目的·既往研究发现乙型肝炎病毒(hepatitis B virus,HBV)感染会引起宿主脂蛋白改变,但脂蛋白亚类及其组分对HBV感染的应答规律未见报道。该研究拟通过定量分析HBV感染者的血清脂蛋白亚类及其组分,研究HBV感染引起的血清脂蛋白谱的...目的·既往研究发现乙型肝炎病毒(hepatitis B virus,HBV)感染会引起宿主脂蛋白改变,但脂蛋白亚类及其组分对HBV感染的应答规律未见报道。该研究拟通过定量分析HBV感染者的血清脂蛋白亚类及其组分,研究HBV感染引起的血清脂蛋白谱的变化特征。方法·纳入2017年3—6月就诊于华中科技大学同济医学院附属同济医院心内科的乙型肝炎病毒表面抗原阳性[HBsAg(+)]患者(n=40),同期纳入40例HBsAg阴性[HBsAg(-)]对照人群。使用核磁共振氢谱(proton nuclear magnetic resonance,1H-NMR)定量分析血清脂蛋白亚类及其组分,通过正交偏最小二乘判别分析、组间差异分析、逻辑回归分析和Spearman相关分析探索慢性HBV患者血清脂蛋白谱的变化规律。结果·HBsAg(+)组中大部分脂蛋白亚类及其组分水平显著低于HBsAg(-)组。校正年龄、性别、高血压、糖尿病以及心血管疾病因素后,总极低密度脂蛋白(very-lowdensitylipoprotein,VLDL)、VLDL1~VLDL3、中间密度脂蛋白(intermediate-densitylipoprotein,IDL)、小颗粒的高密度脂蛋白(small high-density lipoprotein 4,HDL4)和non-HDL及其组分依然是HBV感染的保护因素(OR<1,P<0.01),而VLDL5中的三酰甘油(triacylglycerol,TAG)占总脂质(total lipid,LP)的百分比[VLDL5-(TAG/LP)]则是HBV感染的危险因素(OR>1,P<0.01)。此外,HBsAg(+)人群的炎症程度与HDL4中的脂质组分水平高度负相关(r在-0.71~-0.51之间,P≤0.002)。通过特征筛选获得6个脂蛋白亚类指标,构建HBV感染诊断模型的AUC为0.861。结论·HBV感染影响肝脏分泌的脂蛋白的代谢转化,且脂蛋白亚类及其组分可用以区分HBV引起的表面抗原阳性患者。展开更多
After last year CNOOC's bidding for buy the US energy company Unocal Corp lost out to the Chevron Corporation, it conducted the crossing-border asset-acquirement again in the beginning of this year. On Jan. 9, 2006,C...After last year CNOOC's bidding for buy the US energy company Unocal Corp lost out to the Chevron Corporation, it conducted the crossing-border asset-acquirement again in the beginning of this year. On Jan. 9, 2006,CNOOC Ltd signed a definitive agreement with Nigeria South Atlantic Petroleum Limited (SAPETRO) to acquire a 45 % working interest in an offshore oil developing license OML 130 in Nigeria for US$2.268 billion cash. The purchase will be funded by the internal capital resources of CNOOC Ltd. In which, US$1.75 billion will pay for buying SAPETRO, and the remaining cash will be used to pay for the early operation cost.展开更多
New Urban Districts(NUDs)are the important spatial carriers to promote urban expansion or transformation.Since the 1990 s,they have been playing a more and more crucial role in China’s urbanization.For NUDs in the st...New Urban Districts(NUDs)are the important spatial carriers to promote urban expansion or transformation.Since the 1990 s,they have been playing a more and more crucial role in China’s urbanization.For NUDs in the strict sense we found that:96%to the east of Hu Line;56%within the municipal districts;64%within 36 km from their every city center and below the area of 423 km^2.The regional distribution follows significant spatial difference as"Eastern Region(50%)–Central Region(42%)–Western Region(8%)",and the provinces with the largest number of NUDs are Guangdong,Henan,Zhejiang,Liaoning,and Jiangsu.Furthermore,their interesting constructed process highlights the typical characteristics of spatial production and spatial dialectic.This paper uses the theory of the production of space,and discovers that the growth of NUDs is a rapid ternary dialectical process of spatial production:"representations of space"is guided by the top-down governmental power;"spatial practice"is reflected in the hierarchical and regional difference of spatial elements,such as the type,pattern,distance and area of NUD;"spaces of representation"embodies the tension between governmental power and urban development rights,as well as the countermeasure mechanism.The extensibility of spatiotemporal sequences ensures the unity and continuity of spatial(re)production of NUDs.However,this is also facing a series of challenges like the management coordination of administrative division and the increasing unbalanced or inadequate development.Thus,critically rethinking the evolution of NUD is the key basis for achieving sustainable urban renewal and regional orderly development in the new era.展开更多
文摘目的·既往研究发现乙型肝炎病毒(hepatitis B virus,HBV)感染会引起宿主脂蛋白改变,但脂蛋白亚类及其组分对HBV感染的应答规律未见报道。该研究拟通过定量分析HBV感染者的血清脂蛋白亚类及其组分,研究HBV感染引起的血清脂蛋白谱的变化特征。方法·纳入2017年3—6月就诊于华中科技大学同济医学院附属同济医院心内科的乙型肝炎病毒表面抗原阳性[HBsAg(+)]患者(n=40),同期纳入40例HBsAg阴性[HBsAg(-)]对照人群。使用核磁共振氢谱(proton nuclear magnetic resonance,1H-NMR)定量分析血清脂蛋白亚类及其组分,通过正交偏最小二乘判别分析、组间差异分析、逻辑回归分析和Spearman相关分析探索慢性HBV患者血清脂蛋白谱的变化规律。结果·HBsAg(+)组中大部分脂蛋白亚类及其组分水平显著低于HBsAg(-)组。校正年龄、性别、高血压、糖尿病以及心血管疾病因素后,总极低密度脂蛋白(very-lowdensitylipoprotein,VLDL)、VLDL1~VLDL3、中间密度脂蛋白(intermediate-densitylipoprotein,IDL)、小颗粒的高密度脂蛋白(small high-density lipoprotein 4,HDL4)和non-HDL及其组分依然是HBV感染的保护因素(OR<1,P<0.01),而VLDL5中的三酰甘油(triacylglycerol,TAG)占总脂质(total lipid,LP)的百分比[VLDL5-(TAG/LP)]则是HBV感染的危险因素(OR>1,P<0.01)。此外,HBsAg(+)人群的炎症程度与HDL4中的脂质组分水平高度负相关(r在-0.71~-0.51之间,P≤0.002)。通过特征筛选获得6个脂蛋白亚类指标,构建HBV感染诊断模型的AUC为0.861。结论·HBV感染影响肝脏分泌的脂蛋白的代谢转化,且脂蛋白亚类及其组分可用以区分HBV引起的表面抗原阳性患者。
文摘After last year CNOOC's bidding for buy the US energy company Unocal Corp lost out to the Chevron Corporation, it conducted the crossing-border asset-acquirement again in the beginning of this year. On Jan. 9, 2006,CNOOC Ltd signed a definitive agreement with Nigeria South Atlantic Petroleum Limited (SAPETRO) to acquire a 45 % working interest in an offshore oil developing license OML 130 in Nigeria for US$2.268 billion cash. The purchase will be funded by the internal capital resources of CNOOC Ltd. In which, US$1.75 billion will pay for buying SAPETRO, and the remaining cash will be used to pay for the early operation cost.
基金National Natural Science Foundation of China,No.41571138,No.41771171,No.41871143,No.41961029
文摘New Urban Districts(NUDs)are the important spatial carriers to promote urban expansion or transformation.Since the 1990 s,they have been playing a more and more crucial role in China’s urbanization.For NUDs in the strict sense we found that:96%to the east of Hu Line;56%within the municipal districts;64%within 36 km from their every city center and below the area of 423 km^2.The regional distribution follows significant spatial difference as"Eastern Region(50%)–Central Region(42%)–Western Region(8%)",and the provinces with the largest number of NUDs are Guangdong,Henan,Zhejiang,Liaoning,and Jiangsu.Furthermore,their interesting constructed process highlights the typical characteristics of spatial production and spatial dialectic.This paper uses the theory of the production of space,and discovers that the growth of NUDs is a rapid ternary dialectical process of spatial production:"representations of space"is guided by the top-down governmental power;"spatial practice"is reflected in the hierarchical and regional difference of spatial elements,such as the type,pattern,distance and area of NUD;"spaces of representation"embodies the tension between governmental power and urban development rights,as well as the countermeasure mechanism.The extensibility of spatiotemporal sequences ensures the unity and continuity of spatial(re)production of NUDs.However,this is also facing a series of challenges like the management coordination of administrative division and the increasing unbalanced or inadequate development.Thus,critically rethinking the evolution of NUD is the key basis for achieving sustainable urban renewal and regional orderly development in the new era.