The limited potential for proliferation of human fibroblasts in culture represents cell level senescence. Aging is a programed process under generic control, and at certain stage of the life-span of animal cells, some...The limited potential for proliferation of human fibroblasts in culture represents cell level senescence. Aging is a programed process under generic control, and at certain stage of the life-span of animal cells, some genes start to express. Studying the biomarkers of senescent cells is important to understanding the basic mechanism of aging which may be relevant to the normal cell growth control and tumor biology. A protein with 72 000 Dalton molecular weight was detected by the hybridoma method in our laborotary. The protein shows specificity to senescent or presenescent cells of several cell lines, including WI-38, K.D., U2OS, etc.展开更多
文摘The limited potential for proliferation of human fibroblasts in culture represents cell level senescence. Aging is a programed process under generic control, and at certain stage of the life-span of animal cells, some genes start to express. Studying the biomarkers of senescent cells is important to understanding the basic mechanism of aging which may be relevant to the normal cell growth control and tumor biology. A protein with 72 000 Dalton molecular weight was detected by the hybridoma method in our laborotary. The protein shows specificity to senescent or presenescent cells of several cell lines, including WI-38, K.D., U2OS, etc.
