Magnetic proximity effect in the two-dimensional ε-Fe_(2)O_(3)/NbSe_(2)heterojunction

Two-dimensional(2D)magnet/superconductor heterostructures can promote the design of artificial materials for exploring 2D physics and device applications by exotic proximity effects.However,plagued by the low Curie temperature and instability in air,it is hard to realize practical applications for the reported layered magnetic materials at present.In this paper,we developed a space-confined chemical vapor deposition method to synthesize ultrathin air-stable ε-Fe_(2)O_(3) nanosheets with Curie temperature above 350 K.The ε-Fe_(2)O_(3)/NbSe_(2) heterojunction was constructed to study the magnetic proximity effect on the superconductivity of the NbSe_(2) multilayer.The electrical transport results show that the subtle proximity effect can modulate the interfacial spin–orbit interaction while undegrading the superconducting critical parameters.Our work paves the way to construct 2D heterojunctions with ultrathin nonlayered materials and layered van der Waals(vdW)materials for exploring new physical phenomena.

Study on improving hematopoietic function of rats with blood deficiency syndrome by Shengxuebao mixture

Background:Shengxuebao mixture(SXBM)is a novel herbal drug approved by China State Food and Drug Administration for the treatment of Leukopenia and iron deficiency anemia caused by radiotherapy and chemotherapy.Methods:To explore the mechanism of SXBM in treating blood deficiency syndrome(BDS).Firstly,network pharmacology and in vivo experiments were used to screen candidate targets and important signaling pathways of SXBM,GO functional enrichment and KEGG pathway analysis were performed.Secondly,a BDS rat model was established to verify the results of the analysis of network pharmacological enrichment.Histopathology and routine peripheral blood examination were observed.The expressions of tumor necrosis factor-α,interleukin(IL)-6,HIF-1αand NF-κB were detected by Western blot,and the expressions of IL-6,IL-1βwere detected by ELISA.Results:62 bioactive components,66 potential targets and 131 signaling pathways of BDS were successfully identified by network pharmacology.Molecular docking simulation techniques showed that key targets tumor necrosis factor-α,IL-6,IL-1βcan dock well with crucial components,and the BDS-related signaling pathways HIF-1 and JAK-STAT play a vital role.The combined model experiment of acetylphenylhydrazine and cyclophosphamide showed that the model group had obvious blood deficiency,and the histopathology and blood routine were effectively restored after administration.Our findings indicate that SXBM’s therapeutic effect on BDS primarily involves the mediation of the HIF-1α/NF-κB signaling pathway and the regulation of hematopoietic factor expression.Conclusion:This study not only affirmed the protective properties of SXBM against BDS but also provided insights into a potential mechanism for blood replenishment in the treatment of BDS using SXBM.

参苓白术散治疗老年男性肌少症的成本-效用分析

目的评价参苓白术散治疗老年男性肌少症的成本-效用。方法280例老年男性肌少症患者随机分为干预组和对照组各140例,两组患者均给予营养运动治疗,干预组在营养运动治疗基础上加用参苓白术散,两组患者均随访24周。从卫生体系角度出发,利用TreeAge Pro 2011软件建立决策树模型,对两种治疗方案进行成本-效用分析,并采用敏感性分析对结果的不确定性进行评价。结果与对照组相比,干预组方案成本(5019.46元vs.4864.57元)、效用[0.90357质量调整生命年(QALYs)vs.0.89430 QALYs]均较高,增量成本-效用比为16712.05元/QALY,低于意愿支付阈值。敏感性分析结果与成本-效用分析结果一致。结论与单独应用营养运动治疗相比,老年男性肌少症患者应用参苓白术散联合营养运动治疗更具有成本-效用。

Development of multi-group Monte-Carlo transport and depletion coupling calculation method and verification with metal-fueled fast reactor

The accurate modeling of depletion,intricately tied to the solution of the neutron transport equation,is crucial for the design,analysis,and licensing of nuclear reactors and their fuel cycles.This paper introduces a novel multi-group Monte-Carlo depletion calculation approach.Multi-group cross-sections(MGXS)are derived from both 3D whole-core model and 2D fuel subassembly model using the continuous-energy Monte-Carlo method.Core calculations employ the multi-group Monte-Carlo method,accommodating both homogeneous and specific local heterogeneous geometries.The proposed method has been validated against the MET-1000 metal-fueled fast reactors,using both the OECD/NEA benchmark and a new refueling benchmark introduced in this paper.Our findings suggest that microscopic MGXS,produced via the Monte-Carlo method,are viable for fast reactor depletion analyses.Furthermore,the locally heterogeneous model with angular-dependent MGXS offers robust predictions for core reactivity,control rod value,sodium void value,Doppler constants,power distribution,and concentration levels.

Verification of neutron-induced fission product yields evaluated by a tensor decompsition model in transport-burnup simulations

Neutron-induced fission is an important research object in basic science.Moreover,its product yield data are an indispensable nuclear data basis in nuclear engineering and technology.The fission yield tensor decomposition(FYTD)model has been developed and used to evaluate the independent fission product yield.In general,fission yield data are verified by the direct comparison of experimental and evaluated data.However,such direct comparison cannot reflect the impact of the evaluated data on application scenarios,such as reactor transport-burnup simulation.Therefore,this study applies the evaluated fission yield data in transport-burnup simulation to verify their accuracy and possibility of application.Herein,the evaluated yield data of235U and239Pu are applied in the transport-burnup simulation of a pressurized water reactor(PWR)and sodium-cooled fast reactor(SFR)for verification.During the reactor operation stage,the errors in pin-cell reactivity caused by the evaluated fission yield do not exceed 500 and 200 pcm for the PWR and SFR,respectively.The errors in decay heat and135Xe and149Sm concentrations during the short-term shutdown of the PWR are all less than 1%;the errors in decay heat and activity of the spent fuel of the PWR and SFR during the temporary storage stage are all less than 2%.For the PWR,the errors in important nuclide concentrations in spent fuel,such as90Sr,137Cs,85Kr,and99Tc,are all less than 6%,and a larger error of 37%is observed on129I.For the SFR,the concentration errors of ten important nuclides in spent fuel are all less than 16%.A comparison of various aspects reveals that the transport-burnup simulation results using the FYTD model evaluation have little difference compared with the reference results using ENDF/B-Ⅷ.0 data.This proves that the evaluation of the FYTD model may have application value in reactor physical analysis.

Ginsenoside Rb1 improves energy metabolism after spinal cord injury

Mitochondrial damage caused by oxidative stress and energy deficiency induced by focal ischemia and hypoxia are important factors that aggravate diseases.Studies have shown that ginsenoside Rb1 has neurotrophic and neuroprotective effects.However,whether it influences energy metabolism after spinal cord injury remains unclear.In this study,we treated mouse and cell models of spinal cord injury with ginsenoside Rb1.We found that ginsenoside Rb1 remarkably inhibited neuronal oxidative stress,protected mitochondria,promoted neuronal metabolic reprogramming,increased glycolytic activity and ATP production,and promoted the survival of motor neurons in the anterior horn and the recovery of motor function in the hind limb.Because sirtuin 3 regulates glycolysis and oxidative stress,mouse and cell models of spinal cord injury were treated with the sirtuin 3 inhibitor 3-TYP.When Sirt3 expression was suppressed,we found that the therapeutic effects of ginsenoside Rb1 on spinal cord injury were remarkably inhibited.Therefore,ginsenoside Rb1 is considered a potential drug for the treatment of spinal cord injury,and its therapeutic effects are closely related to sirtuin 3.

InSe-Te van der Waals heterostructures for current rectification and photodetection

As the basis of modern electronics and optoelectronics,high-performance,multi-functional p-n junctions have manifested and occupied an important position.However,the performance of the silicon-based p-n junctions declines gradually as the thickness approaches to few nanometers.The heterojunction constructed by two-dimensional(2D)materials can significantly improve the device performance compared with traditional technologies.Here,we report the In Se-Te type-II van der Waals heterostructures with rectification ratio up to 1.56×10^(7) at drain-source voltage of±2 V.The p-n junction exhibits a photovoltaic and photoelectric effect under different laser wavelengths and densities and has high photoresponsivity and detectivity under low irradiated light power.Moreover,the heterojunction has stable photo/dark current states and good photoelectric switching characteristics.Such high-performance heterostructured device based on 2D materials provides a new way for futural electronic and optoelectronic devices.

OsNPF3.1,a member of the NRT1/PTR family,increases nitrogen use efficiency and biomass production in rice

The overuse of nitrogen(N)fertilizer in fields has increased production costs and raised environmental concerns.Increasing the N use efficiency(NUE)of rice varieties is crucial for sustainable agriculture.Here we report the cloning and characterization of OsNPF3.1,a gene that controls rice NUE.An amino acid mutation in the OsNPF3.1 coding region caused different NUEs in wild and cultivated rice.OsNPF3.1,which is expressed mainly in the aerial parts of rice,also affects rice plant height,heading date,and thousand-grain weight.The OsNPF3.1 protein is located in the plasma membrane.When OsNPF3.1 was subjected to artificial selection,two naturally varying loci were associated with NUE,of which OsNPF3.1Chr6_8741040differed between indica and japonica rice.OsNPF3.1 can be used as a new target gene for breeding rice varieties with high NUE.

Intercalation of hafnium oxide between epitaxially-grown monolayer graphene and Ir(111)substrate

Intercalation of insulating materials between epitaxial graphene and the metal substrates is highly demanded to restore the intrinsic properties of graphene,and thus essential for the graphene-based devices.Here we demonstrate a successful solution for the intercalation of hafnium oxide into the interface between full-layer graphene and Ir(111)substrate.We first intercalate hafnium atoms beneath the epitaxial graphene.The intercalation of the hafnium atoms leads to the variation of the graphene moire superstructure periodicity,which is characterized by low-energy electron diffraction(LEED)and lowtemperature scanning tunneling microscopy(LT-STM).Subsequently,we introduce oxygen into the interface,resulting in oxidization of the intercalated hafnium.STM and Raman's characterizations reveal that the intercalated hafnium oxide layer could effectively decouple the graphene from the metallic substrate,while the graphene maintains its high quality.Our work suggests a high-k dielectric layer has been successfully intercalated between high-quality epitaxial graphene and metal substrate,providing a platform for applications of large-scale,high-quality graphene for electronic devices.

Fabrication of honeycomb AuTe monolayer with Dirac nodal line fermions

Two-dimensional honeycomb lattices show great potential in the realization of Dirac nodal line fermions(DNLFs).Here,we successfully synthesized a gold telluride(AuTe)monolayer by direct tellurizing an Au(111)substrate.Low energy electron diffraction measurements reveal that it is(2×2)AuTe layer stacked onto(3×3)Au(111)substrate.Moreover,scanning tunneling microscopy images show that the AuTe layer has a honeycomb structure.Scanning transmission electron microscopy reveals that it is a single-atom layer.In addition,first-principles calculations demonstrate that the honeycomb AuTe monolayer exhibits Dirac nodal line features protected by mirror symmetry,which is validated by angle-resolved photoemission spectra.Our results establish that monolayer AuTe can be a good candidate to investigate 2D DNLFs and provides opportunities to realize high-speed low-dissipation devices.

Transcriptome analysis reveals potential genes associated with plant height in rice

Plant height(PH)is a complex trait regulated by the environment and multiple genes.PH directly affects crop yield,harvest index,and lodging resistance.From plant dwarf mutants,many genes related to PH have been identified and described.Nonetheless,the molecular mechanism of height regulation in high-culm rice mutants has not been well studied.By using transcriptome and weighted gene co-expression network analysis(WGCNA),we identified the differentially expressed genes(DEGs)between high-culm rice mutants(MUT)and wild-type(WT)and explored the key pathways and potential candidate genes involved in PH regulation.Transcriptome analysis identified a total of 2,184 DEGs,of which 1,317 were identified at the jointing stage and 1,512 were identified at the heading stage.Kyoto Encyclopedia of Genes and Genomes enrichment showed that the enrichment pathways were mainly involved in plant hormone signal transduction,ABC transportation,and steroid hormone biosynthesis.Among these metabolic pathways,LOC_Os05g43910 and LOC_Os01g35030 were auxin(IAA)-related genes,up-regulated in MUT and LOC_Os02g08500(LEPTO1),LOC_Os11g04720,and LOC_Os12g04500 were cytokinin(CK)-related genes,downregulated in MUT.The WGCNA identified four modules(light cyan,dark grey,grey,and pale turquoise)closely related to PH,and seven key genes were screened from these modules,of which two were up-regulated cell wallrelated genes(LOC_Os01g26174(OsWAK5),LOC_Os06g05050)in MUT,and one gibberellic acid(GA)gene(LOC_Os06g37364,OsKO2)was also up-regulated.These genes might be closely related to PH regulation.These findings help us better understand the transcriptional regulation of rice plant growth and development and provide a theoretical basis for mapping and cloning the PH regulatory genes.

Epithelioid trophoblastic tumor of the lower uterine segment and cervical canal:A case report

BACKGROUND Epithelioid trophoblastic tumor(ETT) is the rarest type of gestational trophoblastic tumor(GTT). It has been reported that more than 50% of ETTs arise in the uterine cervix or the lower uterine segment. Here, we report a case of ETT within the lower uterine segment and cervical canal and discuss its manifestations,possible causes, and related influencing factors.CASE SUMMARY A 35-year-old woman(gravida 7, miscarriage 3, induction 2 with 1 being twins,para 2 of cesarean section, live 2), who had amenorrhea for 9 mo after breastfeeding for 22 mo after the last cesarean section, was diagnosed with ETT. The lesion was present in the lower uterine segment and endocervical canal with severe involvement of the anterior wall of the lower uterine segment and the front wall of the lower uterine segment where the cesarean incisions were made.Laboratory tests showed slight elevation of serum beta-human chorionic gonadotropin. Intraoperative exploration showed the presence of a normal-sized uterus body with an enlarged tumor in the lower uterine segment. The surface of the lower uterine segment was light blue, the entire lesion was approximately about 8cm × 8 cm × 9 cm, with compression and displacement of the surrounding tissue.Histological examination diagnosed ETT. Immunohistochemical analysis showed positive expression of p63, with a Ki-67 proliferation index of 40%.CONCLUSION A search of the PubMed database using the search terms "cesarean section" and "epithelioid trophoblastic tumor" retrieved nine articles, including 13 cases of ETT and ETT-related lesions, all 13 cases had a history of cesarean section, and the lesions were all located at the cesarean section incision on the anterior wall of the lower uterine segment. The present case is the 14th reported case of ETT after cesarean section. Therefore, we deduced that cesarean section trauma had an important effect on the occurrence of ETT at this site.

Enhanced phase sensitive amplification towards improving noise immunity

Quantum states are essential resource for quantum-enhanced applications.Loss incurred in the distribution channel,however,dissipates the high signal-to-noise ratio advantage enjoyed by the squeezed state.Here,we first demonstrate noise immunity enhancement by using phase-sensitive amplifier(PSA)with measurement-based noiseless linear amplifier(MB-NLA).We explore the signal transfer capability with the amplifier in a noisy channel.The MB-NLA enhanced PSA has obvious suppression effect on channel noises,especially it has improvement for the noise contaminated signal.Better performance can be achieved by flexibly adjusting amplifier parameters.With the amplifier,it is promising to overcome the entanglement-distribution loss and show its superiority in squeezing based quantum sensing.

Delayed diagnosis of abdominal Henoch-Schonlein purpura in children:A case report

BACKGROUND For children with abdominal Henoch-Schonlein purpura presenting abdominal pain as an initial symptom and severe clinical manifestations,but without purpura appearance on the skin,the diagnosis and treatment are relatively difficult.This study summarized the characteristics of this group of patients by literature review and provided additional references for further refinement of glucocorticoid therapy in this vasculitis.CASE SUMMARY A 6-year-old girl presented mainly with repeated abdominal pain and had received short-term out-of-hospital treatment with hydrocortisone.On day 7 after onset,gastroscopy revealed chronic non-atrophic gastritis and erosive duodenitis without purpuric rash,and no obvious resolution of the abdominal pain was found after treatment against infection and for protection of gastric mucosa.On day 14 the inflammatory indices continued to rise and the pain was relieved after enhanced anti-infective therapy,but without complete resolution.On day 19,the patient presented with aggravated abdominal pain with purplish-red dots on the lower limbs,by which Henoch-Schonlein purpura was confirmed.After 5 d of sequential treatment with methylprednisolone and prednisone,abdominal pain disappeared and she was discharged.CONCLUSION Henoch-Schonlein purpura-related rash may appear after long-term abdominal pain,and should be distinguished from acute and chronic gastrointestinal diseases at the early stage without typical rash.For bacterial infection-induced Henoch-Schonlein purpura,glucocorticoid therapy alone without clearing the infection may not relieve symptoms.

Introduction to the Special Issue on Passive and Active Noise Control for Vehicle

The new generation of road vehicles is undergoing rapid advancements towards electrification,intelligence,inter-connection and sharing.Besides being a means of transportation,vehicles are expected to have more functions,such as work and entertainment.In line with these trends,vehicle interior noise control deserves renewed attention beyond traditional approaches such as just controlling physical acoustic quantities.The last decade has witnessed revolutionary progress in materials,structures,control methods and technologies that create a quieter and more comfortable interior sound environment for vehicles.However,prevalent challenges remain,notably the intense time-varying and nonlinear characteristics of interior noise generated in the running vehicle,especially under high-speed driving conditions.

α型锂辉石在混酸介质HF/H_2SO_4中浸出锂的动力学（英文）

基于单因素条件实验结果,对α型锂辉石在混酸介质HF/H_2SO_4中不同温度下的浸出动力学进行系统研究。结果表明:在矿物/HF/H_2SO_2比1 g:3 mL:2 mL、50～100°C条件下,锂的浸出过程符合缩核动力学模型,浸出速率主要由表面化学反应以及产物固膜扩散共同控制,表观活化能Ea为32.68 kJ/mol。对固相不溶渣及浸出液组成的分析结果显示:固膜的形成主要由浸出过程中不溶氟化物,如锂钠冰晶石(Na_3Li_2Al_2F_(12))、钠冰晶石(Na_3AlF_6)、氟化钙(CaF_2)、钾冰晶石(K-2AlF_5)、氟化铝(AlF_3)及少量氟硅酸盐(Na_SiF_6、KNaSiF_6)的生成所致。此外,氢氟酸添加量及浸出温度可通过影响HF分子在浸出锂、铝和硅间的分配而影响浸出过程的选择性。

Discussion on Homogenization of Emergency Clinical Decision

The objective of this work is to explore how to realize the homogenization of emergency clinical decision, and it means that patients receive the same effect of clinical decisions and the treatment in a different hospital. In order to achieve that, emergency doctors should first have the same clinical thinking and thinking mode which is the biggest challenge for homogenization of emergency clinical decision. The task of emergency medicine is to give priority to the treatment of critically ill patients, so step-down thinking of “excluding life-threatening symptoms first” is the basis, the preemptive thinking is the means, and Process thinking is the key of homogenization;The initial diagnosis and treatment mode of symptom-oriented is the starting point for emergency decision;establishing a unified “checklist” can not only broaden the lateral thinking of emergency doctors, but also unify the thinking of differential diagnosis of emergency;dynamic observation should run through the whole diagnosis and treatment process, which is necessary for the homogenization of emergency decision.

Evaluation of Prognosis of Brain Function with Early Transcranial Color Doppler Ultrasound in Patients after Cardiopulmonary Resuscitation

Objective: To evaluate the clinical value of transcranial color Doppler ultrasound (TCCD) in assessing cerebral function after cardiopulmonary resuscitation (CPR). Methods: A prospective study was conducted in 52 patients with cardiac arrest treated by CPR from January 2018 to January 2020, and its clinical data were analyzed. According to classification of cerebral performance category (CPC), 31 cases (CPC grade 1 - 2) were selected in the good prognosis group and 21 cases (CPC grade 3 - 5) in the poor prognosis group. The cerebral blood flow was measured by transcranial Doppler ultrasound (TCCD) 24 h after CPR, and the differences were compared between the two groups in stroke index, diastolic blood flow velocity (Vd), systolic peak blood flow velocity (Vs) and mean peak blood flow velocity (Vm). The ROC curve of cerebral blood flow after CPR was drawn to predict the prognosis of brain function. Results: The data showed that the pulsatility index of middle cerebral artery of the poor prognosis group decreased within 24 h;the difference between the two groups was statistically significant (p < 0.05);the Vd, Vs, Vm increased in the good prognosis group;the difference between the two groups was statistically significant (p < 0.05). The ROC curve of cerebral blood flow after CPR was drawn to predict the prognosis of brain function, and the results showed that the area under the curve and the optimal critical value of cerebral blood flow were 0.731 and 5.69. The sensitivity and specificity were 67.3% and 79.1% respectively. Conclusion: The cerebral blood flow increase in the early stage of successful CPR is positively correlated with the prognosis of cerebral functional resuscitation. Monitoring intracranial blood flow after CPR by TCCD has clinical value to evaluate prognosis of brain function.

Unveiling the Carbonation Behavior and Microstructural Changes of Magnesium Slag at 0℃

Magnesium slag(MS)is an industrial byproduct with high CO_(2)sequestration potential.This study investigates the carbonation behavior and microstructural changes of MS during wet carbonation at 0℃.XRD,TG,FTIR,SEM,and BET techniques were used to characterize the phase composition,microstructure,and porosity of MS samples carbonated for different durations.The results showed that the main carbonation products were calcite,vaterite,and highly polymerized silica gel,with particle sizes around 1μm.The low-temperature environment retarded the carbonation reaction rate and affected the morphology and crystallization of calcium carbonate.After 480 min of carbonation,the specific surface area and porosity of MS increased substantially by 740%and 144.6%,respectively,indicating improved reactivity.The microstructure of carbonated MS became denser with calcite particles surrounded by silica gel.This study demonstrates that wet carbonation of MS at 0℃significantly enhances its properties,creating an ultrafine supplementary cementitious material with considerable CO_(2)sequestration capacity.

双阴性T细胞对抗中性粒细胞胞质抗体相关性血管炎的影响

目的分析抗中性粒细胞胞质抗体相关性血管炎(AAV)患者外周血中双阴性T细胞(DNT)的表达情况。方法选取50例AAV患者(AAV组),按照疾病活动情况分为活动组36例和缓解组14例;按照有无肾损害分为肾损害组32例和非肾损害组18例。同期招募30例健康志愿者作为对照组。比较AAV组患者与对照组DNT细胞及胞内细胞因子白细胞介素17(IL-17)、白细胞介素4(IL-4)和γ干扰素(IFN-γ)水平的差异及与患者临床指标的相关性。结果AAV组患者DNT、IL-17及IFN-γ水平高于对照组(P<0.05),而IL-4低于对照组(P<0.05)。AAV患者活动组DNT、IL-17水平高于缓解组(P<0.05)。AAV患者肾损害组DNT和IL-17水平高于非肾损害组(P<0.05)。AAV患者DNT与红细胞沉降率(ESR)、血清肌酐(Scr)、24h尿蛋白、伯明翰评分、抗中性粒细胞胞质抗体滴度呈正相关(P<0.05);IL-17与Scr、24h尿蛋白呈正相关(P<0.05),而IL-4、IFN-γ与临床指标无相关性(P>0.05)。结论DNT与AAV的发病有相关性。