Health risk associated with exposure to high-charge and -energy (HZE) particles in outer space has been discusseda lot mainly because its accurate assessment is complex and multifactorial[1??3]. Exponentially growing ...Health risk associated with exposure to high-charge and -energy (HZE) particles in outer space has been discusseda lot mainly because its accurate assessment is complex and multifactorial[1??3]. Exponentially growing cells are themost widely used in vitro model for risk assessment. However, majority of the cells in human body stay quiescent(in G0 phase) even though some cells, such as liver cells and stem cells, can resume cell cycle and enter G1 phase inresponse to exogenous stimuli such as injury[4]. Therefore, it is reasonable to use G0 cells as an in vitro experimentalmodel for risk assessment of space radiation.展开更多
文摘Health risk associated with exposure to high-charge and -energy (HZE) particles in outer space has been discusseda lot mainly because its accurate assessment is complex and multifactorial[1??3]. Exponentially growing cells are themost widely used in vitro model for risk assessment. However, majority of the cells in human body stay quiescent(in G0 phase) even though some cells, such as liver cells and stem cells, can resume cell cycle and enter G1 phase inresponse to exogenous stimuli such as injury[4]. Therefore, it is reasonable to use G0 cells as an in vitro experimentalmodel for risk assessment of space radiation.
