目的:探讨MRI水-脂分离Dixon技术对良恶性椎体压缩性骨折的鉴别诊断价值。方法 :收集因椎体压缩性骨折接受CT扫描且难以诊断的患者76例。均应用Siemens skyra 3.0 T MRI行常规矢状位T1WI、T2WI、STIR;T1WI Dixon序列获得同相位、反相位...目的:探讨MRI水-脂分离Dixon技术对良恶性椎体压缩性骨折的鉴别诊断价值。方法 :收集因椎体压缩性骨折接受CT扫描且难以诊断的患者76例。均应用Siemens skyra 3.0 T MRI行常规矢状位T1WI、T2WI、STIR;T1WI Dixon序列获得同相位、反相位、纯水相、纯脂相。根据临床随访或病理结果,76例中良性压缩性骨折43例(良性组),其中35例骨质疏松性骨折,5例创伤性骨折,3例感染性骨折;恶性压缩性骨折33例(恶性组),其中28例转移性骨折,3例非霍奇金淋巴瘤,2例多发性骨髓瘤。计算病变椎体信号强度指数(SIR)及脂肪分数(FF)。结果:良性组的FF值显著高于恶性组(P<0.01);良性组的SIR显著低于恶性组(P<0.01)。绘制FF及SIR对良恶性椎体压缩性骨折的诊断效能ROC曲线,FF和SIR鉴别良恶性椎体压缩性骨折的曲线下面积分别为0.79和0.88,最佳鉴别阈值分别为12.75%和0.86。结论:3.0 T MRI水-脂分离Dixon技术可定量测定椎体SIR和脂肪含量的变化,对椎体骨折性质的诊断和鉴别诊断具有重要的临床价值。展开更多
1-Methylpiperazine was employed to crystallize with 2,4-dihydroxybenzoic acid and 1,8-naphthalene acid, affording two multi-component hydrogen-bonding salts [（C5H14N2）^2＋-（C7H5O4）2^·H2O]（1） and [（C5H14N2...1-Methylpiperazine was employed to crystallize with 2,4-dihydroxybenzoic acid and 1,8-naphthalene acid, affording two multi-component hydrogen-bonding salts [（C5H14N2）^2＋-（C7H5O4）2^·H2O]（1） and [（C5H14N2）^2＋（C12H6O4）^2-.2H2O]（2）. These two forms of salts are both monoclinic systems with space group P21/c（14）. The lattice parameters of salts 1 and 2 are a=1.32666（10） nm, b=0.90527（7） nm, c=1.67107（13） nm, β=103.125（1）° and a=1.4950（2） nm, b=0.75242（15） nm, c=1.6563（3） nm, β=92.834（2）°, respectively. Expected classical hydrogen bonds N-H...O and O-H...O appear in the chargetransfer salts, and asymmetric units of these two forms both contain water molecules which play a significant role in building novel supramolecular architectures. Robust hydrogen-bond interactions between 1-methylpiperazine and aromatic acid provide sufficient driving force to direct the two crystals to three-dimensional structures. Weak interactions C-H-O emerging in salts 1 and 2 further enhance their crystal structures. As a consequence, hydrogen-bonding interactions in these compounds afford diverse 3D net supramolecular architectures. Thermal stability of these compounds was investigated by thermogravimetric analysis（TGA）.展开更多
文摘目的:探讨MRI水-脂分离Dixon技术对良恶性椎体压缩性骨折的鉴别诊断价值。方法 :收集因椎体压缩性骨折接受CT扫描且难以诊断的患者76例。均应用Siemens skyra 3.0 T MRI行常规矢状位T1WI、T2WI、STIR;T1WI Dixon序列获得同相位、反相位、纯水相、纯脂相。根据临床随访或病理结果,76例中良性压缩性骨折43例(良性组),其中35例骨质疏松性骨折,5例创伤性骨折,3例感染性骨折;恶性压缩性骨折33例(恶性组),其中28例转移性骨折,3例非霍奇金淋巴瘤,2例多发性骨髓瘤。计算病变椎体信号强度指数(SIR)及脂肪分数(FF)。结果:良性组的FF值显著高于恶性组(P<0.01);良性组的SIR显著低于恶性组(P<0.01)。绘制FF及SIR对良恶性椎体压缩性骨折的诊断效能ROC曲线,FF和SIR鉴别良恶性椎体压缩性骨折的曲线下面积分别为0.79和0.88,最佳鉴别阈值分别为12.75%和0.86。结论:3.0 T MRI水-脂分离Dixon技术可定量测定椎体SIR和脂肪含量的变化,对椎体骨折性质的诊断和鉴别诊断具有重要的临床价值。
基金Supported by the National Natural Science Foundation of China（Nos.51372125, 21203106）, the Fund of the State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, China（No.2013-34）, and the Scientific and Technical Development Project of Qingdao City, China（No. 13-1-4-184-jch）.
文摘1-Methylpiperazine was employed to crystallize with 2,4-dihydroxybenzoic acid and 1,8-naphthalene acid, affording two multi-component hydrogen-bonding salts [（C5H14N2）^2＋-（C7H5O4）2^·H2O]（1） and [（C5H14N2）^2＋（C12H6O4）^2-.2H2O]（2）. These two forms of salts are both monoclinic systems with space group P21/c（14）. The lattice parameters of salts 1 and 2 are a=1.32666（10） nm, b=0.90527（7） nm, c=1.67107（13） nm, β=103.125（1）° and a=1.4950（2） nm, b=0.75242（15） nm, c=1.6563（3） nm, β=92.834（2）°, respectively. Expected classical hydrogen bonds N-H...O and O-H...O appear in the chargetransfer salts, and asymmetric units of these two forms both contain water molecules which play a significant role in building novel supramolecular architectures. Robust hydrogen-bond interactions between 1-methylpiperazine and aromatic acid provide sufficient driving force to direct the two crystals to three-dimensional structures. Weak interactions C-H-O emerging in salts 1 and 2 further enhance their crystal structures. As a consequence, hydrogen-bonding interactions in these compounds afford diverse 3D net supramolecular architectures. Thermal stability of these compounds was investigated by thermogravimetric analysis（TGA）.
