Because of the fingerprint-like specificity of its characteristic spectrogram, Raman spectral imaging has been applied widely in various research areas. Using a combination of structured illumination with the surface-...Because of the fingerprint-like specificity of its characteristic spectrogram, Raman spectral imaging has been applied widely in various research areas. Using a combination of structured illumination with the surface-enhanced Raman scattering(SERS) technique, wide-field Raman imaging is developed with a significant improvement in spatial resolution. As a result of the relatively narrow Raman characteristic peaks, optically encoded SERS nanoparticles can be used to perform multiplexed imaging. The results show excellent superresolution wide-field multiplexed imaging performance. The developed technique has extraordinary potential for applications in biological imaging and other related fields.展开更多
Tip-enhanced Raman scattering(TERS)spectroscopy is a nondestructive and label-free molecular detection approach that provides high sensitivity and nanoscale spatial resolution.Therefore,it has been used in a wide arra...Tip-enhanced Raman scattering(TERS)spectroscopy is a nondestructive and label-free molecular detection approach that provides high sensitivity and nanoscale spatial resolution.Therefore,it has been used in a wide array of applications.We demonstrate a gap-plasmon hybridization facilitated by a bottom-illuminated TERS configuration.The gap-plasmon hybridization effect is first performed with the finite-difference time-domain method to optimize the parameters,and experiments are then conducted to calibrate the performance.The results demonstrate an enhancement factor of 1157 and a spatial resolution of 13.5 nm.The proposed configuration shows great potential in related surface imaging applications in various fields of research.展开更多
基金National Natural Science Foundation of China(NSFC)(61490712,61427819,91750205,61605117)National Key Basic Research Program of China(973)(2015CB352004)+4 种基金Leading Talents of Guangdong Province Program(00201505)Natural Science Foundation of Guangdong Province(2016A030312010,2016A030310063,2017A030313351)National Key Research and Development Program of China(2016YFC0102401)Science and Technology Innovation Commission of Shenzhen(KQTD2017033011044403,KQTD2015071016560101,ZDSYS201703031605029)Excellent Young Teacher Program of Guangdong Province(YQ2014151)
文摘Because of the fingerprint-like specificity of its characteristic spectrogram, Raman spectral imaging has been applied widely in various research areas. Using a combination of structured illumination with the surface-enhanced Raman scattering(SERS) technique, wide-field Raman imaging is developed with a significant improvement in spatial resolution. As a result of the relatively narrow Raman characteristic peaks, optically encoded SERS nanoparticles can be used to perform multiplexed imaging. The results show excellent superresolution wide-field multiplexed imaging performance. The developed technique has extraordinary potential for applications in biological imaging and other related fields.
基金National Natural Science Foundation of China(61427819,91750205,11774256,61805154,61605117)Natural Science Foundation of Guangdong Province(2016A030312010)+1 种基金Leading Talents Program of Guangdong Province(00201505)Science and Technology Innovation Commission of Shenzhen(KQTD2017033011044403,ZDSYS201703031605029,JCYJ20180305125209538,JCYJ2017818144338999)。
文摘Tip-enhanced Raman scattering(TERS)spectroscopy is a nondestructive and label-free molecular detection approach that provides high sensitivity and nanoscale spatial resolution.Therefore,it has been used in a wide array of applications.We demonstrate a gap-plasmon hybridization facilitated by a bottom-illuminated TERS configuration.The gap-plasmon hybridization effect is first performed with the finite-difference time-domain method to optimize the parameters,and experiments are then conducted to calibrate the performance.The results demonstrate an enhancement factor of 1157 and a spatial resolution of 13.5 nm.The proposed configuration shows great potential in related surface imaging applications in various fields of research.
