Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutan...Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutants(e.g.,fine particulate matter:PM_(2.5);nitrogen dioxide:NO_(2);carbon monoxide,CO;or ozone:O_(3))have been widely explored^([4]).However,humans are constantly exposed to multipollutant mixtures in real life,and biological responses to inhaled pollutants are likely to depend on the interplay of pollutant mixtures.Therefore,it is critical and imperative to explore the joint effects of multipollutant mixtures on human beings.展开更多
目的模拟机体怡控制性失血性休克过程.以家兔为实验对象,探索不同浓度盐水(4.5%与7.5%)对非控制性失血性休克家兔肾脏功能及病理影响:方法将家兔随机分成5组,若实验过程家兔死亡,补充并保持每组有效家兔数址为8只分别为假手术组(SO组)...目的模拟机体怡控制性失血性休克过程.以家兔为实验对象,探索不同浓度盐水(4.5%与7.5%)对非控制性失血性休克家兔肾脏功能及病理影响:方法将家兔随机分成5组,若实验过程家兔死亡,补充并保持每组有效家兔数址为8只分别为假手术组(SO组)、休克未治疗组(SNT组)、生理盐水组(NS组).4.5%盐水组(4.5%,组).7.5%盐水组(7.5%,组),建必非控制性失血性休克模型,在设定时间,使用预设方案进行液体复苏,监测不同时间点(0 min .30 inin、60 min .90 min)家兔肾功能指标的变化情况.并在实验最后取心肺肾组织切片做HE染色观察结果SO组肾功指标较平稳,SNT组呈现缓慢匕升趋势,NS组给予液体复苏后各项指标呈现先上升后下降趋势,4.5%组和7.5%组给予液体复苏均后呈现下降的趋势.方差结果分析,各组家兔肾功指标BUN .Cr有显著性差异,11.7.5%组下降速度更快;NS组、4.5%组和7.5%组病理切片损伤明显轻于SNT组。结论高渗盐水对于失血性休克的救治效果要优于生理盐水.且7.5%浓度一定程度上优于4.5%浓度复苏效果,根据实验结果为临床液体复苏提供指导.可进一步研发一体化输注装备,指导与促进群体伤员现场的自救互救。展开更多
基金supported by the National Nature Science Foundation of China(42005136)Innovation Team Fund of Southwest Regional Meteorological Center+3 种基金China Meteorological Administration(XNQYCXTD-202203)China Postdoctoral Science(2020M670419)Key Research and Development program for Social Development in Yunnan Provincial(in China)(202203AC100006,202203AC100005)National Key Research and Development Program of China(2016YFA0602004)。
文摘Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutants(e.g.,fine particulate matter:PM_(2.5);nitrogen dioxide:NO_(2);carbon monoxide,CO;or ozone:O_(3))have been widely explored^([4]).However,humans are constantly exposed to multipollutant mixtures in real life,and biological responses to inhaled pollutants are likely to depend on the interplay of pollutant mixtures.Therefore,it is critical and imperative to explore the joint effects of multipollutant mixtures on human beings.
文摘目的模拟机体怡控制性失血性休克过程.以家兔为实验对象,探索不同浓度盐水(4.5%与7.5%)对非控制性失血性休克家兔肾脏功能及病理影响:方法将家兔随机分成5组,若实验过程家兔死亡,补充并保持每组有效家兔数址为8只分别为假手术组(SO组)、休克未治疗组(SNT组)、生理盐水组(NS组).4.5%盐水组(4.5%,组).7.5%盐水组(7.5%,组),建必非控制性失血性休克模型,在设定时间,使用预设方案进行液体复苏,监测不同时间点(0 min .30 inin、60 min .90 min)家兔肾功能指标的变化情况.并在实验最后取心肺肾组织切片做HE染色观察结果SO组肾功指标较平稳,SNT组呈现缓慢匕升趋势,NS组给予液体复苏后各项指标呈现先上升后下降趋势,4.5%组和7.5%组给予液体复苏均后呈现下降的趋势.方差结果分析,各组家兔肾功指标BUN .Cr有显著性差异,11.7.5%组下降速度更快;NS组、4.5%组和7.5%组病理切片损伤明显轻于SNT组。结论高渗盐水对于失血性休克的救治效果要优于生理盐水.且7.5%浓度一定程度上优于4.5%浓度复苏效果,根据实验结果为临床液体复苏提供指导.可进一步研发一体化输注装备,指导与促进群体伤员现场的自救互救。
