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骨髓增生异常综合征骨髓免疫微环境的变化
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作者 洪明华 孙洁 《临床医学研究与实践》 2021年第14期195-198,共4页
肿瘤微环境已被证实与疾病发生发展、治疗效果及生存预后相关。骨髓增生异常综合征(MDS)具有独特的骨髓(BM)免疫微环境,同时异常的BM微环境有助于肿瘤克隆的增殖,促进MDS的发生、发展。对BM微环境,尤其在免疫微环境方面的研究,有助于探... 肿瘤微环境已被证实与疾病发生发展、治疗效果及生存预后相关。骨髓增生异常综合征(MDS)具有独特的骨髓(BM)免疫微环境,同时异常的BM微环境有助于肿瘤克隆的增殖,促进MDS的发生、发展。对BM微环境,尤其在免疫微环境方面的研究,有助于探索MDS的病理生理过程,为合适的免疫治疗提供理论基础。本文就MDS中骨髓间充质干细胞对BM免疫微环境的影响及BM免疫微环境的变化作一综述。 展开更多
关键词 骨髓增生异常综合征 骨髓免疫微环境 骨髓间充质干细胞
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骨髓增生异常肿瘤的骨髓微环境促进疾病发生发展的机制
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作者 洪明华 常春康 《中华血液学杂志》 CAS CSCD 北大核心 2023年第4期350-352,共3页
骨髓增生异常肿瘤(myelodysplastic neoplasms,MDS)是一种以造血干细胞克隆增殖、骨髓增生异常、无效造血、外周血细胞减少,高风险发展为急性髓系白血病(AML)为特征的恶性疾病[1]。基因和表观遗传学变化及异常的骨髓微环境以多步骤和克... 骨髓增生异常肿瘤(myelodysplastic neoplasms,MDS)是一种以造血干细胞克隆增殖、骨髓增生异常、无效造血、外周血细胞减少,高风险发展为急性髓系白血病(AML)为特征的恶性疾病[1]。基因和表观遗传学变化及异常的骨髓微环境以多步骤和克隆进化的方式促成MDS或AML的转化[2]。但是,携带MDS常见基因突变的造血干祖细胞(hematopoietic stem and progenitor cells,HSPC)无独立的细胞自主增殖能力,并不能单独为恶性克隆提供增殖优势[3]。因此骨髓微环境的变化及其与HSPC的双向交流被认为在启动MDS的发生和支持肿瘤克隆的发展中起到关键作用。 展开更多
关键词 骨髓微环境 骨髓增生异常 克隆增殖 NEOPLASMS 造血干细胞 无效造血 表观遗传学 基因突变
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Auroral substorm response to solar wind pressure shock 被引量:5
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作者 hong minghua WANG Xianmin +1 位作者 D.Chua G.Parks 《Chinese Science Bulletin》 SCIE EI CAS 2001年第18期1547-1551,1587,共6页
Two cases of auroral substorms have been studied with the Polar UVI data, which were associated with solar wind pressure shock arriving at the Earth. The global aurora activities started about 1-2 min after pressure s... Two cases of auroral substorms have been studied with the Polar UVI data, which were associated with solar wind pressure shock arriving at the Earth. The global aurora activities started about 1-2 min after pressure shocks arrived at dayside magnetopause, then nightside auroras intensified rapidly 3-4 min later, with auroral sub-storm onset. The observations in synchronous orbit indicated that the compressing effects on magnetosphere were observed in their corresponding sites about 2 min after the pressure shocks impulse magnetopause. We propose that the auroral intensification and substorm onset possibly result from hydromagnetic wave produced by the pressure shock. The fast-mode wave propagates across the magnetotail lobes with higher local Alfven velocity, magnetotail was compressed rapidly and strong lobe field and cross-tail current were built in about 1-2 min, and furthermore the substorm was triggered due to an instability in current sheet. 展开更多
关键词 auroral SUBSTORM SOLAR WIND pressure shock hydro-magnetic wave.
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Nightside field-aligned current during the April 6,2000 superstorm 被引量:3
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作者 WANG Yuan hong minghua +5 位作者 CHEN GengXiong XU WenYao DU AiMin ZHAO XuDong LIU XiaoCan LUO Hao 《Chinese Science Bulletin》 SCIE EI CAS 2010年第20期2175-2181,共7页
Using the east-west geomagnetic disturbance fields observed from stations at mid-latitudes,we investigate the characteristics of field-aligned currents on the nightside during the April 6,2000 superstorm.The results i... Using the east-west geomagnetic disturbance fields observed from stations at mid-latitudes,we investigate the characteristics of field-aligned currents on the nightside during the April 6,2000 superstorm.The results indicate that there is an eastward disturbance on the nightside of Northern Hemisphere during the main phase of magnetic storm,while the interplanetary magnetic field(IMF)is continued southward.The positive disturbances in the postmidnight are larger than that in the premidnight.This suggests that upward field-aligned currents develop on the nightside,when the IMF is directed southward.The peak of upward fieldaligned currents is located in postmidnight,and it will be more obvious at substorm expansion.We get the conclusion that both partial ring current and region-2 field-aligned current shift to dusk sector.The upward region-2 current is decreased at substorm onset,and intensified after it.We also investigate the relationship between the upward field-aligned currents on the nightside and the auroral electrojets at high latitudes.It shows a good correspondence between region-2 current and the westward electrojet in the postmidnight.We suppose that they are both associated with the convection electric field. 展开更多
关键词 场向电流 国际货币基金组织 中纬度地区 高纬度地区 星际磁场 电流转移 对应关系 对流电场
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