骨髓增生异常肿瘤(myelodysplastic neoplasms,MDS)患者的预后与其细胞遗传学和分子遗传学特征密切相关,TP53基因作为MDS最常见的突变基因之一,其异常是MDS独立的不良预后因素以及向急性髓系白血病(acute myeloid leuke⁃mia,AML)转化的...骨髓增生异常肿瘤(myelodysplastic neoplasms,MDS)患者的预后与其细胞遗传学和分子遗传学特征密切相关,TP53基因作为MDS最常见的突变基因之一,其异常是MDS独立的不良预后因素以及向急性髓系白血病(acute myeloid leuke⁃mia,AML)转化的危险因素之一。新近更新的第5版世界卫生组织血液淋巴肿瘤分类标准(the 5th edition of the who classifica⁃tion of haematolymphoid tumours,WHO 2022)以及髓系肿瘤和急性白血病的国际共识分类(international consensus classification of myeloid neoplasms and acute leukemia,ICC)将伴有TP53双等位基因失活(biallelic TP53 inactivation,biTP53)的MDS作为独立的亚型列出,该亚型患者预后极差,生存期极短。目前针对伴TP53基因异常的MDS患者的治疗尚未能有效改善该类患者预后,新型靶向药物、免疫治疗等均在探索中,本文就国内外对伴TP53基因异常的MDS的临床研究进展进行综述。展开更多
Using the observations from ICOADS datasets and contemporaneous NCEP/NCAR reanalysis datasets during 1960-2002,the study classifies the airflows in favor of sea fog over the Huanghai （Yellow） Sea in boreal spring （...Using the observations from ICOADS datasets and contemporaneous NCEP/NCAR reanalysis datasets during 1960-2002,the study classifies the airflows in favor of sea fog over the Huanghai （Yellow） Sea in boreal spring （April-May） with the method of trajectory analysis,and analyzes the changes of proportions of warm and cold sea fogs along different paths of airflow.According to the heat balance equation,we investigate the relationships between the marine meteorological conditions and the proportion of warm and cold sea fog along different airflow paths.The major results are summarized as follows.（1） Sea fogs over the Huanghai Sea in spring are not only warm fog but also cold fog.The proportion of warm fog only accounts for 44% in April,while increases as high as 57% in May.（2） Four primary airflow paths leading to spring sea fog are identified.They are originated from the northwest,east,southeast and southwest of the Huanghai Sea,respectively.The occurrence ratios of the warm sea fog along the east and southeast airflow paths are high of 55% and 70%,while these along the southwest and northwest airflow paths are merely 17.9% and 50%.（3） The key physical processes governing the warm/cold sea fog are heat advection transport,longwave radiation cooling at fog top,solar shortwave warming and latent heat flux between airsea interfaces.（4） The characteristics of sea fog along the four airflow paths relate closely to the conditions of water vapor advection,and the vertical distribution of relative humidity.展开更多
The best track dataset of tropical cyclones in the western North Pacific （WNP） and the South China Sea （SCS） from 1977 to 2005 during the satellite era, the NCEP/NCAR reanalysis dataset and the extended reconstruc...The best track dataset of tropical cyclones in the western North Pacific （WNP） and the South China Sea （SCS） from 1977 to 2005 during the satellite era, the NCEP/NCAR reanalysis dataset and the extended reconstructed sea surface temperature dataset are employed in this study. The main climatological characteristics of tropical cyclone formation over the WNP and the SCS are compared. It is found that there is obviously different for the locations of tropical cyclone origins, achieving the lowest central pressure and termination points between over the WNP and over the SCS. The annual number of tropical cyclones forming over the SCS is obviously less than over the WNP, and there is a significant negative correlation with the correlation coefficient being - 0.36 at the 5% significance level between over the WNP and over the SCS. The mean speed of tropical cyclone moving is 6.5 m/s over the WNP and 4.6 m/s over the SCS. The mean lowest central pressure of tropical cyclones is obviously weaker over the SCS than over the WNP. The tropical cyclone days per year, mean total distance and total displacement of tropical cyclone traveled over the WNP are all obviously longer than those over the SCS. Tropical cyclone may intensify to Saffir - Simpson hurricane scale 5 over the WNP, but no tropical cyclone can intensify to Saffir - Simpson hurricane scale 3 over the SCS. The changing ranges of the radii （R15,R16） of the 15.4 m/s winds them and the 25.7 m/s winds over the WNP are obviously wider than those over the SCS, and the median values of the radii over the WNP are also larger than those over the SCS. For the same intensity of tropical cyclones, both radii have larger medians over the WNP than over the SCS. The correlations of annual mean tropical cyclone size parameters between over the WNP and over the SCS are not significant. At the same time, the asymmetric radii of tropical cyclones over the WNP are different from those over the SCS.展开更多
文摘骨髓增生异常肿瘤(myelodysplastic neoplasms,MDS)患者的预后与其细胞遗传学和分子遗传学特征密切相关,TP53基因作为MDS最常见的突变基因之一,其异常是MDS独立的不良预后因素以及向急性髓系白血病(acute myeloid leuke⁃mia,AML)转化的危险因素之一。新近更新的第5版世界卫生组织血液淋巴肿瘤分类标准(the 5th edition of the who classifica⁃tion of haematolymphoid tumours,WHO 2022)以及髓系肿瘤和急性白血病的国际共识分类(international consensus classification of myeloid neoplasms and acute leukemia,ICC)将伴有TP53双等位基因失活(biallelic TP53 inactivation,biTP53)的MDS作为独立的亚型列出,该亚型患者预后极差,生存期极短。目前针对伴TP53基因异常的MDS患者的治疗尚未能有效改善该类患者预后,新型靶向药物、免疫治疗等均在探索中,本文就国内外对伴TP53基因异常的MDS的临床研究进展进行综述。
基金supported in part by the National Natural Science Foundation of China under contract Nos 40675013 and 40906010the China Meteorological Administration project for popularizing new techniques under contract No.CMATG2007M23+1 种基金the scientific and technological planning project from Guangdong Province under contract No.2006B37202005The work of Wang Xin is supported by City University of Hong Kong Research Scholarship Enhancement Scheme and the City University of Hong Kong Strategic Research Grants 7002329
文摘Using the observations from ICOADS datasets and contemporaneous NCEP/NCAR reanalysis datasets during 1960-2002,the study classifies the airflows in favor of sea fog over the Huanghai （Yellow） Sea in boreal spring （April-May） with the method of trajectory analysis,and analyzes the changes of proportions of warm and cold sea fogs along different paths of airflow.According to the heat balance equation,we investigate the relationships between the marine meteorological conditions and the proportion of warm and cold sea fog along different airflow paths.The major results are summarized as follows.（1） Sea fogs over the Huanghai Sea in spring are not only warm fog but also cold fog.The proportion of warm fog only accounts for 44% in April,while increases as high as 57% in May.（2） Four primary airflow paths leading to spring sea fog are identified.They are originated from the northwest,east,southeast and southwest of the Huanghai Sea,respectively.The occurrence ratios of the warm sea fog along the east and southeast airflow paths are high of 55% and 70%,while these along the southwest and northwest airflow paths are merely 17.9% and 50%.（3） The key physical processes governing the warm/cold sea fog are heat advection transport,longwave radiation cooling at fog top,solar shortwave warming and latent heat flux between airsea interfaces.（4） The characteristics of sea fog along the four airflow paths relate closely to the conditions of water vapor advection,and the vertical distribution of relative humidity.
文摘The best track dataset of tropical cyclones in the western North Pacific （WNP） and the South China Sea （SCS） from 1977 to 2005 during the satellite era, the NCEP/NCAR reanalysis dataset and the extended reconstructed sea surface temperature dataset are employed in this study. The main climatological characteristics of tropical cyclone formation over the WNP and the SCS are compared. It is found that there is obviously different for the locations of tropical cyclone origins, achieving the lowest central pressure and termination points between over the WNP and over the SCS. The annual number of tropical cyclones forming over the SCS is obviously less than over the WNP, and there is a significant negative correlation with the correlation coefficient being - 0.36 at the 5% significance level between over the WNP and over the SCS. The mean speed of tropical cyclone moving is 6.5 m/s over the WNP and 4.6 m/s over the SCS. The mean lowest central pressure of tropical cyclones is obviously weaker over the SCS than over the WNP. The tropical cyclone days per year, mean total distance and total displacement of tropical cyclone traveled over the WNP are all obviously longer than those over the SCS. Tropical cyclone may intensify to Saffir - Simpson hurricane scale 5 over the WNP, but no tropical cyclone can intensify to Saffir - Simpson hurricane scale 3 over the SCS. The changing ranges of the radii （R15,R16） of the 15.4 m/s winds them and the 25.7 m/s winds over the WNP are obviously wider than those over the SCS, and the median values of the radii over the WNP are also larger than those over the SCS. For the same intensity of tropical cyclones, both radii have larger medians over the WNP than over the SCS. The correlations of annual mean tropical cyclone size parameters between over the WNP and over the SCS are not significant. At the same time, the asymmetric radii of tropical cyclones over the WNP are different from those over the SCS.
