Lipid is a key component of plasma membrane,which plays an important role in the regulation of various cell biological behaviors,including cell proliferation,growth,differentiation and intracellular signal transductio...Lipid is a key component of plasma membrane,which plays an important role in the regulation of various cell biological behaviors,including cell proliferation,growth,differentiation and intracellular signal transduction.Studies have shown that abnormal lipid metabolism is involved in many malignant processes,including colorectal cancer(CRC).Lipid metabolism in CRC cells can be regulated not only by intracellular signals,but also by various components in the tumor microenvironment,including various cells,cytokines,DNA,RNA,and nutrients including lipids.In contrast,abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth and distal metastasis of CRC cells.In this review,we highlight the remodeling roles of lipid metabolism crosstalk between the CRC cells and the components of tumor microenvironment.展开更多
Many circular RNAs(circRNAs)are reported to be abnormally expressed during the progression of various tumors,and these circRNAs can be used as anti-tumor targets.Therefore,it is important to identify circRNAs that can...Many circular RNAs(circRNAs)are reported to be abnormally expressed during the progression of various tumors,and these circRNAs can be used as anti-tumor targets.Therefore,it is important to identify circRNAs that can be used effectively for the clinical diagnosis and treatment of colorectal cancer(CRC).Here,we report that hsa_Circ_0000826(Circ_0000826),a circ RNA with significantly reduced expression level in CRC tissues,is associated with a poor prognosis in patients.The silencing of Circ_0000826 promotes the proliferation of CRC cells.Conversely,the overexpression of Circ_0000826 restricted CRC cell proliferation both in vitro and in vivo.Furthermore,Circ_0000826 could target AU-rich element RNA-binding protein 1(AUF1).AUF1,known as heterogeneous nuclear ribonucleoprotein D(hnRNP D),could bind to the c-MYC 3’-UTR and promote c-MYC expression.When Circ_0000826 binds to AUF1,it competitively inhibits the binding of AUF1 to the c-MYC 3’-UTR,which inhibits the c-MYC expression and cell proliferation.These results provide novel insights into the functional mechanism of Circ_0000826 action in CRC progression and indicate its potential use as a therapeutic target in CRC.展开更多
基金supported by the National Natural Science Foundation of China(Nos.31800658 and 82072218)Henan Province Young and Middle-Aged Health Science and Technology Innovation Talent Project(No.YXKC2021044)+1 种基金Joint Construction Project of Henan Medical Science and Technology Research Plan(No.LHGJ20200504)Teaching and Research Cultivation Project of School of Basic Medical Sciences,Xinxiang Medical College(No.JCYXYKY202021).
文摘Lipid is a key component of plasma membrane,which plays an important role in the regulation of various cell biological behaviors,including cell proliferation,growth,differentiation and intracellular signal transduction.Studies have shown that abnormal lipid metabolism is involved in many malignant processes,including colorectal cancer(CRC).Lipid metabolism in CRC cells can be regulated not only by intracellular signals,but also by various components in the tumor microenvironment,including various cells,cytokines,DNA,RNA,and nutrients including lipids.In contrast,abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth and distal metastasis of CRC cells.In this review,we highlight the remodeling roles of lipid metabolism crosstalk between the CRC cells and the components of tumor microenvironment.
基金supported by the National Natural Science Foundation of China(Grant Nos.81802470,31800658,and U1804173)the Department of Science and Technology,Henan Province(Grant Nos.212102310621 and 192102310362)+1 种基金Joint construction project of Henan Medical Science and technology research plan(No.LHGJ20210910)the Xinxiang Medical University research funding(Grant No.XYBSKYZZ201632)。
文摘Many circular RNAs(circRNAs)are reported to be abnormally expressed during the progression of various tumors,and these circRNAs can be used as anti-tumor targets.Therefore,it is important to identify circRNAs that can be used effectively for the clinical diagnosis and treatment of colorectal cancer(CRC).Here,we report that hsa_Circ_0000826(Circ_0000826),a circ RNA with significantly reduced expression level in CRC tissues,is associated with a poor prognosis in patients.The silencing of Circ_0000826 promotes the proliferation of CRC cells.Conversely,the overexpression of Circ_0000826 restricted CRC cell proliferation both in vitro and in vivo.Furthermore,Circ_0000826 could target AU-rich element RNA-binding protein 1(AUF1).AUF1,known as heterogeneous nuclear ribonucleoprotein D(hnRNP D),could bind to the c-MYC 3’-UTR and promote c-MYC expression.When Circ_0000826 binds to AUF1,it competitively inhibits the binding of AUF1 to the c-MYC 3’-UTR,which inhibits the c-MYC expression and cell proliferation.These results provide novel insights into the functional mechanism of Circ_0000826 action in CRC progression and indicate its potential use as a therapeutic target in CRC.
