基于正念监控与接受理论(monitor and acceptance theory,MAT),以460名专业运动员为被试,探究特质正念与专业运动员心理健康的关系。结果发现:(1)特质正念正向预测主观幸福感,负向预测抑郁-焦虑-压力,并分别通过基本心理需要满足、自我...基于正念监控与接受理论(monitor and acceptance theory,MAT),以460名专业运动员为被试,探究特质正念与专业运动员心理健康的关系。结果发现:(1)特质正念正向预测主观幸福感,负向预测抑郁-焦虑-压力,并分别通过基本心理需要满足、自我同情的单独中介及两者的链式中介发挥作用;(2)该模型存在显著的性别差异,以主观幸福感为结果变量时,男性组中介效应大于女性组;以抑郁-焦虑-压力为结果变量时,女性组中介效应大于男性组。研究结果可以为提升专业运动员心理健康提供理论依据和干预方向。展开更多
目的探讨改良颅内外血管搭桥术治疗缺血性脑血管病的经验及效果。方法回顾性分析改良颅内外血管搭桥术治疗64例缺血性脑血管病病人的临床资料,其中行双侧血管搭桥术4例,额与顶支双支吻合3例,顶支吻合21例,额支吻合36例。采用CT灌注成像(...目的探讨改良颅内外血管搭桥术治疗缺血性脑血管病的经验及效果。方法回顾性分析改良颅内外血管搭桥术治疗64例缺血性脑血管病病人的临床资料,其中行双侧血管搭桥术4例,额与顶支双支吻合3例,顶支吻合21例,额支吻合36例。采用CT灌注成像(CT perfusion,CTP)评价术后血流灌注情况,改良Rankin量表(modified Rankin scale,mRS)评估病人预后。结果术后出现硬膜下血肿2例,高灌注综合征38例。术后6周CTA显示术侧颅内外搭桥血管通畅;CTP显示:局部脑血流量(regional cerebral blood flow,CBF)较术前明显改善(P<0.001),局部血流达峰时间(regional time to peak,TTP)和局部平均通过时间(regional mean transit time,MTT)明显降低(P<0.05)。60例随访1年,CTA显示吻合口变窄2例,手术前后mRS评分经统计学分析发现:G=-0.374、P<0.001,提示:随着时间的延长,病人神经功能逐步改善。结论改良颅内外血管搭桥术可明显提高术侧脑血流量,改善脑缺血症状,是脑血流动力学障碍性脑缺血较好的手术方式。展开更多
Salinity is a crucial environmental stress that severely affects fish growth and survival.Under environmental stress,DNA methylation plays an important role in gene expression and genome function.To better understand ...Salinity is a crucial environmental stress that severely affects fish growth and survival.Under environmental stress,DNA methylation plays an important role in gene expression and genome function.To better understand the epigenetic regulation mechanism of igf2 under low salinity stress,we analyzed the DNA methylation at 5’UTR,exon1,intron1,and exon2,and analyzed the relationship of DNA methylation with mRNA abundance as well as the special single CpG sites methylation patterns of igf2 in the liver of half smooth tongue sole under low salinity(15)for 0,7,and 60 d.When exposed to low salinity,DNA methylation at 5’UTR and exon2 remained stable,while it was up-regulated firstly and then down-regulated at exon1 and intron1.Some single CpG sites of igf2 associated with low salinity,and most of these sites with significantly changed methylation levels(P<0.05)are located in intron1 area.The discrepant variation of single CpG sites methylation levels and igf2 expression further revealed that females and males showed different response to low salinity.Remarkably,the 38-CpG site of intron1 servers as a sexual marker.Additionally,our integrative analysis demonstrated that regional DNA of igf2 methylation had highly complex interplay on gene expression.The single CpG sites in intron1 were indispensable epigenetic markers under external environmental stress.Above all,to resist the low salinity stress,half smooth tongue sole liver can regulate the expression of igf2 through methylation of CpG sites in intron1.展开更多
文摘基于正念监控与接受理论(monitor and acceptance theory,MAT),以460名专业运动员为被试,探究特质正念与专业运动员心理健康的关系。结果发现:(1)特质正念正向预测主观幸福感,负向预测抑郁-焦虑-压力,并分别通过基本心理需要满足、自我同情的单独中介及两者的链式中介发挥作用;(2)该模型存在显著的性别差异,以主观幸福感为结果变量时,男性组中介效应大于女性组;以抑郁-焦虑-压力为结果变量时,女性组中介效应大于男性组。研究结果可以为提升专业运动员心理健康提供理论依据和干预方向。
文摘目的探讨改良颅内外血管搭桥术治疗缺血性脑血管病的经验及效果。方法回顾性分析改良颅内外血管搭桥术治疗64例缺血性脑血管病病人的临床资料,其中行双侧血管搭桥术4例,额与顶支双支吻合3例,顶支吻合21例,额支吻合36例。采用CT灌注成像(CT perfusion,CTP)评价术后血流灌注情况,改良Rankin量表(modified Rankin scale,mRS)评估病人预后。结果术后出现硬膜下血肿2例,高灌注综合征38例。术后6周CTA显示术侧颅内外搭桥血管通畅;CTP显示:局部脑血流量(regional cerebral blood flow,CBF)较术前明显改善(P<0.001),局部血流达峰时间(regional time to peak,TTP)和局部平均通过时间(regional mean transit time,MTT)明显降低(P<0.05)。60例随访1年,CTA显示吻合口变窄2例,手术前后mRS评分经统计学分析发现:G=-0.374、P<0.001,提示:随着时间的延长,病人神经功能逐步改善。结论改良颅内外血管搭桥术可明显提高术侧脑血流量,改善脑缺血症状,是脑血流动力学障碍性脑缺血较好的手术方式。
基金supported by the Key Laboratory of Mariculture of Ministry of Education, Ocean University of China (No. KLM2018009)the National Natural Science Foundation of China (No. 31672642)
文摘Salinity is a crucial environmental stress that severely affects fish growth and survival.Under environmental stress,DNA methylation plays an important role in gene expression and genome function.To better understand the epigenetic regulation mechanism of igf2 under low salinity stress,we analyzed the DNA methylation at 5’UTR,exon1,intron1,and exon2,and analyzed the relationship of DNA methylation with mRNA abundance as well as the special single CpG sites methylation patterns of igf2 in the liver of half smooth tongue sole under low salinity(15)for 0,7,and 60 d.When exposed to low salinity,DNA methylation at 5’UTR and exon2 remained stable,while it was up-regulated firstly and then down-regulated at exon1 and intron1.Some single CpG sites of igf2 associated with low salinity,and most of these sites with significantly changed methylation levels(P<0.05)are located in intron1 area.The discrepant variation of single CpG sites methylation levels and igf2 expression further revealed that females and males showed different response to low salinity.Remarkably,the 38-CpG site of intron1 servers as a sexual marker.Additionally,our integrative analysis demonstrated that regional DNA of igf2 methylation had highly complex interplay on gene expression.The single CpG sites in intron1 were indispensable epigenetic markers under external environmental stress.Above all,to resist the low salinity stress,half smooth tongue sole liver can regulate the expression of igf2 through methylation of CpG sites in intron1.
