目的分析尘肺病患者在双肺大容量肺灌洗治疗前后生存质量变化情况。方法选择2016年4月—2019年10月在应急总医院住院接受双肺大容量肺灌洗治疗的67例尘肺病患者作为观察对象,通过问卷调查的方式,对尘肺病患者在灌洗前及灌洗后1个月和3...目的分析尘肺病患者在双肺大容量肺灌洗治疗前后生存质量变化情况。方法选择2016年4月—2019年10月在应急总医院住院接受双肺大容量肺灌洗治疗的67例尘肺病患者作为观察对象,通过问卷调查的方式,对尘肺病患者在灌洗前及灌洗后1个月和3个月分别进行世界卫生组织生活质量测定(WHO quality of life,WHOQOL-BREF)量表简表及自设一般情况量表测试,对其生存质量进行评定。结果接受双肺大容量肺灌洗治疗的尘肺病患者在灌洗后3个月对自身生存质量、自身健康状况评价以及在生理和心理领域及环境领域的得分优于灌洗后1个月,两者均优于灌洗前,差异均有统计学意义(均P<0.05)。生理领域灌洗前得分为13.96±1.17,灌洗后1个月得分为14.10±1.89,灌洗后3个月得分14.57±1.56,差异有统计学意义(P<0.01);心理领域灌洗前得分为13.79±1.37,灌洗后1个月得分为14.00±1.70,灌洗后3个月得分14.62±1.74,差异有统计学意义(P<0.01);社会领域灌洗前得分为15.18±1.14,灌洗后1个月得分为15.10±1.34,灌洗后3个月得分15.29±1.40,差异无统计学意义(P>0.05);环境领域灌洗前得分为11.75±1.40,灌洗后1个月得分为11.85±1.34,灌洗后3个月得分11.90±1.27,差异有统计学意义(P<0.05)。结论双肺大容量肺灌洗治疗短期内有利于改善尘肺病患者生存质量。展开更多
Background Real-time perfusion imaging （RTPI） using ultrasound contrast agents has shown good ＂accuracy＂ in detecting myocardial infarction, however its accuracy in the assessment of peri-infarct ischemia and stre...Background Real-time perfusion imaging （RTPI） using ultrasound contrast agents has shown good ＂accuracy＂ in detecting myocardial infarction, however its accuracy in the assessment of peri-infarct ischemia and stress echocardiography are not known. The aim of this study was to determine the accuracy of RTPI in assessment of peri-infarct ischemia during dobutamine and adenosine stress. Methods We employed the RTPI modality （Agilent and ATL Philips） in a canine model （18 dogs） of distal coronary occlusion and proximal coronary stenosis. Using coronary flow probe recordings, the physiologic significance of proximal coronary stenosis was established by confirming abolition of the coronary reserve. The contrast agent Optison was given as a slow bolus injection at baseline, during prolonged distal coronary occlusion, during adenosine bolus stress and during dobutamine stress. Triphenyltetrazolium chloride （TTC） staining was used to verity a distal infarction. RTPI recordings at baseline, the distal coronary occlusion and stress protocols were randomly mixed and reviewed blindly. Results In all but one dog, RTPI detected a distal infarct as small as 9% of the left ventricle. The sensitivity, specificity and overall diagnostic accuracy of RTPI in the detection of distal infarcts were： 94%, 89% and 92%, respectively. The sensitivity, specificity, and overall diagnostic accuracy of RTPI in the assessment of peri-infarction ischemia were 83%, 92% and 88% for adenosine stress and 95%, 86% and 91% for dobutamine stress, respectively. Conclusions Even small distal infarcts can be detected by RTPI; peri-infarct ischemia can be accurately recognized by RTPt during stress; adenosine and dobutamine stress appear equally reliable in the RTPI evaluation of peri-infarct ischemia.展开更多
文摘目的分析尘肺病患者在双肺大容量肺灌洗治疗前后生存质量变化情况。方法选择2016年4月—2019年10月在应急总医院住院接受双肺大容量肺灌洗治疗的67例尘肺病患者作为观察对象,通过问卷调查的方式,对尘肺病患者在灌洗前及灌洗后1个月和3个月分别进行世界卫生组织生活质量测定(WHO quality of life,WHOQOL-BREF)量表简表及自设一般情况量表测试,对其生存质量进行评定。结果接受双肺大容量肺灌洗治疗的尘肺病患者在灌洗后3个月对自身生存质量、自身健康状况评价以及在生理和心理领域及环境领域的得分优于灌洗后1个月,两者均优于灌洗前,差异均有统计学意义(均P<0.05)。生理领域灌洗前得分为13.96±1.17,灌洗后1个月得分为14.10±1.89,灌洗后3个月得分14.57±1.56,差异有统计学意义(P<0.01);心理领域灌洗前得分为13.79±1.37,灌洗后1个月得分为14.00±1.70,灌洗后3个月得分14.62±1.74,差异有统计学意义(P<0.01);社会领域灌洗前得分为15.18±1.14,灌洗后1个月得分为15.10±1.34,灌洗后3个月得分15.29±1.40,差异无统计学意义(P>0.05);环境领域灌洗前得分为11.75±1.40,灌洗后1个月得分为11.85±1.34,灌洗后3个月得分11.90±1.27,差异有统计学意义(P<0.05)。结论双肺大容量肺灌洗治疗短期内有利于改善尘肺病患者生存质量。
基金This study was supported by a grant from the National Natural Science Foundation of China （No. 30670875）.
文摘Background Real-time perfusion imaging （RTPI） using ultrasound contrast agents has shown good ＂accuracy＂ in detecting myocardial infarction, however its accuracy in the assessment of peri-infarct ischemia and stress echocardiography are not known. The aim of this study was to determine the accuracy of RTPI in assessment of peri-infarct ischemia during dobutamine and adenosine stress. Methods We employed the RTPI modality （Agilent and ATL Philips） in a canine model （18 dogs） of distal coronary occlusion and proximal coronary stenosis. Using coronary flow probe recordings, the physiologic significance of proximal coronary stenosis was established by confirming abolition of the coronary reserve. The contrast agent Optison was given as a slow bolus injection at baseline, during prolonged distal coronary occlusion, during adenosine bolus stress and during dobutamine stress. Triphenyltetrazolium chloride （TTC） staining was used to verity a distal infarction. RTPI recordings at baseline, the distal coronary occlusion and stress protocols were randomly mixed and reviewed blindly. Results In all but one dog, RTPI detected a distal infarct as small as 9% of the left ventricle. The sensitivity, specificity and overall diagnostic accuracy of RTPI in the detection of distal infarcts were： 94%, 89% and 92%, respectively. The sensitivity, specificity, and overall diagnostic accuracy of RTPI in the assessment of peri-infarction ischemia were 83%, 92% and 88% for adenosine stress and 95%, 86% and 91% for dobutamine stress, respectively. Conclusions Even small distal infarcts can be detected by RTPI; peri-infarct ischemia can be accurately recognized by RTPt during stress; adenosine and dobutamine stress appear equally reliable in the RTPI evaluation of peri-infarct ischemia.
