基于优化第三代非支配排序遗传算法的城市应急设施模糊选址

以杭州市上城区2022年全年核酸检测点记录数据为基础,采用优化型第三代非支配排序遗传算法(NSGA3),将杭州市上城区划分为10786个50 m×50 m的人口点,模拟每个人口点去往周边核酸检测这一聚集性应急行为,并进行50000次迭代.将迭代结果进行核密度分析,分别得出基于单设施点的15 min生活圈优化结果、基于双设施点的15 min生活圈优化结果、基于适老化需求修正的设施点优化结果,以及基于单设施点的5 min生活圈优化结果.结果显示,以单设施点的15 min生活圈优化结果为例,在不改变服务能力的前提下,基于优化NSGA3迭代后的核酸检测点网络,将设施平均可达时间从292.44 s优化到了264.62 s.基于核酸检测这一行为结果形成城市应急设施的模糊选址范围,得出“小集聚-大分散”空间规律;在此基础上将模糊选址范围转化为“社区级多功能应急空间”,为将来发生应急事件,进行临时应急设施选点决策时提供理论建议.

中老年人群颈动脉斑块的预测模型构建及验证

目的通过构建并验证中老年人群颈动脉斑块的预测模型及对应用价值探讨。方法回顾性收集2017—2019年于上海交通大学医学院附属仁济医院内分泌科门诊完成颈动脉超声检查患者的临床资料,性别不限,年龄≥45岁。共纳入1416例样本,训练集993例,验证集423例。按照7∶3的比例随机分为训练集和验证集,在训练集中比较颈动脉斑块组与非颈动脉斑块组各临床指标差异,并将特征指标变量采用多因素Logistic回归分析确定颈动脉斑块发生的独立危险素,依次构建中老年人群颈动脉斑块发生风险的可视化列线图模型。通过校准曲线和受试者操作特征曲线(receiver operator characteristic curve,ROC曲线)验证模型的区分度、一致性和准确性,最后采用决策曲线分析法确定模型的临床实用性,并通过外部验证进行评估。结果最终本研究纳入1416例患者,有483例(34.11%)有颈动脉斑块。多因素Logistic回归分析结果显示,年龄、收缩压、γ-谷氨酰转肽酶、糖化血红蛋白是颈动脉斑块发生的危险因素,而相较于男性,女性是颈动脉斑块发生的保护因素。依此构建可视化列线图模型,训练集ROC曲线下面积(area under the curve,AUC)为0.75(95%CI:0.72~0.78),验证集ROC曲线的AUC为0.71(95%CI:0.66~0.76)。训练集与验证集校准曲线Hosmer-Lemeshow拟合优度检验显示P值均>0.05(训练集P=0.7501,验证集P=0.9872)。决策曲线结果显示预测模型在训练集和验证集的阈值概率分别为5%~98%和1%~81%。结论基于指标(性别、年龄、收缩压、谷氨酰转肽酶、糖化血红蛋白),成功建立了中老年人群颈动脉斑块发生风险的预测模型,该模型预测效能较好,可用于社区或者农村等偏远地区居民普查,有助于颈动脉斑块的早期识别,进而改善预后。

富马酸亚铁联合营养支持对营养不良儿童营养、免疫及血液指标的影响

目的探讨富马酸亚铁联合营养支持对营养不良儿童营养、免疫及血液指标的影响。方法前瞻性选取2020年1月至2023年6月烟台市烟台山医院收治100例的营养不良的患儿,按照随机数字方法分为对照组及研究组,各50例。研究组在营养支持基础上口服富马酸亚铁,对照组采用单纯营养支持,连续治疗4周。比较两组患儿治疗后临床疗效及不良反应,以及营养指标、血液指标及免疫指标水平。结果研究组患儿临床有效率(86.00%)明显高于对照组(68.00%),差异有统计学意义(χ^(2)=4.574,P=0.033)。治疗后,研究组患儿体质量指数(BMI)、转铁蛋白(TRF)及前清蛋白(PAB)、白蛋白、前白蛋白、血清铁(SI)、血红蛋白(Hb)及网织红细胞(Ret)水平明显高于对照组(P<0.05);IgA、IgG、IgE明显高于对照组(t=4.602,3.393,2.772,P<0.05),IgM水平明显低于对照组(t=3.805,P=0.001);两组患儿不良反应比较差异无统计学意义(P>0.05)。结论富马酸亚铁联合营养支持可显著提高营养不良患儿营养状态及免疫功能,改善铁代谢障碍及提高血红蛋白含量,且不良反应少,安全性较高,值得应用。

常州市主城区高强度降水变化特征及其影响分析

以常州市主城区为研究区域,基于高强度降水指数等指标,分析常州市主城区高强度降水特性及其对城市防汛的影响。研究结果表明,受气候变化和城镇化等影响,常州市主城区在1953—2022年期间有雨日数等3个极端降水日数指标、强降水量等6个高强度降水量级指标均呈递增趋势。

100T电炉电极调节控制系统升级改造

分析ET-DecNT电炉电极调节控制系统在使用寿命后期故障频发的原因,构建基于西门子S7-1500PLC硬件的电极调节系统,西门子S7-1500系列PLC构建电极调节系统设备运行稳定可靠,维护更加便捷。淘汰落后生产技术,采用先进的阻抗控制理念。计算变压器档位阻抗最佳工作点,优化冶炼控制模型,改善电极调节器的控制特性,提升电炉在不同冶炼阶段发挥最优电弧功率,提升电炉冶炼效率,节能降耗,同时解决原系统硬件淘汰断供问题。

Identification of novel genes associated with atherosclerosis in Bama miniature pig

Background:Atherosclerosis is a chronic cardiovascular disease of great concern.However,it is difficult to establish a direct connection between conventional small animal models and clinical practice.The pig's genome,physiology,and anatomy reflect human biology better than other laboratory animals,which is crucial for studying the pathogenesis of atherosclerosis.Methods:We used whole-genome sequencing data from nine Bama minipigs to perform a genome-wide linkage analysis,and further used bioinformatic tools to filter and identify underlying candidate genes.Candidate gene function prediction was performed using the online prediction tool STRING 12.0.Immunohistochemistry and immunofluorescence were used to detect the expression of proteins encoded by candidate genes.Results:We mapped differential single nucleotide polymorphisms(SNPs)to genes and obtained a total of 102 differential genes,then we used GO and KEGG pathway enrichment analysis to identify four candidate genes,including SLA-1,SLA-2,SLA-3,and TAP2.nsSNPs cause changes in the primary and tertiary structures of SLA-I and TAP2 proteins,the primary structures of these two proteins have undergone amino acid changes,and the tertiary structures also show slight changes.In addition,immunohistochemistry and immunofluorescence results showed that the expression changes of TAP2 protein in coronary arteries showed a trend of increasing from the middle layer to the inner layer.Conclusions:We have identified SLA-I and TAP2 as potential susceptibility genes of atherosclerosis,highlighting the importance of antigen processing and immune response in atherogenesis.

Corneal subepithelial nerve fibers in type 2 diabetes:potential biomarker of diabetic neuropathy

AIM:To observe the changes in corneal subepithelial nerve fibers(CNFs)and Langerhans cells(LCs)in patients with type 2 diabetes using corneal laser confocal microscopy(CLCM).METHODS:A total of 60 patients(64 eyes),including 40 patients with type 2 diabetes(DM group)and 20 subjects without diabetes(control group)were included with CLCM.Neuron J plugin of Image J software were used for quantitative analysis of CNF length(CNFL),CNF density(CNFD),corneal nerve branch fiber density(CNBD),main branch length density,branch length density,corneal nerve fiber tortuosity(NT)score,and LCs density.An independent samples t-test to analyze the variability between the two groups was performed,and Pearson correlation analysis was used to analyze the relationships between CNF and multiple biochemical indicators in the DM group.The predictive power of CNF for type 2 diabetes was assessed using the receiver operating characteristic(ROC)curve.RESULTS:There were significant differences in the CNFL,CNFD,and main branch length density between two groups.The results of Pearson correlation analysis showed a significant negative correlation between CNFD and the duration of diabetes as well as triglyceride levels and total cholesterol,and a significant positive correlation between CNFD and serum albumin.In addition,the NT score showed a positive correlation and urea nitrogen,similar to the positive correlation observed between LC density and glycosylated hemoglobin(HbA1c)levels.CNFD showed the highest area under the curve(AUC of ROC)value,followed by main branch length density and CNFL.The AUC of the ROC curve under the logistic regression model also demonstrated good predictive values.The cut-off values of CNFD,CNFL,and main branch length density for diabetes showed 31.25,18.85,and 12.56,respectively.CONCLUSION:In patients with type 2 diabetes,there is a notable reduction in both CNFL and CNFD.These measurements can be influenced by various blood biochemical factors.However,the compromised nerve fibers can serve as valuable indicators for predicting the onset of type 2 diabetes and also as biomarkers for detecting diabetic neuropathy and its related complications.

Preliminary study of metabonomic changes during the progression of atherosclerosis in miniature pigs

Background:To explore potential biomarkers for early diagnosis of atherosclerosis(AS)and provide basic data for further research on AS,the characteristics of serum metabolomics during the progression of AS in mini-pigs were observed dynamically.Methods:An AS model in Bama miniature pigs was established by a high-cholesterol and high-fat diet.Fasting serum samples were collected monthly for metabolomics and serum lipid detection.At the end of the treatment period,pathological analysis of the abdominal aorta and coronary artery was performed to evaluate the lesions of AS,thereby distinguishing the susceptibility of mini-pigs to AS.The metabolomics was de-tected using a high-resolution untargeted metabolomic approach.Statistical analysis was used to identify metabolites associated with AS susceptibility.Results:Based on pathological analysis,mini-pigs were divided into two groups:a susceptible group(n=3)and a non-susceptible group(n=6).A total of 1318 metabo-lites were identified,with significant shifting of metabolic profiles over time in both groups.Dynamic monitoring analysis highlighted 57 metabolites that exhibited an ob-vious trend of differential changes between two groups with the advance of time.The KEGG(Kyoto Encyclopedia of Genes and Genomes)pathway enrichment analysis in-dicated significant disorders in cholesterol metabolism,primary bile acid metabolism,histidine metabolism,as well as taurine and hypotaurine metabolism.Conclusions:During the progression of AS in mini-pigs induced by high-cholesterol/high-fat diet,the alterations in serum metabolic profile exhibited a time-dependent pattern,accompanied by notable disturbances in lipid metabolism,cholesterol me-tabolism,and amino acid metabolism.These metabolites may become potential bio-markers for early diagnosis of AS.

Clinical effect of laparoscopic radical resection of colorectal cancer based on propensity score matching

BACKGROUND The incidence of colorectal cancer(CRC)is increasing annually.Laparoscopic radical resection of CRC is a minimally invasive procedure preferred in clinical practice.AIM To investigate the clinical effect of laparoscopic radical resection of CRC on the basis of propensity score matching(PSM).METHODS The clinical data of 100 patients who received inpatient treatment for CRC at Changde Hospital,Xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)were analyzed retrospectively.The control group included patients who underwent open surgery(n=43),and those who underwent laparoscopic surgery formed the observation group(n=57).The baseline information of both groups was equipoised using 1×1 PSM.Differences in the perioperative parameters,inflammatory response,immune function,degree of pain,and physical status between the groups were analyzed.RESULTS Thirty patients from both groups were successfully matched.After PSM,baseline data showed no statistically significant differences between the groups:(1)Periop-erative parameters:The observation group had a longer surgery time,less intra-operative blood loss,earlier first ambulation and first anal exhaust times,and shorter gastric tube indwelling time than the control group;(2)Inflammatory response:24 h after surgery,the levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)between groups were higher than preoperatively.IL-6,CRP,and TNF-αlevels in the observation group were lower than in the control group;(3)Immune function:At 24 h after surgery,counts of CD4-positive T-lymphocytes(CD4+)and CD4+/CD8-positive T-lymphocytes(CD8+)in both groups were lower than those before surgery,whereas CD8+was higher than that before surgery.At 24 h after surgery,both CD4+counts and CD4+/CD8+in the observation group were higher than those in the control group,whereas CD8+counts were lower;(4)Degree of pain:The visual analog scale scores in the observation group were lower than those in the control group at 24 and 72 h after surgery;and(5)Physical status:One month after surgery,the Karnofsky performance score in the observation group was higher than that in the control group.CONCLUSION Laparoscopic radical resection of CRC has significant benefits,such as reducing postoperative pain and postoperative inflammatory response,avoiding excessive immune inhibition,and contributing to postoperative recovery.

社会互构视域下女性在城市社区治理的参与

女性群体作为参与城市社区治理的主力军,凭借其自身优势及参与城市社区治理的积极性助推社区治理共同体建设。基于对南昌市S社区观察可知,女性作为城市社区的使用者、服务者和支持者,通过志愿性参与、娱乐性参与及民主协商性参与的方式,凝聚女性力量,培育社群感,通过情感联结,将“陌生人社区”联结起来,实现城市社区整合,充分体现了女性群体在参与社区治理过程中的组织优势、增能优势和补位优势。社区女性社会组织的成立,扩大了女性自主性参与城市社区治理的参与途径与空间,同时也对女性个人参与能力提出更高诉求。女性在城市社区活动中得到锻炼,在提高自身社会参与能力的同时,也为建设社区治理共同体贡献力量。

新疆盖孜水电站钢岔管安装焊接工艺

水电站工程之复杂性和特殊性决定了所涉及的工程设备和构件也拥有着独特的设计和安装需求。其中,钢岔管的设计、安装与焊接是重要构成部分,事关最终工程的质量与安全性。而随着科技的进步,优化这些步骤的可能性和方法也显得日益重要。文章对这些关键环节进行详细的探讨和分析,从中提取出实践中得到的经验教训,并提供相应的优化建议。

开放系统下方解石除氟机制的主导性界定研究

方解石除氟机制主要涉及表面吸附和沉淀2个方面,宏观界定以上2种机制在除氟过程中的主导性,对氟去除后的稳定性评估有重要意义。文章采用批量平衡法,在不同pH、时间、氟浓度等条件下,对开放体系中方解石除氟机制的主导性进行界定研究。结果表明:(1)在pH8.3条件下,初始氟浓度≤40 mg/L,表面吸附为氟去除的主导机制,该反应3 h内便基本完成;初始氟浓度≥60 mg/L,CaF_(2)沉淀反应作为除氟的主导机制,该主导性在3 h后已体现出来,24 h后反应仍未达到平衡;Langmuir和Freundlich模型拟合结果与上述结果一致。(2)在pH7.7条件下,初始氟浓度≤10 mg/L,表面吸附作为除氟的主导机制,反应在3 h内也基本完成;当初始氟浓度≥25mg/L时,氟去除的主导机制为CaF_(2)沉淀反应,对应Ca浓度和pH值的变化趋势印证了该沉淀反应的主导性,3 h后反应基本完成。(3)在pH7.3条件下,初始氟浓度≤5 mg/L时,氟去除的主导机制为表面吸附,该反应在3 h内也基本完成;当初始氟浓度≥10 mg/L,氟去除的主导机制已转变为沉淀反应,反应在3 h内也基本完成,与pH7.7条件时类似。对应的Ca浓度和pH值并未产生重大变化,与pH7.7时情况不同。(4)氟的去除率结果指出,不管反应3 h还是24 h后,氟的去除率曲线总出现拐点,暗示了氟去除的主导机制由表面吸附向沉淀转变,与上述氟去除动力学结果一致。通过对2种除氟机制主导性的宏观界定,为今后氟的迁移稳定性研究提供借鉴。

未来城市空间的虚实关系:基于技术的演进

过去,城市空间的认知多从实体维度的不同方面展开,但随着数字技术的发展,虚拟维度也将成为城市规划领域空间认知的重要视角,且技术的演进影响着城市空间的虚实关系。通过对不同数字技术作用下的空间特性进行分析与对比,发现由于XR技术在交互内容与方式上的改变催生了虚实空间,虚实空间具有可视性、三维空间感、可与实体环境实时交互等特点。进一步对数字技术影响下城市空间的不同虚实关系进行分析:包括实体空间向虚拟空间的转移、实体空间对虚拟空间的承接、虚实空间对虚拟空间的补充、以及实体空间对虚实空间的配合。其中,虚实空间将对城市区域联系、城市公共空间造成影响。未来城市空间的虚实关系将影响城市规划与设计:城市空间的虚实双重属性将对规划师提出双重要求,城市空间的虚实交互将改变规划设计过程的进行。随着影响的进一步深入,后续还需探讨如何既保护实体空间又规范虚拟、虚实空间的设计、存储和使用,并关注社会关系、社会经济的变化。

网络时代文化资源资本化对乡村发展的两重性

从乡村文化资源资本化的角度,对互联网时代的乡村新型发展产物网红村的形成机制、模式演变和其对乡村健康发展的利弊影响进行研究。构建网红村文化资源资本化的分层逻辑框架,包括:基于市场与规划的乡村文化资源资本化;乡村符号塑造与传播的虚拟空间;从属于乡村虚拟空间形象塑造的实体空间;新型多元参与主体的关系。研究发现,城市消费需求的演变已成为网络时代乡村文化资源资本化的方向指引,并且在这一过程中存在较强的消费者主体性。因此,为促进文化资源资本化对乡村发展的正向作用,提出基于乡村与村民主体性的发展方式,以此构建乡村各项资本间的平衡与健康。

老旧小区户外活动空间品质提升规划方法探索——以杭州市王马社区南片老旧小区为例

在城市空间从增量发展转向存量挖潜的大背景下,城镇老旧小区改造对推动城市品质提升具有重要意义。户外活动空间作为住区内塑造公共环境的重要内容,居住区规划设计标准仅对其提出面积管控要求,缺乏多方面设计要素的具体准则。该文针对当前老旧小区户外活动空间存在的布局不合理、总量欠缺、分级不明确和吸引力不足等典型问题,从空间布局、空间规模数量、空间等级功能和空间吸引力4个维度共计9个指标构建了老旧小区户外活动空间品质提升的规划设计框架,引入空间句法、图像识别等量化分析方法。并以杭州市中心区王马社区南片老旧小区规划方案为例,运用框架探讨其规划合理性,分析其中存在的问题并提出优化建议,以期为其他老旧小区构建高品质户外活动空间提供理论指导与规划实践参考。

Bexarotene improves motor function after spinal cord injury in mice

Spinal cord injury is a challenge in orthopedics because it causes irreversible damage to the central nervous system.Therefore,early treatment to prevent lesion expansion is crucial for the management of patients with spinal cord injury.Bexarotene,a type of retinoid,exerts therapeutic effects on patients with cutaneous T-cell lymphoma and Parkinson's disease.Bexarotene has been proven to promote autophagy,but it has not been used in the treatment of spinal cord injury.To investigate the effects of bexarotene on spinal cord injury,we established a mouse model of T11–T12 spinal cord contusion and performed daily intraperitoneal injection of bexarotene for 5 consecutive days.We found that bexarotene effectively reduced the deposition of collagen and the number of pathological neurons in the injured spinal cord,increased the number of synapses of nerve cells,reduced oxidative stress,inhibited pyroptosis,promoted the recovery of motor function,and reduced death.Inhibition of autophagy with 3-methyladenine reversed the effects of bexarotene on spinal cord injury.Bexarotene enhanced the nuclear translocation of transcription factor E3,which further activated AMP-activated protein kinase-S-phase kinase-associated protein 2-coactivator-associated arginine methyltransferase 1 and AMP-activated protein kinase-mammalian target of rapamycin signaling pathways.Intravenous injection of transcription factor E3 sh RNA or intraperitoneal injection of compound C,an AMP-activated protein kinase blocker,inhibited the effects of bexarotene.These findings suggest that bexarotene regulates nuclear translocation of transcription factor E3 through the AMP-activated protein kinase-Sphase kinase-associated protein 2-coactivator-associated arginine methyltransferase 1 and AMP-activated protein kinase-mammalian target of rapamycin signal pathways,promotes autophagy,decreases reactive oxygen species level,inhibits pyroptosis,and improves motor function after spinal cord injury.

Long-term and short-term stability characteristics of receiver inter system bias for BDS3/BDS2

The study of inter-system bias(ISB)is important for multi-system fusion and the performance of different signal compatibility.In this paper,the stability of ISB at the BDS3/BDS2 receiver end is calculated and analyzed for different time spans(DOY 060~090 in 2021)from a total of 31 MGEX and iGMAS stations.We adopted two estimation strategies,random walk and constant approach,using the precision products of orbit and clock bias provided by WUM,the influence of which on ISB was also analyzed.Our results showed that the ISB value varied little within a day,and the mean of daily ISB standard deviation was only 0.037 m when the observation condition was good.The signal reception was continuous,indicating a high ISB stability for one day.If extending the time series to one month,however,the ISB standard deviation calculated by constant approach,in which a constant ISB is estimated on a daily basis was about 0.1 m,and the results of adjacent days were not continuous,with no apparent pattern.Concerning the random walk approach,the obtained ISB time series also had a jump,and the conclusion was the same as that of the constant strategy.Besides,receiver types showed a strong regularity in ISB numerical situation,and the distribution of ISB values corresponding to the same receiver type was relatively close.Therefore,we conclude that the ISB parameters remain stable in the short term(one day)and less stable in the long-term period.It is recommended that the ISB term should be set as a constant estimate every day in BDS3/BDS2 solutions,regardless of receiver type consistency.

Alternation of the Atmospheric Teleconnections Associated with the Northeast China Spring Rainfall during a Recent 60-Year Period

Northeast China(NEC)is China’s national grain production base,and the local precipitation is vital for agriculture during the springtime.Therefore,understanding the dynamic origins of the NEC spring rainfall(NECSR)variability is of socioeconomic importance.This study reveals an interdecadal change in the atmospheric teleconnections associated with the NECSR during a recent 60-year period(1961-2020).Before the mid-1980s,NECSR had been related to a Rossby wave train that is coupled with extratropical North Atlantic sea surface temperature(SST),whereas,since the mid-1980s,NECSR has been linked to a quite different Rossby wave train that is coupled with tropical North Atlantic SST.Both Rossby wave trains could lead to enhanced NECSR through anomalous cyclones over East Asia.The weakening of the westerly jet over North America is found to be mainly responsible for the alternation of the atmospheric teleconnections associated with NECSR during two epochs.

Whole-genome sequencing study to identify candidate markers indicating susceptibility to type 2 diabetes in Bama miniature pigs

Background:Hundreds of single-nucleotide polymorphism(SNP)sites have been found to be potential genetic markers of type 2 diabetes mellitus(T2DM).However,SNPs related to T2DM in minipigs have been less reported.This study aimed to screen the T2DM-susceptible candidate SNP loci in Bama minipigs so as to improve the success rate of the minipig T2DM model.Methods:The genomic DNAs of three Bama minipigs with T2DM,six sibling lowsusceptibility minipigs with T2DM,and three normal control minipigs were compared by whole-genome sequencing.The T2DM Bama minipig-specific loci were obtained,and their functions were annotated.Meanwhile,the Biomart software was used to perform homology alignment with T2DM-related loci obtained from the human genome-wide association study to screen candidate SNP markers for T2DM in Bama miniature pigs.Results:Whole-genome resequencing detected 6960 specific loci in the minipigs with T2DM,and 13 loci corresponding to 9 diabetes-related genes were selected.Further,a set of 122 specific loci in 69 orthologous genes of human T2DM candidate genes were obtained in the pigs.Collectively,a batch of T2DM-susceptible candidate SNP markers in Bama minipigs,covering 16 genes and 135 loci,was established.Conclusions:Whole-genome sequencing and comparative genomics analysis of the orthologous genes in pigs that corresponded to the human T2DM-related variant loci successfully screened out T2DM-susceptible candidate markers in Bama miniature pigs.Using these loci to predict the susceptibility of the pigs before constructing an animal model of T2DM may help to establish an ideal animal model.

Modulation of Steady-State Heat Transport in a Dissipative Multi-Mode Qubit-Photon System

Quantum heat transport is considered as an indispensable branch of quantum thermodynamics to potentially improve performance of thermodynamic devices.We theoretically propose a dissipative qubit-photon system composed of multiple coupled resonators interacting with a single two-level qubit,to explore the steady-state heat transport by tuning both the inter-resonator photon hopping and the qubit-photon coupling.Specifically in the three-mode case,the dramatic enhancement and suppression of the heat current into the central resonator can be modulated by the corresponding frequency,compared to the currents into two edge resonators.Moreover,fruitful cycle current components are unraveled at weak qubit-photon coupling,which are crucial to exhibit the nonmonotonic feature with increase of the reservoir temperature bias.In the one-dimensional case under the mean-field framework,the influence of the photon hopping on heat transport is analyzed.The steady-state heat current is comparatively enhanced to the single-mode limit at weak qubit-photon coupling,stemming from the nonvanishing mean-field photon excitation parameter and the additional cycle current component.We hope these obtained results may have possible applications in quantum thermodynamic manipulation and energy harvesting.