油箱壳外形复杂,拉深成形过程中容易出现侧壁起皱和圆角处破裂的缺陷,成形工艺参数的确定非常重要.结合分类与回归决策树（classification and regression tree,CART）的人工智能技术和模型交叉验证方法,通过调用Python平台开源库Scikit...油箱壳外形复杂,拉深成形过程中容易出现侧壁起皱和圆角处破裂的缺陷,成形工艺参数的确定非常重要.结合分类与回归决策树（classification and regression tree,CART）的人工智能技术和模型交叉验证方法,通过调用Python平台开源库Scikit-Learn对油箱壳拉深成形数值模拟结果进行知识挖掘,筛选出对油箱壳拉深成形影响大的工艺参数;以基尼指数（Gini index）最小化作为最优特征值及最优切分点选择的依据,构建了工艺参数与性能指标关系的CART决策树,提取出了可靠的工艺设计规则.油箱壳拉深实例表明,CART决策树理论的知识发现技术是实现板料成形过程数值模拟结果潜在知识挖掘的可行途径.展开更多
AIM: To establish and apply a new LC/MS/MS method for the simultaneous, quantitative determination of six ingredients, aucubin(AU), geniposide(GP), geniposidic acid(GPA), pinoresinol diglucoside(PDG), secologanin(SLG)...AIM: To establish and apply a new LC/MS/MS method for the simultaneous, quantitative determination of six ingredients, aucubin(AU), geniposide(GP), geniposidic acid(GPA), pinoresinol diglucoside(PDG), secologanin(SLG), and loganin(LG) in single and combined extracts of Eucommia ulmoides and Dipsacus asperoides. METHOD: Using the LC/MS/MS-ESI--MRM mode to detect the six compounds, chromatographic separation was achieved on an Agilent Eclipse plus C18 column, and the mobile phase consisted of solvent A(CH3CN) and solvent B(H2O containing 0.01% CH3 COOH V/V). RESULTS: This method was successfully applied to quantify the six compounds in rat plasma after oral administration, and showed good precision, accuracy, reproducibility, and linear regression(r2 >0.99). CONCLUSION: The results showed that following the use of the two medicinal plants, for AU and GP, the values of tmax markedly increased, and the values of cmax markedly decreased. It was found that the compatibility of the medicinal plants might affect their pharmacokinetic properties of their constituents.展开更多
文摘油箱壳外形复杂,拉深成形过程中容易出现侧壁起皱和圆角处破裂的缺陷,成形工艺参数的确定非常重要.结合分类与回归决策树（classification and regression tree,CART）的人工智能技术和模型交叉验证方法,通过调用Python平台开源库Scikit-Learn对油箱壳拉深成形数值模拟结果进行知识挖掘,筛选出对油箱壳拉深成形影响大的工艺参数;以基尼指数（Gini index）最小化作为最优特征值及最优切分点选择的依据,构建了工艺参数与性能指标关系的CART决策树,提取出了可靠的工艺设计规则.油箱壳拉深实例表明,CART决策树理论的知识发现技术是实现板料成形过程数值模拟结果潜在知识挖掘的可行途径.
基金supported by the Program for Important Drug Development of MOST,China(2012ZX 09304007)the Important Drug Development of MOST,China(2013ZX09401-004-002)+1 种基金the Tianjin Committee of Science and Technology,China(10SYSYJC28900)Natural Science Foundation of China(NSFC81125024)
文摘AIM: To establish and apply a new LC/MS/MS method for the simultaneous, quantitative determination of six ingredients, aucubin(AU), geniposide(GP), geniposidic acid(GPA), pinoresinol diglucoside(PDG), secologanin(SLG), and loganin(LG) in single and combined extracts of Eucommia ulmoides and Dipsacus asperoides. METHOD: Using the LC/MS/MS-ESI--MRM mode to detect the six compounds, chromatographic separation was achieved on an Agilent Eclipse plus C18 column, and the mobile phase consisted of solvent A(CH3CN) and solvent B(H2O containing 0.01% CH3 COOH V/V). RESULTS: This method was successfully applied to quantify the six compounds in rat plasma after oral administration, and showed good precision, accuracy, reproducibility, and linear regression(r2 >0.99). CONCLUSION: The results showed that following the use of the two medicinal plants, for AU and GP, the values of tmax markedly increased, and the values of cmax markedly decreased. It was found that the compatibility of the medicinal plants might affect their pharmacokinetic properties of their constituents.
