFs is imperative before experimental efforts. In this work, we combine molecular simulation and machine learning to study COF membranes for efficient isolation of i-C4H8 over C4H6. Using molecular simulation, four potential COF membranes, which possess both high membrane performance score (MPS) value and moderate membrane selectivity were screened out and the mechanism of membrane separation further revealed is an adsorption dominated process. Further, random forest(RF) model with high prediction accuracy(R2>0.84) was obtained and used for elucidating key factors in controlling the membrane selectivity and i-C4H8 permeability. Ultimately, the optimal COF features were obtained through structure-performance relationship study. Our results may trigger experimental efforts to accelerate the design of novel COFs with better i-C4H8/C4H6separation performance.
