Amnyotrophic lateral sderosis(ALS),also alled Lou Gchrig's disase,is an rreversible disase that is aused bythe degeneration and death of motor newons.Approximately 5-10%of cases are familial AIS(fALS),and the othe...Amnyotrophic lateral sderosis(ALS),also alled Lou Gchrig's disase,is an rreversible disase that is aused bythe degeneration and death of motor newons.Approximately 5-10%of cases are familial AIS(fALS),and the other cases are sporadic ALS(sALS).Gene mutations have been identifed both in fAIS and sALS patients.In this study,w disauss the four ALS-nelated genes,C9orf72,SODI,FUS,and TARDBP,and review the microRNAs(miRNAs)that are asociated with AlS and other neurological disordes from the litemature.A phylogentic analysis is used toexplore potential miRNAs that an be taken into acount when studying the dfference in pathology for AIS induced by the fowr genes and other ncurological discases such as frontotemporal dementia,spinal muscular atrophy,and narcolepsy.We found several miRNAs that an be taken into account to study the diference in pathology betwen AIS and other neurological disorders.展开更多
基金supported by the Ministry of Science and Technology 107-2118-M-009-002-MY2,Taiwan.
文摘Amnyotrophic lateral sderosis(ALS),also alled Lou Gchrig's disase,is an rreversible disase that is aused bythe degeneration and death of motor newons.Approximately 5-10%of cases are familial AIS(fALS),and the other cases are sporadic ALS(sALS).Gene mutations have been identifed both in fAIS and sALS patients.In this study,w disauss the four ALS-nelated genes,C9orf72,SODI,FUS,and TARDBP,and review the microRNAs(miRNAs)that are asociated with AlS and other neurological disordes from the litemature.A phylogentic analysis is used toexplore potential miRNAs that an be taken into acount when studying the dfference in pathology for AIS induced by the fowr genes and other ncurological discases such as frontotemporal dementia,spinal muscular atrophy,and narcolepsy.We found several miRNAs that an be taken into account to study the diference in pathology betwen AIS and other neurological disorders.
