Biogeographical barriers to gene flow are central to plant phylogeography.In East Asia,plant distribution is greatly influenced by two phylogeographic breaks,the Mekong-Salween Divide and Tanaka-Kaiyong Line,however,f...Biogeographical barriers to gene flow are central to plant phylogeography.In East Asia,plant distribution is greatly influenced by two phylogeographic breaks,the Mekong-Salween Divide and Tanaka-Kaiyong Line,however,few studies have investigated how these barriers affect the genetic diversity of species that are distributed across both.Here we used 14 microsatellite loci and four chloroplast DNA fragments to examine genetic diversity and distribution patterns of 49 populations of Populus rotundifolia,a species that spans both the Mekong-Salween Divide and the Tanaka-Kaiyong Line in southwestern China.Demographic and migration hypotheses were tested using coalescent-based approaches.Limited historical gene flow was observed between the western and eastern groups of P.rotundifolia,but substantial flow occurred across both the Mekong-Salween Divide and Tanaka-Kaiyong Line,manifesting in clear admixture and high genetic diversity in the central group.Wind-borne pollen and seeds may have facilitated the dispersal of P.rotundifolia following prevalent northwest winds in the spring.We also found that the Hengduan Mountains,where multiple genetic barriers were detected,acted on the whole as a barrier between the western and eastern groups of P.rotundifolia.Ecological niche modeling suggested that P.rotundifolia has undergone range expansion since the last glacial maximum,and demographic reconstruction indicated an earlier population expansion around 600 Ka.The phylogeographic pattern of P.rotundifolia reflects the interplay of biological traits,wind patterns,barriers,niche differentiation,and Quaternary climate history.This study emphasizes the need for multiple lines of evidence in understanding the Quaternary evolution of plants in topographically complex areas.展开更多
Rotavirus is one of the pathogenic causes that induce diarrhea in young animals, especially piglets, worldwide. However, nowadays, there is no specific drug available to treat the disease, and the related vaccines hav...Rotavirus is one of the pathogenic causes that induce diarrhea in young animals, especially piglets, worldwide. However, nowadays, there is no specific drug available to treat the disease, and the related vaccines have no obvious efficiency in some countries. Via analyzing the pathogenesis of rotavirus, it inducing diarrhea is mainly due to disturb enteric nervous system, destroy gut mucosal integrity, induce intracellular electrolyte imbalance, and impair gut microbiota and immunity. Many studies have already proved that prebiotics and probiotics can mitigate the damage and diarrhea induced by rotavirus infection in hosts. Based on these, the current review summarizes and discusses the effects and mechanisms of prebiotics and probiotics on rotavirus-induced diarrhea in piglets. This information will highlight the basis for the swine production utilization of prebiotics and probiotics in the prevention or treatment of rotavirus infection in the future.展开更多
Endangered species generally have small populations with low genetic diversity and a high genetic load.Thuja sutchuenensis is an endangered conifer endemic to southwestern China.It was once considered extinct in the w...Endangered species generally have small populations with low genetic diversity and a high genetic load.Thuja sutchuenensis is an endangered conifer endemic to southwestern China.It was once considered extinct in the wild,but in 1999 was rediscovered.However,little is known about its genetic load.We collected 67 individuals from five wild,isolated T.sutchuenensis populations,and used 636,151 SNPs to analyze the level of genetic diversity and genetic load in T.sutchuenensis to delineate the conservation units of T.sutchuenensis,based on whole transcriptome sequencing data,as well as target capture sequencing data.We found that populations of T.sutchuenensis could be divided into three groups.These groups had low levels genetic diversity and were moderately genetically differentiated.Our findings also indicate that T.sutchuenensis suffered two severe bottlenecks around the Last Glaciation Period and Last Glacial Maximum.Among Thuja species,T.sutchuenensis presented the lowest genetic load and hence might have purged deleterious mutations efficiently through purifying selection.However,distribution of fitness effects analysis indicated a high extinction risk for T.sutchuenensis.Multiple lines of evidence identified three management units for T.sutchuenensis.Although T.sutchuenensis possesses a low genetic load,low genetic diversity,suboptimal fitness,and anthropogenic pressures all present an extinction risk for this rare conifer.This might also hold true for many endangered plant species in the mountains all over the world.展开更多
Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy,but fibrotic matrix severely blocks senescence inducers penetration and immune cells infiltration.Herein,we designed a ca...Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy,but fibrotic matrix severely blocks senescence inducers penetration and immune cells infiltration.Herein,we designed a cancer-associated fibroblasts(CAFs)triggered structure-transformable nano-assembly(HSD-P@V),which can directionally deliver valsartan(Val,CAFs regulator)and doxorubicin(DOX,senescence inducer)to the specific targets.In detail,DOX is conjugated with hyaluronic acid(HA)via diselenide bonds(Se-Se)to form HSD micelles,while CAFs-sensitive peptide is grafted onto the HSD to form a hydrophilic polymer,which is coated on Val nanocrystals(VNs)surface for improving the stability and achieving responsive release.Once arriving at tumor microenvironment and touching CAFs,HSD-P@V disintegrates into VNs and HSD micelles due to sensitive peptide detachment.VNs can degrade the extracellularmatrix,leading to the enhanced penetration of HSD.HSD targets tumor cells,releases DOX to induce senescence,and recruits effector immune cells.Furthermore,senescent cells are cleared by the recruited immune cells to finish the integrated anti-tumor therapy.In vitro and in vivo results show that the nanoassembly remarkably inhibits tumor growth as well as lungmetastasis,and extends tumorbearing mice survival.This work provides a promising paradigm of programmed delivering multi-site nanomedicine for cancer immunotherapy.展开更多
Perforation and fracturing are typically associated with the development of coalbed methane wells.As the cement sheath is prone to failure during this process,in this work,the effects of the casing pressure,elastic mo...Perforation and fracturing are typically associated with the development of coalbed methane wells.As the cement sheath is prone to failure during this process,in this work,the effects of the casing pressure,elastic modulus of the cement,elastic modulus of the formation,and casing eccentricity on the resulting stresses are analyzed in the frame of a finite element method.Subsequently,sensitivity response curves of the cement sheath stress are plotted by normalizing all factors.The results show that the maximum circumferential stress and Mises stress of the cement sheath increase with the casing internal pressure,elastic modulus of the cement and casing eccentricity.As the elastic modulus of the formation increases,the maximum circumferential stress of the cement sheath decreases,and its maximum Mises stress increases slightly.The cement sheath undergoes tensile failure during coalbed methane fracturing.The stress sensitivity of the cement sheath to the influential parameters is in the following order:casing internal pressure>elastic modulus of cement sheath>casing eccentricity>elastic modulus of formation.展开更多
BACKGROUND Heart failure(HF),an end-stage manifestation of various cardiac diseases,poses an enormous economic and health burden on society.Vericiguat may be an effective drug in the treatment of HF.AIM To explore by ...BACKGROUND Heart failure(HF),an end-stage manifestation of various cardiac diseases,poses an enormous economic and health burden on society.Vericiguat may be an effective drug in the treatment of HF.AIM To explore by meta-analysis the efficacy and safety of Vericiguat in treating chronic heart failure.METHODS Databases,including PubMed,EMBASE,Web of Science,and Cochrane Library,were searched to collect all published randomized controlled trials(RCTs)on Vericiguat treatment of chronic heart failure from the earliest electronic records to those published in March 2023.Two investigators independently screened the literature according to inclusion and exclusion criteria,evaluated the quality of the studies,and extracted valid data before conducting a meta-analysis using RevMan5.4.RESULTS Four RCTs with 5919 patients were included,and the meta-analysis showed that treatment with 10 mg Vericiguat reduced the incidence of the primary endpoint(a composite of cardiovascular mortality and first heart-failure-related hospital-ization)in patients with chronic heart failure compared to placebo[relative risk(RR)=0.91,95%confidence interval(CI):0.85–0.98,P=0.01],and reduced the incidence of heart-failure-related hospitalization(RR=0.92,95%CI:0.84–1.00,P=0.05).However,for the incidence of cardiovascular and all-cause death,there were no significant differences between the Vericiguat and placebo groups.In addition,the two groups did not show significant differences in blood pressure,heart rate,and Kansas Cardiomyopathy Questionnaire physical limitation score.In terms of safety,10 mg Vericiguat did not increase the risk of adverse effects in patients with chronic heart failure.Vericiguat may increase the risk of symp-tomatic hypotension(RR=1.17,95%CI:0.98–1.39,P=0.08)and syncope(RR=1.18,95%CI:0.90–1.55,P=0.24),but not significantly.CONCLUSION Vericiguat(10 mg)was more effective than placebo in treating patients with chronic heart failure and had a better safety profile.展开更多
The ionosphere is the ionized part of the upper atmosphere of the Earth,which plays an important role in atmospheric electricity and forms the inner edge of the magnetosphere.It influences radio propagation significan...The ionosphere is the ionized part of the upper atmosphere of the Earth,which plays an important role in atmospheric electricity and forms the inner edge of the magnetosphere.It influences radio propagation significantly,such as the Global Navigation Satellite System(GNSS).Meanwhile,the GNSS is also an essential technique for sensing the variation of ionosphere.During the years of 2019—2023,a large number of Chinese geodesy scientists devoted much efforts to the geodesy related ionosphere.Due to the very limited length,the achievements are carried out from the following six aspects,including:①The ionospheric correction models for BDS and BDSBAS;②Real-time global ionospheric monitoring and modeling;③The ionospheric 2D and 3D modeling based on GNSS and LEO satellites;④The ionospheric prediction based on artificial intelligence;⑤The monitoring and mitigation of ionospheric disturbances for GNSS users;⑥The ionospheric related data products and classical applications.展开更多
Under the control framework of algae bloom in eutrophic lakes and reservoirs based on biological manipulation, the temperature variable is introduced into ecological modeling to show that it is a necessary condition f...Under the control framework of algae bloom in eutrophic lakes and reservoirs based on biological manipulation, the temperature variable is introduced into ecological modeling to show that it is a necessary condition for the rapid occurrence of algal blooms, and an aquatic ecological model with temperature effect is proposed to describe dynamic relationship between algae and biological manipulation predator. The mathematical theory work mainly investigates the existence and stability of some equilibrium points and some critical conditions for the occurrence of transcritical bifurcation and Hopf bifurcation. The numerical simulation mainly shows the dynamic evolution process of bifurcation dynamics, which can not only verify the validity and feasibility of these theoretical works but also analyze the influence of some key parameters on dynamic behavior evolution. Furthermore, It is worth emphasizing that temperature plays an important role in the coexistence of algae and biological manipulation predators. Moreover, the coexistence mode of algae and biological manipulation predators is discovered by means of dynamic bifurcation evolution. Finally, it is hoped that these research results can provide some reference for the study of aquatic ecosystems.展开更多
为了改善心脏磁共振成像(Cardiac Magnetic Resonance,CMR)在实际应用中成像时间长且存在运动伪影等不足,将压缩感知理论(Compressed Sensing,CS)引入其中,充分利用K空间信息冗余的特性,实现由部分K空间数据重构心脏组织影像,在减少伪...为了改善心脏磁共振成像(Cardiac Magnetic Resonance,CMR)在实际应用中成像时间长且存在运动伪影等不足,将压缩感知理论(Compressed Sensing,CS)引入其中,充分利用K空间信息冗余的特性,实现由部分K空间数据重构心脏组织影像,在减少伪影、保证精度的同时加快成像速度。结合近3年的国内外文献,首先对CMR现状、常用序列和技术以及采样模式、压缩感知理论框架分别进行阐述;其次对CMR的最新成果及应用现状进行综述和概括;然后介绍压缩感知图像重构的相关定量评价指标,给出作者在CS-CMR图像重构方面的研究进展;最后总结当前研究中的不足,并展望未来的发展方向。展开更多
Combining the design of experiments(DOE)and three-dimensional finite element(3D-FE)method,a sequential multiobjectiveoptimization of larger diameter thin-walled(LDTW)Al-alloy tube bending under uncertainties was propo...Combining the design of experiments(DOE)and three-dimensional finite element(3D-FE)method,a sequential multiobjectiveoptimization of larger diameter thin-walled(LDTW)Al-alloy tube bending under uncertainties was proposed andimplemented based on the deterministic design results.Via the fractional factorial design,the significant noise factors are obtained,viz,variations of tube properties,fluctuations of tube geometries and friction.Using the virtual Taguchi’s DOE of inner and outerarrays,considering three major defects,the robust optimization of LDTW Al-alloy tube bending is achieved and validated.For thebending tools,the robust design of mandrel diameter was conducted under the fluctuations of tube properties,friction and tubegeometry.For the processing parameters,considering the variations of friction,material properties and manufacture deviation ofmandrel,the robust design of mandrel extension length and boosting ratio is realized.展开更多
Although intracranial hemorrhage in moyamoya disease can occur repeatedly,predicting the disease is difficult.Deep learning algorithms developed in recent years provide a new angle for identifying hidden risk factors,...Although intracranial hemorrhage in moyamoya disease can occur repeatedly,predicting the disease is difficult.Deep learning algorithms developed in recent years provide a new angle for identifying hidden risk factors,evaluating the weight of different factors,and quantitatively evaluating the risk of intracranial hemorrhage in moyamoya disease.To investigate whether convolutional neural network algorithms can be used to recognize moyamoya disease and predict hemorrhagic episodes,we retrospectively selected 460 adult unilateral hemispheres with moyamoya vasculopathy as positive samples for diagnosis modeling,including 418 hemispheres with moyamoya disease and 42 hemispheres with moyamoya syndromes.Another 500 hemispheres with normal vessel appearance were selected as negative samples.We used deep residual neural network(ResNet-152)algorithms to extract features from raw data obtained from digital subtraction angiography of the internal carotid artery,then trained and validated the model.The accuracy,sensitivity,and specificity of the model in identifying unilateral moyamoya vasculopathy were 97.64±0.87%,96.55±3.44%,and 98.29±0.98%,respectively.The area under the receiver operating characteristic curve was 0.990.We used a combined multi-view conventional neural network algorithm to integrate age,sex,and hemorrhagic factors with features of the digital subtraction angiography.The accuracy of the model in predicting unilateral hemorrhagic risk was 90.69±1.58%and the sensitivity and specificity were 94.12±2.75%and 89.86±3.64%,respectively.The deep learning algorithms we proposed were valuable and might assist in the automatic diagnosis of moyamoya disease and timely recognition of the risk for re-hemorrhage.This study was approved by the Institutional Review Board of Huashan Hospital,Fudan University,China(approved No.2014-278)on January 12,2015.展开更多
基金funded by the National Natural Science Foundation of China(grants 41571054 and 31622015)the National Basic Research Program of China(grant 2014CB954100)+1 种基金Sichuan University(Fundamental Research Funds for the Central Universities,SCU2021D006 and SCU2022D003Institutional Research Funds,2021SCUNL102).
文摘Biogeographical barriers to gene flow are central to plant phylogeography.In East Asia,plant distribution is greatly influenced by two phylogeographic breaks,the Mekong-Salween Divide and Tanaka-Kaiyong Line,however,few studies have investigated how these barriers affect the genetic diversity of species that are distributed across both.Here we used 14 microsatellite loci and four chloroplast DNA fragments to examine genetic diversity and distribution patterns of 49 populations of Populus rotundifolia,a species that spans both the Mekong-Salween Divide and the Tanaka-Kaiyong Line in southwestern China.Demographic and migration hypotheses were tested using coalescent-based approaches.Limited historical gene flow was observed between the western and eastern groups of P.rotundifolia,but substantial flow occurred across both the Mekong-Salween Divide and Tanaka-Kaiyong Line,manifesting in clear admixture and high genetic diversity in the central group.Wind-borne pollen and seeds may have facilitated the dispersal of P.rotundifolia following prevalent northwest winds in the spring.We also found that the Hengduan Mountains,where multiple genetic barriers were detected,acted on the whole as a barrier between the western and eastern groups of P.rotundifolia.Ecological niche modeling suggested that P.rotundifolia has undergone range expansion since the last glacial maximum,and demographic reconstruction indicated an earlier population expansion around 600 Ka.The phylogeographic pattern of P.rotundifolia reflects the interplay of biological traits,wind patterns,barriers,niche differentiation,and Quaternary climate history.This study emphasizes the need for multiple lines of evidence in understanding the Quaternary evolution of plants in topographically complex areas.
基金financially supported by 14^(th) Five-Year for Breeding Research Project of Sichuan Provincial Department of Science and Technology (2021YFYZ0008)。
文摘Rotavirus is one of the pathogenic causes that induce diarrhea in young animals, especially piglets, worldwide. However, nowadays, there is no specific drug available to treat the disease, and the related vaccines have no obvious efficiency in some countries. Via analyzing the pathogenesis of rotavirus, it inducing diarrhea is mainly due to disturb enteric nervous system, destroy gut mucosal integrity, induce intracellular electrolyte imbalance, and impair gut microbiota and immunity. Many studies have already proved that prebiotics and probiotics can mitigate the damage and diarrhea induced by rotavirus infection in hosts. Based on these, the current review summarizes and discusses the effects and mechanisms of prebiotics and probiotics on rotavirus-induced diarrhea in piglets. This information will highlight the basis for the swine production utilization of prebiotics and probiotics in the prevention or treatment of rotavirus infection in the future.
基金This study was financially supported by National Natural Science Foundation of China(grant No.U20A2080,31622015)the Institutional Research Fund from Sichuan University(2021SCUNL102)Fundamental Research Fund for the Central Universities of China(SCU 2021D006,SCU 2022D003).
文摘Endangered species generally have small populations with low genetic diversity and a high genetic load.Thuja sutchuenensis is an endangered conifer endemic to southwestern China.It was once considered extinct in the wild,but in 1999 was rediscovered.However,little is known about its genetic load.We collected 67 individuals from five wild,isolated T.sutchuenensis populations,and used 636,151 SNPs to analyze the level of genetic diversity and genetic load in T.sutchuenensis to delineate the conservation units of T.sutchuenensis,based on whole transcriptome sequencing data,as well as target capture sequencing data.We found that populations of T.sutchuenensis could be divided into three groups.These groups had low levels genetic diversity and were moderately genetically differentiated.Our findings also indicate that T.sutchuenensis suffered two severe bottlenecks around the Last Glaciation Period and Last Glacial Maximum.Among Thuja species,T.sutchuenensis presented the lowest genetic load and hence might have purged deleterious mutations efficiently through purifying selection.However,distribution of fitness effects analysis indicated a high extinction risk for T.sutchuenensis.Multiple lines of evidence identified three management units for T.sutchuenensis.Although T.sutchuenensis possesses a low genetic load,low genetic diversity,suboptimal fitness,and anthropogenic pressures all present an extinction risk for this rare conifer.This might also hold true for many endangered plant species in the mountains all over the world.
基金was supported by National Natural Science Foundation of China(81972893,82172719)Natural Science Foundation of Henan(212300410071)Training program for young key teachers in Henan Province(2020GGJS019).
文摘Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy,but fibrotic matrix severely blocks senescence inducers penetration and immune cells infiltration.Herein,we designed a cancer-associated fibroblasts(CAFs)triggered structure-transformable nano-assembly(HSD-P@V),which can directionally deliver valsartan(Val,CAFs regulator)and doxorubicin(DOX,senescence inducer)to the specific targets.In detail,DOX is conjugated with hyaluronic acid(HA)via diselenide bonds(Se-Se)to form HSD micelles,while CAFs-sensitive peptide is grafted onto the HSD to form a hydrophilic polymer,which is coated on Val nanocrystals(VNs)surface for improving the stability and achieving responsive release.Once arriving at tumor microenvironment and touching CAFs,HSD-P@V disintegrates into VNs and HSD micelles due to sensitive peptide detachment.VNs can degrade the extracellularmatrix,leading to the enhanced penetration of HSD.HSD targets tumor cells,releases DOX to induce senescence,and recruits effector immune cells.Furthermore,senescent cells are cleared by the recruited immune cells to finish the integrated anti-tumor therapy.In vitro and in vivo results show that the nanoassembly remarkably inhibits tumor growth as well as lungmetastasis,and extends tumorbearing mice survival.This work provides a promising paradigm of programmed delivering multi-site nanomedicine for cancer immunotherapy.
基金funded by the Provincial Geological Exploration Fund of Guizhou Province(208-9912-JBN-UTS0).
文摘Perforation and fracturing are typically associated with the development of coalbed methane wells.As the cement sheath is prone to failure during this process,in this work,the effects of the casing pressure,elastic modulus of the cement,elastic modulus of the formation,and casing eccentricity on the resulting stresses are analyzed in the frame of a finite element method.Subsequently,sensitivity response curves of the cement sheath stress are plotted by normalizing all factors.The results show that the maximum circumferential stress and Mises stress of the cement sheath increase with the casing internal pressure,elastic modulus of the cement and casing eccentricity.As the elastic modulus of the formation increases,the maximum circumferential stress of the cement sheath decreases,and its maximum Mises stress increases slightly.The cement sheath undergoes tensile failure during coalbed methane fracturing.The stress sensitivity of the cement sheath to the influential parameters is in the following order:casing internal pressure>elastic modulus of cement sheath>casing eccentricity>elastic modulus of formation.
基金Key Research and Development projects in Jiangxi Province,No.20223BBG71010National Natural Science Foundation of China,No.81960058.
文摘BACKGROUND Heart failure(HF),an end-stage manifestation of various cardiac diseases,poses an enormous economic and health burden on society.Vericiguat may be an effective drug in the treatment of HF.AIM To explore by meta-analysis the efficacy and safety of Vericiguat in treating chronic heart failure.METHODS Databases,including PubMed,EMBASE,Web of Science,and Cochrane Library,were searched to collect all published randomized controlled trials(RCTs)on Vericiguat treatment of chronic heart failure from the earliest electronic records to those published in March 2023.Two investigators independently screened the literature according to inclusion and exclusion criteria,evaluated the quality of the studies,and extracted valid data before conducting a meta-analysis using RevMan5.4.RESULTS Four RCTs with 5919 patients were included,and the meta-analysis showed that treatment with 10 mg Vericiguat reduced the incidence of the primary endpoint(a composite of cardiovascular mortality and first heart-failure-related hospital-ization)in patients with chronic heart failure compared to placebo[relative risk(RR)=0.91,95%confidence interval(CI):0.85–0.98,P=0.01],and reduced the incidence of heart-failure-related hospitalization(RR=0.92,95%CI:0.84–1.00,P=0.05).However,for the incidence of cardiovascular and all-cause death,there were no significant differences between the Vericiguat and placebo groups.In addition,the two groups did not show significant differences in blood pressure,heart rate,and Kansas Cardiomyopathy Questionnaire physical limitation score.In terms of safety,10 mg Vericiguat did not increase the risk of adverse effects in patients with chronic heart failure.Vericiguat may increase the risk of symp-tomatic hypotension(RR=1.17,95%CI:0.98–1.39,P=0.08)and syncope(RR=1.18,95%CI:0.90–1.55,P=0.24),but not significantly.CONCLUSION Vericiguat(10 mg)was more effective than placebo in treating patients with chronic heart failure and had a better safety profile.
基金National Key R&D Program of China(No.2021YFB3901301)National Natural Science Foundation of China(Nos.42074043,42122026,42174038)Youth Innovation Promotion Association of the Chinese Academy of Sciences(No.Y9E006033D)。
文摘The ionosphere is the ionized part of the upper atmosphere of the Earth,which plays an important role in atmospheric electricity and forms the inner edge of the magnetosphere.It influences radio propagation significantly,such as the Global Navigation Satellite System(GNSS).Meanwhile,the GNSS is also an essential technique for sensing the variation of ionosphere.During the years of 2019—2023,a large number of Chinese geodesy scientists devoted much efforts to the geodesy related ionosphere.Due to the very limited length,the achievements are carried out from the following six aspects,including:①The ionospheric correction models for BDS and BDSBAS;②Real-time global ionospheric monitoring and modeling;③The ionospheric 2D and 3D modeling based on GNSS and LEO satellites;④The ionospheric prediction based on artificial intelligence;⑤The monitoring and mitigation of ionospheric disturbances for GNSS users;⑥The ionospheric related data products and classical applications.
文摘Under the control framework of algae bloom in eutrophic lakes and reservoirs based on biological manipulation, the temperature variable is introduced into ecological modeling to show that it is a necessary condition for the rapid occurrence of algal blooms, and an aquatic ecological model with temperature effect is proposed to describe dynamic relationship between algae and biological manipulation predator. The mathematical theory work mainly investigates the existence and stability of some equilibrium points and some critical conditions for the occurrence of transcritical bifurcation and Hopf bifurcation. The numerical simulation mainly shows the dynamic evolution process of bifurcation dynamics, which can not only verify the validity and feasibility of these theoretical works but also analyze the influence of some key parameters on dynamic behavior evolution. Furthermore, It is worth emphasizing that temperature plays an important role in the coexistence of algae and biological manipulation predators. Moreover, the coexistence mode of algae and biological manipulation predators is discovered by means of dynamic bifurcation evolution. Finally, it is hoped that these research results can provide some reference for the study of aquatic ecosystems.
文摘为了改善心脏磁共振成像(Cardiac Magnetic Resonance,CMR)在实际应用中成像时间长且存在运动伪影等不足,将压缩感知理论(Compressed Sensing,CS)引入其中,充分利用K空间信息冗余的特性,实现由部分K空间数据重构心脏组织影像,在减少伪影、保证精度的同时加快成像速度。结合近3年的国内外文献,首先对CMR现状、常用序列和技术以及采样模式、压缩感知理论框架分别进行阐述;其次对CMR的最新成果及应用现状进行综述和概括;然后介绍压缩感知图像重构的相关定量评价指标,给出作者在CS-CMR图像重构方面的研究进展;最后总结当前研究中的不足,并展望未来的发展方向。
基金Project(51275415) supported by the National Natural Science Foundation of ChinaProject(51522509) supported by the National Science Fund for Excellent Young Scholars,China
文摘Combining the design of experiments(DOE)and three-dimensional finite element(3D-FE)method,a sequential multiobjectiveoptimization of larger diameter thin-walled(LDTW)Al-alloy tube bending under uncertainties was proposed andimplemented based on the deterministic design results.Via the fractional factorial design,the significant noise factors are obtained,viz,variations of tube properties,fluctuations of tube geometries and friction.Using the virtual Taguchi’s DOE of inner and outerarrays,considering three major defects,the robust optimization of LDTW Al-alloy tube bending is achieved and validated.For thebending tools,the robust design of mandrel diameter was conducted under the fluctuations of tube properties,friction and tubegeometry.For the processing parameters,considering the variations of friction,material properties and manufacture deviation ofmandrel,the robust design of mandrel extension length and boosting ratio is realized.
基金This study was supported by the National Natural Science Foundation of China,Nos.81801155(to YL),81771237(to YXG)the New Technology Projects of Shanghai Science and Technology Innovation Action Plan,China,No.18511102800(to YXG)+1 种基金the Shanghai Municipal Science and Technology Major Project and ZJLab,China,No.2018SHZDZX01(to YM)the Shanghai Health and Family Planning Commission,China,No.2017BR022(to YXG).
文摘Although intracranial hemorrhage in moyamoya disease can occur repeatedly,predicting the disease is difficult.Deep learning algorithms developed in recent years provide a new angle for identifying hidden risk factors,evaluating the weight of different factors,and quantitatively evaluating the risk of intracranial hemorrhage in moyamoya disease.To investigate whether convolutional neural network algorithms can be used to recognize moyamoya disease and predict hemorrhagic episodes,we retrospectively selected 460 adult unilateral hemispheres with moyamoya vasculopathy as positive samples for diagnosis modeling,including 418 hemispheres with moyamoya disease and 42 hemispheres with moyamoya syndromes.Another 500 hemispheres with normal vessel appearance were selected as negative samples.We used deep residual neural network(ResNet-152)algorithms to extract features from raw data obtained from digital subtraction angiography of the internal carotid artery,then trained and validated the model.The accuracy,sensitivity,and specificity of the model in identifying unilateral moyamoya vasculopathy were 97.64±0.87%,96.55±3.44%,and 98.29±0.98%,respectively.The area under the receiver operating characteristic curve was 0.990.We used a combined multi-view conventional neural network algorithm to integrate age,sex,and hemorrhagic factors with features of the digital subtraction angiography.The accuracy of the model in predicting unilateral hemorrhagic risk was 90.69±1.58%and the sensitivity and specificity were 94.12±2.75%and 89.86±3.64%,respectively.The deep learning algorithms we proposed were valuable and might assist in the automatic diagnosis of moyamoya disease and timely recognition of the risk for re-hemorrhage.This study was approved by the Institutional Review Board of Huashan Hospital,Fudan University,China(approved No.2014-278)on January 12,2015.
