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EBV编码的BART microRNA在鼻咽癌中的表达及对患者免疫功能的影响 被引量:7
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作者 洪逸光 陈静 《免疫学杂志》 CAS CSCD 北大核心 2020年第5期426-431,共6页
目的探究EB病毒(EBV)编码的BART微小RNA(miRNA)在鼻咽癌中的表达及对患者免疫功能的影响。方法选择我院2015年6月至2018年3月耳鼻咽喉头颈外科收治的鼻咽癌患者57例作为研究组,另选择同期来院治疗的慢性鼻窦炎鼻息肉患者42例作为对照组... 目的探究EB病毒(EBV)编码的BART微小RNA(miRNA)在鼻咽癌中的表达及对患者免疫功能的影响。方法选择我院2015年6月至2018年3月耳鼻咽喉头颈外科收治的鼻咽癌患者57例作为研究组,另选择同期来院治疗的慢性鼻窦炎鼻息肉患者42例作为对照组。分别采用RT-PCR法与Western blot法检测鼻咽癌组织与鼻息肉组织中EBV BART miRNA表达水平与Fas、CD44s与CD44变异体6(CD44v6)蛋白表达水平;采用酶联免疫吸附法与细胞分析仪分别检测研究组放疗前后及对照组血清中EB病毒衣壳抗原免疫球蛋白-A(VCA-IgA)、早期抗原免疫球蛋白-A(EA-IgA)、CD8^+、CD4^+T细胞水平;分析鼻咽癌组织中EBV BART miRNA表达水平与Fas、CD44s与CD44v6蛋白表达水平的相关性。结果鼻咽癌组织中EBV BART miRNA表达水平较鼻息肉组织明显提高(P<0.05);研究组患者VCA-IgA与EA-IgA、CD8^+T细胞、CD8^+/CD4^+水平较对照组受试者明显提高,CD4^+T细胞水平较对照组受试者明显降低(P<0.05);鼻咽癌患者放疗前VCA-IgA与EA-IgA、CD8^+T细胞、CD8^+/CD4^+水平均明显大于放疗后,CD4^+T细胞水平明显小于化疗后(P<0.05);鼻咽癌组织中Fas蛋白相对表达水平明显低于鼻息肉组织(P<0.05);且鼻咽癌组织中CD44s与CD44v6蛋白相对表达水平明显高于鼻息肉组织(P<0.05);鼻咽癌组织中EBV BART miRNA表达水平与Fas蛋白相对表达水平、CD4^+T细胞水平呈明显负相关(P<0.05);鼻咽癌组织中EBV BART miRNA表达水平与CD44s和CD44v蛋白相对表达水平、CD8^+T细胞水平呈明显正相关(P<0.05)。结论 EBV BART miRNA在鼻咽癌组织中呈高表达;EBV相关抗体在鼻咽癌患者血清中呈高表达;EBV BART miRNA可能通过影响免疫来介导鼻咽癌的发生发展。 展开更多
关键词 鼻咽癌 MIRNA 免疫 侵袭 细胞凋亡
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Equalizer Zero-Determinant Strategy in Discounted Repeated Stackelberg Asymmetric Game
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作者 CHENG Zhaoyang CHEN Guanpu hong yiguang 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2024年第1期184-203,共20页
This paper focuses on the performance of equalizer zero-determinant(ZD)strategies in discounted repeated Stackelberg asymmetric games.In the leader-follower adversarial scenario,the strong Stackelberg equilibrium(SSE)... This paper focuses on the performance of equalizer zero-determinant(ZD)strategies in discounted repeated Stackelberg asymmetric games.In the leader-follower adversarial scenario,the strong Stackelberg equilibrium(SSE)deriving from the opponents’best response(BR),is technically the optimal strategy for the leader.However,computing an SSE strategy may be difficult since it needs to solve a mixed-integer program and has exponential complexity in the number of states.To this end,the authors propose an equalizer ZD strategy,which can unilaterally restrict the opponent’s expected utility.The authors first study the existence of an equalizer ZD strategy with one-to-one situations,and analyze an upper bound of its performance with the baseline SSE strategy.Then the authors turn to multi-player models,where there exists one player adopting an equalizer ZD strategy.The authors give bounds of the weighted sum of opponents’s utilities,and compare it with the SSE strategy.Finally,the authors give simulations on unmanned aerial vehicles(UAVs)and the moving target defense(MTD)to verify the effectiveness of the proposed approach. 展开更多
关键词 Discounted repeated Stackelberg asymmetric game equalizer zero-determinant strategy strong Stackelberg equilibrium strategy
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鼻腔手术填塞后合理使用抗生素的研究 被引量:5
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作者 陈静 黄立高 +6 位作者 胡秀娟 张杰 洪逸光 康伟 刘栖如 王春敏 赵敏 《临床耳鼻咽喉头颈外科杂志》 CAS 北大核心 2018年第13期998-1001,共4页
目的:研究鼻窦炎患者及非鼻窦炎患者鼻腔手术后是否应使用抗生素、如何使用抗生素,从而进一步指导鼻腔术后规范使用抗生素。方法:前瞻性分层随机对照研究,将手术患者分为鼻窦炎和非鼻窦炎两层,鼻窦炎组患者依据抗生素使用分为非抗生素... 目的:研究鼻窦炎患者及非鼻窦炎患者鼻腔手术后是否应使用抗生素、如何使用抗生素,从而进一步指导鼻腔术后规范使用抗生素。方法:前瞻性分层随机对照研究,将手术患者分为鼻窦炎和非鼻窦炎两层,鼻窦炎组患者依据抗生素使用分为非抗生素使用组(A组)、标准抗生素使用组(B组)及延长抗生素使用组(C组);非鼻窦炎手术组患者随机分为非抗生素使用组(D组)、标准抗生素使用组(E组)及延长抗生素使用组(F组)。观察每组患者的术后感染率并分层比较。结果:鼻窦炎组内A、B、C组的感染率分别是3.53%、2.67%、0.00%,组间差异无统计学意义。非鼻窦炎组内D、E、F组的感染率分别为1.22%、0.00%、1.39%,组间差异无统计学意义。结论:鼻窦炎及非鼻窦炎患者鼻腔术后不使用或标准使用及延长使用抗生素对术后感染率无影响,推荐不使用抗生素,酌情按规范使用48h以内,不推荐延长使用。 展开更多
关键词 鼻腔手术 感染 抗生素 合理使用
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SOLVABILITY AND CONTROL DESIGN FOR SYNCHRONIZATION OF BOOLEAN NETWORKS 被引量:8
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作者 XU Xiangru hong yiguang 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2013年第6期871-885,共15页
This paper addresses the synchronization problem of Boolean networks.Based on the matrix expression of logic,solvability conditions and design procedures of the synchronization of Boolean networks with outputs are giv... This paper addresses the synchronization problem of Boolean networks.Based on the matrix expression of logic,solvability conditions and design procedures of the synchronization of Boolean networks with outputs are given for both open-loop and feedback control.Necessary and sufficient conditions on open-loop control are proposed first with a constructive design procedure.Then sufficient condition for the feedback control case is obtained,and corresponding design procedure is proposed with the help of algorithms to solve logic matrix equations.Numerical examples are also provided to illustrate the proposed control design. 展开更多
关键词 可解性条件 布尔网络 控制设计 行同步 充分必要条件 反馈控制 设计过程 矩阵表达式
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Distributed Algorithm for Robust Resource Allocation with Polyhedral Uncertain Allocation Parameters 被引量:3
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作者 ZENG Xianlin YI Peng hong yiguang 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2018年第1期103-119,共17页
这份报纸在多面的不明确的分配参数下面与 nonsmooth 目的功能学习一个分布式的柔韧的资源分配问题。处于考虑分布式的柔韧的资源分配问题,(nonsmooth ) 客观功能是在一个多代理人网络分到代理人的本地凸的客观功能的和。每个代理人有... 这份报纸在多面的不明确的分配参数下面与 nonsmooth 目的功能学习一个分布式的柔韧的资源分配问题。处于考虑分布式的柔韧的资源分配问题,(nonsmooth ) 客观功能是在一个多代理人网络分到代理人的本地凸的客观功能的和。每个代理人有一个私人可行集合并且决定一个本地变量,和所有本地变量被结合全球仿射的不平等限制,它服从于多面的不明确的参数。与凸的优化的两重性理论,作者导出柔韧的资源分配问题的一个柔韧的对应物。基于柔韧的对应物,作者建议一个新奇分布式的连续时间的算法,每个代理人仅仅在知道它的本地客观功能,本地无常参数,本地限制集合,和它的邻居信息。用微分包括的稳定性理论,作者证明算法能在一些温和条件下面发现最佳的答案。最后,作者给一个例子说明建议算法的功效。 展开更多
关键词 资源分配问题 分布式 柔韧 算法 稳定性理论 代理人 连续时间 温和条件
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Distributed Consensus-Based K-Means Algorithm in Switching Multi-Agent Networks 被引量:3
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作者 LIN Peng WANG Yinghui +1 位作者 QI hongsheng hong yiguang 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2018年第5期1128-1145,共18页
关键词 网络拓扑学 分布式 代理人 算法 工具 连接条件 聚类 作者
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Distributed High-Gain Attitude Synchronization Using Rotation Vectors
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作者 SONG Wenjun THUNBERG Johan +1 位作者 HU Xiaoming hong yiguang 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2015年第2期289-304,共16页
This paper addresses attitude synchronization problems for systems of multiple rigid-body agents with directed interconnection topologies.Two scenarios which differ in available information are considered.In the first... This paper addresses attitude synchronization problems for systems of multiple rigid-body agents with directed interconnection topologies.Two scenarios which differ in available information are considered.In the first scenario the agents can obtain their rotations and angular velocities relative to an inertial reference frame and transmit these information to their neighbors,while in the second scenario the agents can only obtain their own angular velocities and measure the relative rotations and relative angular velocities of their neighbors.By using rotation vectors and the high gain control,the authors provide torque control laws asymptotically synchronizing the rotations of the system almost globally for the first scenario and with initial rotations of the agents contained in a convex ball of SO(3)for the second scenario.An illustrative example is provided to show the synchronization results for both scenarios. 展开更多
关键词 同步系统 旋转向量 高增益 分布式 姿态 角速度 互连系统 拓扑结构
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STABILIZATION OF NONLINEAR SYSTEMS WITH HOMOGENEOUS STABILITY
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作者 hong yiguang CHENG Daizhan QIN Huashu(Institute Of Systems Science, Academia Sinica, Beijing 100080, China) 《Systems Science and Mathematical Sciences》 SCIE EI CSCD 1999年第S1期104-109,共6页
In this paper, we use center manifold theory to give a new result aboutthe stabilization of nonlinear systems. First an illustrative example is given to show ourmotivation. Then the main result by means of center mani... In this paper, we use center manifold theory to give a new result aboutthe stabilization of nonlinear systems. First an illustrative example is given to show ourmotivation. Then the main result by means of center manifold and homogeneous stabilityis proposed, and its application to a generalized form without the usual relative degreebecause of singularity is given. 展开更多
关键词 STABILIZATION of nonlinear systems CENTER MANIFOLD HOMOGENEOUS stability.
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Modeling and Control of Telerobotic Systemswith Time-delays
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作者 hong yiguang WANG Long ZHENG Chaozhou(Institute of Systems Science, Academia Sinica,Beijing 100080 ) (Department of Mechanics and Engineering Science, Petw Univeforty, BejjiDg 100871) 《Systems Science and Systems Engineering》 CSCD 1999年第2期252-257,共6页
Telerobotic systems become more and more important due to emerging hi-technologyand practical requirement in modern society. This paper studies+ and integrates the modeling, taskscheduling, action planning and control... Telerobotic systems become more and more important due to emerging hi-technologyand practical requirement in modern society. This paper studies+ and integrates the modeling, taskscheduling, action planning and control of telerobot systems. Such hybrid syStems often involve coalmunication, command and control, and are so complex that no efficient and simple method could befound to analyze and design systems. To increase the efficiency, reliability and safety oftelrobot syStems,the consideration of task scheduling and action planning in a unified framework could be an importantstep. The discrete-event dynamics is modeled as a linear state-spare equation in Mad-Algebra sense.Performance evaluation can be carried out efficiently. Then analysis about time-delay continuous-timedynamics is given for the scheduling and control, which shows that, to simplify the design procedure,it is necessary to present a good delay scheduling, for example, by changing multi-time-delays to singleones in advance. Robustness conditions are derived using graph theory for dipcrete-event dynamics andmatrix analysis for continuous-time dynamics. 展开更多
关键词 TELEROBOT discrete-event modeling time-delay control robustness analysis task Wheduling
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Robust H_∞ Control of Robot Manipulator
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作者 hong yiguang SHI Aifen QIN Huashu 《Systems Science and Systems Engineering》 CSCD 1998年第2期56-62,共7页
1IntroductionAsweknow,becauseofenvironmentalconditionsandspecialdesigndemands,ro-bustnessforrobotcontrolbeco... 1IntroductionAsweknow,becauseofenvironmentalconditionsandspecialdesigndemands,ro-bustnessforrobotcontrolbecomemoreandmoreimpo... 展开更多
关键词 Robust H∞ control Robot manipulator Radial solution.
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