目的探讨原发性高血压患者不同体位血浆醛固酮浓度(PAC)和脉压(PP)之间的相关性。方法连续选取2008年10月至2010年10月就诊于新疆维吾尔自治区高血压诊疗研究中心的高血压患者195例,所有受试者均成功完成立、卧、坐三体位刺激试验,分别...目的探讨原发性高血压患者不同体位血浆醛固酮浓度(PAC)和脉压(PP)之间的相关性。方法连续选取2008年10月至2010年10月就诊于新疆维吾尔自治区高血压诊疗研究中心的高血压患者195例,所有受试者均成功完成立、卧、坐三体位刺激试验,分别测量三体位的血压和PAC。按照平均PP划分为正常PP组(PP<40 mm Hg)和PP增大组(PP≥40 mm Hg),比较2组间临床指标的差异,分析PP与醛固酮水平的相关性。结果 (1)不同PP水平的2组间比较,PP≥40 mm Hg患者平均血钾水平明显高于PP<40 mm Hg患者(P=0.01)。相关分析提示,矫正了血清钾、年龄、性别后,PP和直立位PAC(r=0.235,P=0.001)、坐位PAC(r=0.220,P=0.002)及仰卧位PAC(r=0.166,P=0.021)均存在正相关。(3)2组间比较显示,不管任何体位,PP≥40 mm Hg患者PAC明显高于PP<40 mm Hg患者。直立位和坐位PAC>12 ng/dl患者比PAC≤12 ng/dl患者平均PP更大。(4)以PP是否≥40 mm Hg作为因变量,年龄、血钾、体重指数及三体位的PAC为自变量分别建立Logistics回归模型,分析发现血清K^+[OR=0.043,95%CI:1.09(1.00~1.12)]以及PAC[OR=0.025,95%CI:0.35(0.13~0.88)]均为PP增大的风险因素。结论无论是立位、坐位还是卧位,血清PAC水平增高和PP增大有一定的相关性,提示较高水平的PAC是高血压患者动脉弹性下降的危险因素。展开更多
The reaction of β,β-dicyanostyrene derivatives（l） with 1,3-dibromo-5,5-dimethylhydantoin（DBDMH） was systematicly studied. The reaction could generate different products when promoted by different mild bases. Whe...The reaction of β,β-dicyanostyrene derivatives（l） with 1,3-dibromo-5,5-dimethylhydantoin（DBDMH） was systematicly studied. The reaction could generate different products when promoted by different mild bases. When the reaction was promoted by NaOAc（100%, molar ratio to compound 1）, β,β-dicyanostyrene derivatives could be directly converted into corresponding α,β-dehydroamino derivatives in good to excellent yields in one-pot. When the reaction was promoted by K3PO4（80%, molar ratio to compound 1）, the corresponding α,β-dehydroamino and double-α,β-dehydroamino compounds were simultaneously obtained and the total conversion of β,β-dicyanostyrene derivatives was up to 90% or higher.展开更多
Arsenic （As） contamination has become the environment issue of global concern. In China, large area of farmland and the site soil were contaminated by As, which means that suitable remedying methods were urgently ne...Arsenic （As） contamination has become the environment issue of global concern. In China, large area of farmland and the site soil were contaminated by As, which means that suitable remedying methods were urgently needed. Phytoremediation, as one of environment-friendly soil remediation techniques developed in recent years, shows a bright future for the remediation of As contaminated soils. However, phytoremediation efficiency needs to be enhanced further because of low concentration of bio- available As in the soils. A triangle flask culture experiment was carried out to study the effects of functional species, isolated from As-polluted soils, that could improve As mobility from the soil. These species included two bacilli, B 1 and B2 （Breviba- cillus） and two fungi, F1 （Trichoderma）, F2 （Fusarium）. They could transform the concentration of As fractionation in the soil sterilized by the method of 6~Co-T ray. Through the experiment, the concentrations of non-specifically-sorbed and specifical- ly-sorbed As fractionation, and pH value of culture solution with inoculated treatment were higher than that with the control. Especially, the concentration of non-specifically-sorbed As fractionation in the treatment-inoculated species was 2 to 6 times higher than that of non-inoculation treatment. Moreover, two bacilli and two fungi could produce IAA, which was conducive to the plant survival when they were jointly used in remedying the As-contaminated soil.展开更多
文摘目的探讨原发性高血压患者不同体位血浆醛固酮浓度(PAC)和脉压(PP)之间的相关性。方法连续选取2008年10月至2010年10月就诊于新疆维吾尔自治区高血压诊疗研究中心的高血压患者195例,所有受试者均成功完成立、卧、坐三体位刺激试验,分别测量三体位的血压和PAC。按照平均PP划分为正常PP组(PP<40 mm Hg)和PP增大组(PP≥40 mm Hg),比较2组间临床指标的差异,分析PP与醛固酮水平的相关性。结果 (1)不同PP水平的2组间比较,PP≥40 mm Hg患者平均血钾水平明显高于PP<40 mm Hg患者(P=0.01)。相关分析提示,矫正了血清钾、年龄、性别后,PP和直立位PAC(r=0.235,P=0.001)、坐位PAC(r=0.220,P=0.002)及仰卧位PAC(r=0.166,P=0.021)均存在正相关。(3)2组间比较显示,不管任何体位,PP≥40 mm Hg患者PAC明显高于PP<40 mm Hg患者。直立位和坐位PAC>12 ng/dl患者比PAC≤12 ng/dl患者平均PP更大。(4)以PP是否≥40 mm Hg作为因变量,年龄、血钾、体重指数及三体位的PAC为自变量分别建立Logistics回归模型,分析发现血清K^+[OR=0.043,95%CI:1.09(1.00~1.12)]以及PAC[OR=0.025,95%CI:0.35(0.13~0.88)]均为PP增大的风险因素。结论无论是立位、坐位还是卧位,血清PAC水平增高和PP增大有一定的相关性,提示较高水平的PAC是高血压患者动脉弹性下降的危险因素。
基金Supported by the Natural Science Foundation of Shaanxi Province, China（No.2009JM2001）, the Innovation Foundation of Postgraduate Cultivation of Shaanxi Normal University, China（No.2008CXB009） and the Fundamental Research Funds for the Central Universities of China（No.GK261001095）.
文摘The reaction of β,β-dicyanostyrene derivatives（l） with 1,3-dibromo-5,5-dimethylhydantoin（DBDMH） was systematicly studied. The reaction could generate different products when promoted by different mild bases. When the reaction was promoted by NaOAc（100%, molar ratio to compound 1）, β,β-dicyanostyrene derivatives could be directly converted into corresponding α,β-dehydroamino derivatives in good to excellent yields in one-pot. When the reaction was promoted by K3PO4（80%, molar ratio to compound 1）, the corresponding α,β-dehydroamino and double-α,β-dehydroamino compounds were simultaneously obtained and the total conversion of β,β-dicyanostyrene derivatives was up to 90% or higher.
基金supported by the National Natural Science Foundation of China (Grant Nos. 21307080 and 41101232)Shanghai Knowledge Service Platform (Grant No. ZF1224)Key Discipline Construction Projects of Shanghai Second Polytechnic University (Grant No. XXKYS1404)
文摘Arsenic （As） contamination has become the environment issue of global concern. In China, large area of farmland and the site soil were contaminated by As, which means that suitable remedying methods were urgently needed. Phytoremediation, as one of environment-friendly soil remediation techniques developed in recent years, shows a bright future for the remediation of As contaminated soils. However, phytoremediation efficiency needs to be enhanced further because of low concentration of bio- available As in the soils. A triangle flask culture experiment was carried out to study the effects of functional species, isolated from As-polluted soils, that could improve As mobility from the soil. These species included two bacilli, B 1 and B2 （Breviba- cillus） and two fungi, F1 （Trichoderma）, F2 （Fusarium）. They could transform the concentration of As fractionation in the soil sterilized by the method of 6~Co-T ray. Through the experiment, the concentrations of non-specifically-sorbed and specifical- ly-sorbed As fractionation, and pH value of culture solution with inoculated treatment were higher than that with the control. Especially, the concentration of non-specifically-sorbed As fractionation in the treatment-inoculated species was 2 to 6 times higher than that of non-inoculation treatment. Moreover, two bacilli and two fungi could produce IAA, which was conducive to the plant survival when they were jointly used in remedying the As-contaminated soil.
