Learning Discriminatory Information for Object Detection on Urine Sediment Image

In clinical practice,the microscopic examination of urine sediment is considered an important in vitro examination with many broad applications.Measuring the amount of each type of urine sediment allows for screening,diagnosis and evaluation of kidney and urinary tract disease,providing insight into the specific type and severity.However,manual urine sediment examination is labor-intensive,time-consuming,and subjective.Traditional machine learning based object detection methods require hand-crafted features for localization and classification,which have poor generalization capabilities and are difficult to quickly and accurately detect the number of urine sediments.Deep learning based object detection methods have the potential to address the challenges mentioned above,but these methods require access to large urine sediment image datasets.Unfortunately,only a limited number of publicly available urine sediment datasets are currently available.To alleviate the lack of urine sediment datasets in medical image analysis,we propose a new dataset named UriSed2K,which contains 2465 high-quality images annotated with expert guidance.Two main challenges are associated with our dataset:a large number of small objects and the occlusion between these small objects.Our manuscript focuses on applying deep learning object detection methods to the urine sediment dataset and addressing the challenges presented by this dataset.Specifically,our goal is to improve the accuracy and efficiency of the detection algorithm and,in doing so,provide medical professionals with an automatic detector that saves time and effort.We propose an improved lightweight one-stage object detection algorithm called Discriminatory-YOLO.The proposed algorithm comprises a local context attention module and a global background suppression module,which aid the detector in distinguishing urine sediment features in the image.The local context attention module captures context information beyond the object region,while the global background suppression module emphasizes objects in uninformative backgrounds.We comprehensively evaluate our method on the UriSed2K dataset,which includes seven categories of urine sediments,such as erythrocytes(red blood cells),leukocytes(white blood cells),epithelial cells,crystals,mycetes,broken erythrocytes,and broken leukocytes,achieving the best average precision(AP)of 95.3%while taking only 10 ms per image.The source code and dataset are available at https://github.com/binghuiwu98/discriminatoryyolov5.

新工科背景下应用化学综合实验课程思政育人实践

针对新工科理念和课程思政的要求,避免专业教育和思政教育“两张皮”的问题,从教材、课程教学和平台建设等方面介绍了新工科理念和课程思政在应用化学综合实验中的有机融合实践。在前期课程教学基础和初步实践基础上,提出了建设配套教材、发挥线上线下教学、搭建校内科研与工程实践平台、拓展校外实践基地等具体的改革路径,将课程思政全方位融入教学活动中,构建了应用化学综合实验课程思政育人新体系,助力新工科背景下新兴应用型人才培养。该实践可为其他实验课程开展新工科背景下课程思政改革提供参考。

Rational Design of High-Performance PEO/Ceramic Composite Solid Electrolytes for Lithium Metal Batteries

Composite solid electrolytes(CSEs)with poly(ethylene oxide)(PEO)have become fairly prevalent for fabricating high-performance solid-state lithium metal batteries due to their high Li~+solvating capability,flexible processability and low cost.However,unsatisfactory room-temperature ionic conductivity,weak interfacial compatibility and uncontrollable Li dendrite growth seriously hinder their progress.Enormous efforts have been devoted to combining PEO with ceramics either as fillers or major matrix with the rational design of two-phase architecture,spatial distribution and content,which is anticipated to hold the key to increasing ionic conductivity and resolving interfacial compatibility within CSEs and between CSEs/electrodes.Unfortunately,a comprehensive review exclusively discussing the design,preparation and application of PEO/ceramic-based CSEs is largely lacking,in spite of tremendous reviews dealing with a broad spectrum of polymers and ceramics.Consequently,this review targets recent advances in PEO/ceramicbased CSEs,starting with a brief introduction,followed by their ionic conduction mechanism,preparation methods,and then an emphasis on resolving ionic conductivity and interfacial compatibility.Afterward,their applications in solid-state lithium metal batteries with transition metal oxides and sulfur cathodes are summarized.Finally,a summary and outlook on existing challenges and future research directions are proposed.

Dielectric polarization in MgFe_(2)O_(4) coating and bulk doping to enhance high-voltage cycling stability of Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2) cathode material

Charging P2-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)to 4.5 V for higher capacity is enticing.However,it leads to severe capacity fading,ascribing to the lattice oxygen evolution and the P2-O2 phase transformation.Here,the Mg Fe_(2)O_(4) coating and Mg,Fe co-doping were constructed simultaneously by Mg,Fe surface treatment to suppress lattice oxygen evolution and P2-O2 phase transformation of P2-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)at deep charging.Through ex-situ X-ray diffraction(XRD)tests,we found that the Mg,Fe bulk co-doping could reduce the repulsion between transition metals and Na+/vacancies ordering,thus inhibiting the P2-O2 phase transition and significantly reducing the irreversible volume change of the material.Meanwhile,the internal electric field formed by the dielectric polarization of Mg Fe_(2)O_(4) effectively inhibits the outward migration of oxidized O^(a-)(a<2),thereby suppressing the lattice oxygen evolution at deep charging,confirmed by in situ Raman and ex situ XPS techniques.P2-Na NM@MF-3 shows enhanced high-voltage cycling performance with capacity retentions of 84.8% and 81.3%at 0.1 and 1 C after cycles.This work sheds light on regulating the surface chemistry for Na-layered oxide materials to enhance the high-voltage performance of Na-ion batteries.

Pressure-induced growth of coralloid-like FeF_(2) nanocrystals to enable high-performance conversion cathode

Fluoride ferrous(FeF_(2))is viewed as a promising conversion cathode material for next-generation lithiumion batteries(LIBs)due to its high theoretical specific capacity and low cost.Unfortunately,issues such as poor intrinsic conductivity,iron dissolution,and phase separation hinder the application of FeF_(2)in highenergy cathodes.Here,a pressure-induced morphology control method is designed to prepare coralloidlike FeF_(2)nanocrystals with nitrogen-rich carbon coating(c-FeF_(2)@NC).The coralloid-like interconnected crystal structure of c-FeF_(2)@NC contributes to reducing interfacial resistance and enhancing the topotactic transformation during the conversion reaction,and the nitrogen-rich carbon(NC)coating can enhance interfacial stability and kinetic performance.When used as a conversion cathode for LIBs,c-FeF_(2)@NC exhibits a high initial reversible capacity of 503.57 mA h g^(-1)and excellent cycling stability of497.61 m A h g^(-1)with a low capacity decay of 1.19%over 50 cycles at 0.1 A/g.Even at 1 A/g,a stable capacity of 263.78 mA h g^(-1)can still be retained after 200 cycles.The capability of c-FeF_(2)@NC as a conversion cathode for sodium-ion batteries(SIBs)was also evaluated to expand its field of application.Furthermore,two kinds of full batteries have been assembled by employing c-FeF_(2)@NC as cathodes and quantitative limited-Li(LLi)and pre-lithiated reduced graphene oxide(PGO)as anodes,respectively,to envisage the feasibility of practical applications of conversion materials.

创新社会实践课程体系,助力专业人才培养——以广西师范大学应用化学专业为例

以提升学生的专业素养为目标,从教学团队、课程内容、教学资源、教学模式、考核方式等方面对应用化学专业社会实践课程进行改革,构建了凸显专业性和创新性的逐级递进式社会实践课程内容体系,实施了线上线下相结合的多元化教学策略,实现了专业教育、社会服务和课程思政的高度融合,提高了地方院校应用化学专业人才的培养质量。

氧化铝包覆量对锰酸锂正极材料电化学性能的影响

针对锰酸锂正极材料存在循环性能差的问题,以九水硝酸铝(Al(NO3)3·9H2O)和尖晶石锰酸锂(LiMn2O4)为原料,采用溶胶–凝胶法制备氧化铝包覆锰酸锂正极材料,研究氧化铝包覆量(氧化铝与锰酸锂的质量比)对锰酸锂正极材料的结构及其电化学性能的影响。采用XRD和SEM等手段研究合成材料的晶体结构和微观形貌;通过循环充放电测试和循环伏安法等方法研究其电化学性能。XRD和SEM结果表明:氧化铝的包覆并没有改变锰酸锂的晶体结构,只是包覆在锰酸锂的表面。电化学性能测试结果表明,当氧化铝包覆量为1.0%时,材料具有较好的循环性能,1 C条件下,循环200周容量保持率为96.96%,锰酸锂为52.78%。

Porous nitrogen-enriched hollow carbon nanofibers as freestanding electrode for enhanced lithium storage

Onedimensional porous carbons bearing high surface areas and sufficient heteroatom doped functionalities are essential for advanced electrochemical energy storage devices,especially for developing freestanding film electrodes.Here we develop a porous,nitrogenenriched,freestanding hollow carbon nanofiber(PNFHCF)electrode material via filtration of polypyrrole(PPy)hollow nanofibers formed by in situ selfdegraded templateassisted strategy,followed by NH3assisted carbonization.The PNFHCF retains the freestanding film morphology that is composed of threedimensional networks from the entanglement of 1D nanofiber and delivers 3.7fold increase in specific surface area(592 m^(2)g^(-1))compared to the carbon without NH_(3)treatment(FHCF).In spite of the enhanced specific surface area,PNFHCF still exhibits comparable high content of surface N functionalities(8.8%,atom fraction)to FHCF.Such developed hierarchical porous structure without sacrificing N doping functionalities together enables the achievement of high capacity,highrate property and good cycling stability when applied as selfsupporting anode in lithiumion batteries,superior to those of FHCF without NH3 treatment.

Hierarchically porous, ultrathin N–doped carbon nanosheets embedded with highly dispersed cobalt nanoparticles as efficient sulfur host for stable lithium–sulfur batteries

The sluggish redox kinetics and shuttle effect of soluble polysulfides intermediate primarily restrict the electrochemical performance of lithium–sulfur(Li–S) batteries. To address this issue, rational design of high–efficiency sulfur host is increasingly demanded to accelerate the polysulfides conversion during charge/discharge process. Herein, we propose a macro–mesoporous sulfur host(Co@NC), which comprises highly dispersed cobalt nanoparticles embedding in N–doped ultrathin carbon nanosheets. Co@NC is simply synthesized via a carbon nitride–derived pyrolysis approach. Owing to the highly conductive graphene–like matrix and well defined porous structure, the designed multifunctional Co@NC host enables rapid electron/ion transport, electrolyte penetration and effective sulfur trapping. More significantly,N heteroatoms and homogeneous Co nanocatalysts in the graphitic carbon nanosheets could serve as chemisorption sites as well as electrocatalytic centers for sulfur species. These Co–N active sites can synergistically facilitate the redox conversion kinetics and mitigate the shuttling of polysulfides, thus leading to improved electrochemical cycling performance of Li–S batteries. As a consequence, the S/Co@NC cathode demonstrates high initial specific capacity(1505 mA h g-1 at 0.1 C) and excellent cycling stability at 1 C over 300 cycles, giving rise to a capacity retention of 91.7% and an average capacity decline of 0.03%cycle-1.

Ala-Gln improves varicocele-induced testicular injury by increasing HSP70 and antioxidant activity in male rats

This worked aimed to test the hypothesis that L-alanyl-L-glutamine(Ala-Gln)improves the varicocele-induced testicular injury,which causes male infertility.For this purpose,fifty adult male Wistar rats received the varicocele(VC)surgery at the left renal vein.Biomarkers were determined 2,4,and 8 weeks after VC(n=10/each detection).Four weeks after VC,rats received Ala-Gln(1.125 g/kg)treatment with and or saline for 1 week(n=10/each group).Rats in the sham group were also detected for biomarkers at 2,4,and 8 weeks(n=10/each detection).VC caused testicular injury detected by hematoxylin–eosin(H&E)staining,immunohistochemistry,and TUNEL assay.HSP70 mRNA was detected quantitative RT-PCR,SOD,and CAT by nitroblue tetrazolium(NBT)method and 8-OHDG by ELISA.The results showed that varicocele induced injury in the testes.The weight of the left testes was lower than that of the right testes in VC-bearing rats(p<0.01).The relative numbers of sustentacular and spermatogenic cells were decreased after VC(p<0.01).In sham-4 wk,VC-4wk,VC-5wk and Ala-Gln groups,the apoptosis index was 5.10±1.14,13.22±3.63,33.62±3.56 and 22.33±2.61,relative level of HSP70 mRNA 1.00±0.12,0.53±0.05,0.51±0.04 and 1.62±0.15 fold,SOD 16.4±0.23,13.4±0.17,10.01±1.06 and 19.53±2.26 U/mg protein,CAT 2.16±0.31,1.07±0.28,and 1.31±0.26 and 3.46±0.71 U/mg,8-OHDG 5.23±0.67,6.81±0.78,7.16±1.22 and 4.14±0.73 pg/μg DNA,respectively(p<0.01).Our results suggest that Ala-Gln prevented the VC-induced testicular injury.We have firstly reported that Ala-Gln protects against varicocele-induced testicular injuries by up-regulation of HSP70 and antioxidants,SOD and CAT,and down-regulation of oxidant 8-OHDG,resulting in reducing apoptosis in the testis.

Reduced Graphene Oxide-Wrapped FeS_2 Composite as Anode for High-Performance Sodium-Ion Batteries

Iron disulfide is considered to be a potential anode material for sodium-ion batteries due to its high theoretical capacity. However, its applications are seriously limited by the weak conductivity and large volume change, which results in low reversible capacity and poor cycling stability.Herein, reduced graphene oxide-wrapped FeS_2(FeS_2/rGO)composite was fabricated to achieve excellent electrochemical performance via a facile two-step method. The introduction of rGO effectively improved the conductivity,BET surface area, and structural stability of the FeS_2 active material, thus endowing it with high specific capacity, good rate capability, as well as excellent cycling stability. Electrochemical measurements show that the FeS_2/rGO composite had a high initial discharge capacity of 1263.2 mAh gg^(-1) at 100 mA gg^(-1) and a high discharge capacity of 344 mAh gg^(-1) at 10 A gg^(-1), demonstrating superior rate performance. After 100 cycles at 100 mA gg^(-1),the discharge capacity remained at 609.5 mAh g^(-1), indicating the excellent cycling stability of the FeS_2/rGO electrode.

Autofocus technique for ISAR imaging of uniformly rotating targets based on the ExCoV method

The inverse synthetic aperture radar (ISAR) imaging can be converted into a sparse reconstruction problem and solved by the l1norm minimization algorithm. The basis matrix in sparse ISAR imaging is usually characterized by the unknown rotation rate of a moving target, thus the rotation rate and the sparse signal should be jointly estimated. Especially due to the imperfect coarse motion compensation, we consider the phase error correction problem in the context of the sparse signal reconstruction. To address this issue, we propose an iterative reweighted method, which jointly estimates the rotation rate, corrects the phase error and reconstructs a high resolution ISAR image. The proposed method gives a gradual and interweaved iterative process to refine the unknown parameters to achieve the best sparse representation for the ISAR signals. Particularly, in ISAR image reconstruction, the l1norm minimization algorithm is sensitive to user parameters. Setting these user parameters are not trivial and the reconstruction performance depends significantly on their choices. Then, we consider an expansion-compression variance-component (ExCoV) based method, which is automatic and demands no prior knowledge about signal-sparsity or measurement-noise levels. Both numerical and electromagnetic data experiments are implemented to show the effectiveness of the proposed method. It is shown that the proposed method can estimate the rotation rate and correct the phase errors simultaneously, and its superior performance is proved in terms of high resolution ISAR image. ? 2017 Beijing Institute of Aerospace Information.

Mg,Ti-base surface integrated layer and bulk doping to suppress lattice oxygen evolution of Ni-rich cathode material at a high cut-off voltage

The Nickel-rich layered cathode materials charged to 4.5 V can obtain a specific capacity of more than 200 m Ah g^(-1).However,the nickel-rich layered cathode materials suffer from the severe capacity fade during high-voltage cycling,which is related to the phase transformation and the surface sides reactions caused by the lattice oxygen evolution.Here,the simultaneous construction of a Mg,Ti-based surface integrated layer and bulk doping through Mg,Ti surface treatment could suppress the lattice oxygen evolution of Nirich material at deep charging.More importantly,Mg and Ti are co-doped into the particles surface to form an Mg_(2)TiO_(4) and Mg_(0.5–x)Ti_(2–y)(PO_(4))_(3) outer layer with Mg and Ti vacancies.In the constructed surface integrated layer,the reverse electric field in the Mg_(2)TiO_(4) effectively suppressed the outward migration of the lattice oxygen anions,while Mg_(0.5–x)Ti_(2–y)(PO_(4))_(3) outer layer with high electronic conductivity and good lithium ion conductor could effectively maintained the stability of the reaction interface during highvoltage cycling.Meanwhile,bulk Mg and Ti co-doping can mitigate the migration of Ni ions in the bulk to keep the stability of transition metal–oxygen(M-O)bond at deep charging.As a result,the NCM@MTP cathode shows excellent long cycle stability at high-voltage charging,which keep high capacity retention of 89.3%and 84.3%at 1 C after 200 and 100 cycles under room and elevated temperature of 25 and 55°C,respectively.This work provides new insights for manipulating the surface chemistry of electrode materials to suppress the lattice oxygen evolution at high charging voltage.

Angular extent effect of micromotion target in SAR image by polar format algorithm

Target micromotion not only plays an important role in target recognition but also leads to esoteric characteristics in synthetic aperture radar （SAR） imaging. This paper finds out an interesting phenomenon, i.e. the angular extent effect, in micro-motion target images formulated by the polar format algorithm. A micromotion target takes on multiple pairs of paired echoes （PEs） around the true point, and each PE extends for an angle which is exactly equal to the angular extent of the synthetic aperture, regardless of the micromotion frequency. The effect is derived and interpreted by using the characteristics of Bessel functions. Then it is demonstrated by simulation experiments of a target with different micromotion frequencies. The revelation and interpretation of the effect is highly beneficial to micromotion-target SAR image understanding as wel as target recognition.

Laser-Derived Interfacial Confinement Enables Planar Growth of 2D SnS_(2) on Graphene for High-Flux Electron/Ion Bridging in Sodium Storage

Establishing covalent heterointerfaces with face-to-face contact is promising for advanced energy storage,while challenge remains on how to inhibit the anisotropic growth of nucleated crystals on the matrix.Herein,faceto-face covalent bridging in-between the 2 D-nanosheets/graphene heterostructure is constructed by intentionally prebonding of laser-manufactured amorphous and metastable nanoparticles on graphene,where the amorphous nanoparticles were designed via the competitive oxidation of Sn-O and Sn-S bonds,and metastable feature was employed to facilitate the formation of the C-S-Sn covalent bonding in-between the heterostructure.The face-to-face bridging of ultrathin SnS;nanosheets on graphene enables the heterostructure huge covalent coupling area and high loading and thus renders unimpeded electron/ion transfer pathways and indestructible electrode structure,and impressive reversible capacity and rate capability for sodium-ion batteries,which rank among the top in records of the SnS_(2)-based anodes.Present work thus provides an alternative of constructing heterostructures with planar interfaces for electrochemical energy storage and even beyond.

Radar cross section of arbitrary polished spheres at terahertz frequencies

We develop an efficient method for polished metallic sphere’s scattering prediction in terahertz band when its frequency dispersion property is considered. By deducing scattering solution of the lossy metallic sphere, the radar cross section(RCS)of different metallic spheres is given at terahertz frequencies. The investigation of the RCS of polished metallic spheres shows the normalized RCS is always same to the metals’ normal incidence reflectivity when the sphere becomes electrically large. The metals which have high reflectivity(such as Al, Cu, Ag and Au) show that the corresponding RCS of the spheres is almost πa2 in terahertz band. The sphere’s RCS of the transition metal such as Fe begins to decrease obviously since the far infrared.

Construction of internal electric field to suppress oxygen evolution of Ni-rich cathode materials at a high cutoff voltage

The Nickel-rich layered cathode materials have been considered as promising cathode for lithium-ion batteries(LIBs),which due to it can achieve a high capacity of than 200 mAh g^(-1)under a high cutoff voltage of4.5 V.However,the nickel-rich layered cathode materials show severely capacity fading at high voltage cycling,induced by the hybrid O anion and cation redox promote O^(α-)(α<2)migration in the crystal lattice under high charge voltage,lead to the instability of the oxygen skeleton and oxygen evolution,promote the phase transition and electrolyte decomposition.Here,Li_(1-x)TMO_(2-y)/Li_(2)SO_(4) hybrid layer is designed by a simple pyrolysis method to enhance the high voltage cycle stability of NCM.In such constructed hybrid layer,the inner spinel structure of Li_(1-x)TMO_(2-y)layer is the electron-rich state,which could form an electron cloud coupling with the NCM with surface oxygen vacancies,while Li_(2)SO_(4) is p-type semiconductors,thus constructing a heterojunction interface of Li_(1-x)TMO_(2-y)//Li_(2)SO_(4) and Li_(1-x)TMO_(2-y)//NCM,thereby generating internal self-built electric fields to inhibit the outward migration of bulk oxygen anions.Moreover,the internal self-built electric fields could not only strengthen the bonding force between the Li_(1-x)TMO_(2-y)/Li_(2)SO_(4) hybrid layer and host NCM material,but also boost the charge transfer.As consequence,the modified NCM materials show excellent electrochemical performance with capacity retention of 97.7%and 90.1%after 200 cycles at 4.3 V and 4.5 V,respectively.This work provides a new idea for the development of high energy density applications of Nickel-rich layered cathode materials.

Three-dimensional oxygen-doped porous graphene:Sodium chloridetemplate preparation,structural characterization and supercapacitor performances

Supercapacitor is a new type of energy storage device,which has the advantages of high-power property and long cycle life.In this study,three-dimensional graphene(3 D-GN)with oxygen doping and porous structure was prepared from graphene oxide(GO)by an inexpensive sodium chloride(NaCl)template,as a promising electrode material for the supercapacitor.The structure,morphology,specific surface area,pore size,of the sample were characterized by XRD,SEM,TEM and BET techniques.The electrochemical performances of the sample were tested by CV and CDC techniques.The 3 D-GE product is a threedimensional nano material with hierarchical porous structures,its specific surface area is much larger than that of routine stacked graphene(GN),and it contains a large number of mesoporous and macropores,a small amount of micropores.The capacitance characteristics of the 3 D-GN electrode material are excellent,showing high specific capacitance(173.5 F·g^(-1)at 1 A·g^(-1)),good rate performance(109.2 F·g^(-1)at 8 A·g^(-1))and long cycle life(88%capacitance retention after 10,000 cycles at 8 A·g^(-1))

Primary urachal adenocarcinoma: a rare case report

Primary urachal carcinoma is a very rare cancer with a poor prognosis.It generally presents as a highgrade,high-stage tumor,and in most cases the patient has developed regional or distant metastasis at the time of presentation.Here,we report a very interesting case of primary urachal adenocarcinoma with signet ring cell carcinoma in a 58-year-old male who presented with a lower abdominal mass and discomfort.In this case,urachal carcinoma was successfully treated with surgery using an extended partial bladder cystectomy approach with excision of the urachal mass and umbilicus.The patient also underwent systematic chemotherapy with 5-fluorourical and cisplatin.During the 12-month follow-up period,the patient did not experience recurrence or metastasis.Overall,we found that an organ preserving extended partial cystectomy along with chemotherapy was an optimal treatment method that helped improve the patient's quality of the life with no recurrence of cancer so far.

Hydrated ammonium manganese phosphates by electrochemically induced manganese-defect as cathode material for aqueous zinc ion batteries

Aqueous zinc ion batteries(AZIBs) with the merits of low cost, low toxicity, high safety, environmental benignity as well as multi-valence properties as the large-scale energy storage devices demonstrate tremendous application prospect. However, the explorations for the most competitive manganese-based cathode materials of AZIBs have been mainly limited to some known manganese oxides. Herein, we report a new type of cathode material NH_(4)MnPO_(4)·H_(2)O(abbreviated as AMPH) for rechargeable AZIBs synthesized through a simple hydrothermal method. An in-situ electrochemical strategy inducing Mn-defect has been used to unlock the electrochemical activity of AMPH through the initial charge process, which can convert poor electrochemical characteristic of AMPH towards Zn^(2+)and NH_(4)+into great electrochemically active cathode for AZIBs. It still delivers a reversible discharge capacity up to 90.0 m Ah/g at 0.5 A/g even after 1000thcycles, which indicates a considerable capacity and an impressive cycle stability. Furthermore, this cathode reveals an(de)insertion mechanism of Zn^(2+)and NH_(4)+without structural collapse during the charge/discharge process. The work not only supplements a new member for the family of manganese-based compound for AZIBs, but also provides a potential direction for developing novel cathode material for AZIBs by introducing defect chemistry.