为探究低聚果糖(fructooligosaccharides,FOS)对C57BL/6小鼠肥胖预防及其肠道菌群的调节作用,将50只雄性5周龄C57BL/6小鼠随机分为5组,正常组食用正常饲料,其他组通过食用高脂饲料构建肥胖模型,正常组、模型组灌胃给予生理盐水,实验组...为探究低聚果糖(fructooligosaccharides,FOS)对C57BL/6小鼠肥胖预防及其肠道菌群的调节作用,将50只雄性5周龄C57BL/6小鼠随机分为5组,正常组食用正常饲料,其他组通过食用高脂饲料构建肥胖模型,正常组、模型组灌胃给予生理盐水,实验组灌胃给予高、低剂量的FOS,阳性对照组灌胃给予奥利司他,实验进行6周。采用高通量16S rRNA基因扩增测序、酶联免疫吸附测试等方法,分析FOS对C57BL/6小鼠的肥胖预防及肠道菌群的调节作用。结果表明,高、低剂量FOS都显著降低了肥胖模型小鼠的Lee’s指数、附睾脂肪指数(P<0.05),并显著升高了肥胖模型小鼠血清高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)浓度(P<0.05);高剂量FOS显著降低了肥胖模型小鼠的体质量增量及血清低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、脂多糖(lipopolysaccharide,LPS)水平(P<0.05)。在肠道菌群方面,与正常组相比,模型组小鼠的厚壁菌门(Firmicutes)相对丰度显著升高(P<0.05),拟杆菌门(Bacteroidota)相对丰度显著降低(P<0.05)。FOS干预组小鼠肠道菌群得到一定恢复,菌群组成与正常组趋近。综上,FOS可控制小鼠肥胖,改善其肠道菌群。展开更多
A new ternary compound La8Al13Sn3 was synthesized and studied by means of X-ray powder diffraction technique. The compound La8Al13Sn3 crystallizes in a hexagonal AlB2-type structure with space group P6/mmm （No. 191）...A new ternary compound La8Al13Sn3 was synthesized and studied by means of X-ray powder diffraction technique. The compound La8Al13Sn3 crystallizes in a hexagonal AlB2-type structure with space group P6/mmm （No. 191） and the lattice parameters a = 0.44919（1） nm and c = 0.43835（1） nm. The Smith and Snyder figure of merit for index, FN, is F30 = 197.3（30）. The Rietveld refinement for the crystal structure of the compound was carried out successfully. The liability R-factors of Rietveld refinement are Rp = 0.114 and Rwp = 0.148. The compound La8Al13Sn3 decomposes into LaAl2 with cubic structure and space group Fd 3m （227）, LaAl3 with hexagonal structure and space group P63/mmc （194）, and Sn at 720°C.展开更多
文摘为探究低聚果糖(fructooligosaccharides,FOS)对C57BL/6小鼠肥胖预防及其肠道菌群的调节作用,将50只雄性5周龄C57BL/6小鼠随机分为5组,正常组食用正常饲料,其他组通过食用高脂饲料构建肥胖模型,正常组、模型组灌胃给予生理盐水,实验组灌胃给予高、低剂量的FOS,阳性对照组灌胃给予奥利司他,实验进行6周。采用高通量16S rRNA基因扩增测序、酶联免疫吸附测试等方法,分析FOS对C57BL/6小鼠的肥胖预防及肠道菌群的调节作用。结果表明,高、低剂量FOS都显著降低了肥胖模型小鼠的Lee’s指数、附睾脂肪指数(P<0.05),并显著升高了肥胖模型小鼠血清高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)浓度(P<0.05);高剂量FOS显著降低了肥胖模型小鼠的体质量增量及血清低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、脂多糖(lipopolysaccharide,LPS)水平(P<0.05)。在肠道菌群方面,与正常组相比,模型组小鼠的厚壁菌门(Firmicutes)相对丰度显著升高(P<0.05),拟杆菌门(Bacteroidota)相对丰度显著降低(P<0.05)。FOS干预组小鼠肠道菌群得到一定恢复,菌群组成与正常组趋近。综上,FOS可控制小鼠肥胖,改善其肠道菌群。
基金supported by the Natural Sci-ence Foundation of Guangxi Province, China (Nos. 0832027 and 0640072)
文摘A new ternary compound La8Al13Sn3 was synthesized and studied by means of X-ray powder diffraction technique. The compound La8Al13Sn3 crystallizes in a hexagonal AlB2-type structure with space group P6/mmm （No. 191） and the lattice parameters a = 0.44919（1） nm and c = 0.43835（1） nm. The Smith and Snyder figure of merit for index, FN, is F30 = 197.3（30）. The Rietveld refinement for the crystal structure of the compound was carried out successfully. The liability R-factors of Rietveld refinement are Rp = 0.114 and Rwp = 0.148. The compound La8Al13Sn3 decomposes into LaAl2 with cubic structure and space group Fd 3m （227）, LaAl3 with hexagonal structure and space group P63/mmc （194）, and Sn at 720°C.
