Multidimensional optical tweezers synthetized by rigid-body emulated structured light

Structured light with more extended degrees of freedom(DoFs)and in higher dimensions is increasingly gaining traction and leading to breakthroughs such as super-resolution imaging,larger-capacity communication,and ultraprecise optical trapping or tweezers.More DoFs for manipulating an object can access more maneuvers and radically increase maneuvering precision,which is of significance in biology and related microscopic detection.However,manipulating particles beyond three-dimensional(3D)spatial manipulation by using current all-optical tweezers technology remains difficult.To overcome this limitation,we theoretically and experimentally present six-dimensional(6D)structured optical tweezers based on tailoring structured light emulating rigid-body mechanics.Our method facilitates the evaluation of the methodology of rigid-body mechanics to synthesize six independent DoFs in a structured optical trapping system,akin to six-axis rigid-body manipulation,including surge,sway,heave,roll,pitch,and yaw.In contrast to previous 3D optical tweezers,our 6D structured optical tweezers significantly improved the flexibility of the path design of complex trajectories,thereby laying the foundation for next-generation functional optical manipulation,assembly,and micromechanics.

Trends on medicine use in county public hospitals in Sanming,China from 2011 to 2017

Sanming model in healthcare reform has attracted much attention due to its comprehensive and efficient exploration,while its impact on physicians’prescribing behavior remains unknown.In the present study,we aimed to evaluate the impact of Sanming reform on physicians’medicine use in county-level public hospitals.We collected outpatient prescriptions in the internal medicine and pediatric departments from nine county public hospitals in Sanming from January 2011 to December 2017.We used six prescribing indicators to analyze physicians’medicine use.The Mann-Kendall test was used to examine trends in the study outcomes.A total of 1577904 outpatient prescriptions were included in this study.The average prescription rate of antibiotics and combined antibiotics were 57.5%and 12.2%in 2011,respectively,which were declined to 28.2%(P=0.007)and 2.9%(P=0.003)in 2017,respectively.The average prescription rate of injection was 30.2%in 2011 and declined to 5.3%(P=0.003)in 2017.As for the subgroup analysis of the internal medicine and pediatric departments,the average prescription rate of antibiotics was 39.3%and 71.4%in 2011,respectively,which was declined to 10.2%(P=0.003)and 47.3%(P=0.035)in 2017,respectively.The average prescription rate of combined antibiotics was 15.9%and 9.4%in 2011,respectively,which was declined to 2.9%(P=0.003)and 2.9%(P=0.016),respectively.The average prescription rate of injection was 17.8%and 39.6%in 2011,respectively,which was declined to 1.9%(P=0.003)and 9.0%(P=0.003),respectively.Our study showed a significant decreasing trend in antibiotic use in county-level public hospitals after the Sanming healthcare reform,indicating that the reform successfully promoted the appropriate use of medicine to some extent.