建立了抑制电导—离子色谱法用于直接测定手术用羧甲基壳聚糖中残留二甘醇酸。对比分析了3种不同离子交换色谱柱,结果表明:Shodex IC SI-524E阴离子分析柱性能最优。采用该分离柱,比较了不同的淋洗液浓度,最终选择8 mmol/L的碳酸钠溶液...建立了抑制电导—离子色谱法用于直接测定手术用羧甲基壳聚糖中残留二甘醇酸。对比分析了3种不同离子交换色谱柱,结果表明:Shodex IC SI-524E阴离子分析柱性能最优。采用该分离柱,比较了不同的淋洗液浓度,最终选择8 mmol/L的碳酸钠溶液为淋洗液。在确定的分离和洗脱条件下,该方法以20μL进样量对二甘醇酸的检出限为1.98μg/L,完全满足医药行业标准规范的要求,测定羧甲基壳聚糖样品中残留二甘醇酸的精密度(RSD=2.30%(n=7))和回收率(95.33%)也满足实际样品分析的要求。测试过程在15 min内可以完成,证明抑制电导—离子色谱法是测定羧甲基壳聚糖中残留二甘醇酸的一种简便、快速、准确的方法。展开更多
To solve the problem that the traditional location-based services anonymity model is not applied to the continuous query, quasi real-time cloak algorithm （QR-TCA） has been proposed, and the non-delay cloak model （N...To solve the problem that the traditional location-based services anonymity model is not applied to the continuous query, quasi real-time cloak algorithm （QR-TCA） has been proposed, and the non-delay cloak model （N-DCM） has been established. After comprehensive analysis of location-based continuous query privacy protection models, a model that can solve the user service delay problem is proposed, which can provide the users with quasi-real time location-based services. The experiment measures the N-DCM model with multiple dimensions, such as service response time and service quality of standard datasets. The experiment results show that the method is suitable for continuous query location privacy protection and can effectively protect the user’s location privacy.展开更多
文摘建立了抑制电导—离子色谱法用于直接测定手术用羧甲基壳聚糖中残留二甘醇酸。对比分析了3种不同离子交换色谱柱,结果表明:Shodex IC SI-524E阴离子分析柱性能最优。采用该分离柱,比较了不同的淋洗液浓度,最终选择8 mmol/L的碳酸钠溶液为淋洗液。在确定的分离和洗脱条件下,该方法以20μL进样量对二甘醇酸的检出限为1.98μg/L,完全满足医药行业标准规范的要求,测定羧甲基壳聚糖样品中残留二甘醇酸的精密度(RSD=2.30%(n=7))和回收率(95.33%)也满足实际样品分析的要求。测试过程在15 min内可以完成,证明抑制电导—离子色谱法是测定羧甲基壳聚糖中残留二甘醇酸的一种简便、快速、准确的方法。
基金Supported by the National Natural Science Foundation(61170035, 61272420)the Natural Science Foundation of Jiangsu Province(BK2011022, BK2011702)+2 种基金the Fundamental Research Funds for the Central Universities (30920130112006)Jiangsu Province Blue Project Innovation team,Nanjing science and technology project (020142010)Nanjing University of Science and Technology in 2009 Zijin Star Project Funding
文摘To solve the problem that the traditional location-based services anonymity model is not applied to the continuous query, quasi real-time cloak algorithm （QR-TCA） has been proposed, and the non-delay cloak model （N-DCM） has been established. After comprehensive analysis of location-based continuous query privacy protection models, a model that can solve the user service delay problem is proposed, which can provide the users with quasi-real time location-based services. The experiment measures the N-DCM model with multiple dimensions, such as service response time and service quality of standard datasets. The experiment results show that the method is suitable for continuous query location privacy protection and can effectively protect the user’s location privacy.
