Background and Purpose-Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis. A common polymorphism in the promoter of the IL-6 gene (IL-6-1...Background and Purpose-Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis. A common polymorphism in the promoter of the IL-6 gene (IL-6-174G >C) affects plasma IL-6 concentrations and has been suggested as a risk factor for cardiovascular disease. The aim of the present case-control study was to investigate the role of this polymorphism for retinal artery occlusion (RAO). Methods-One hundred eighty-two patients with RAO and 307 control subjects were genotyped for the IL-6-174G >C polymorphism. Genotypes were determined by fluorogenic exonuclease (TaqMan) assay. Results-The prevalence of the CC genotype was signifi cantly lower in patients with RAO than in control subjects (10.4% versus 19.9% ; P=0.006). Homozygosity for the C allele was associated with an odds ratio of 0.50 (95% CI, 0.28 to 0.89) for RAO. Conclusions-The CC genotype of the IL-6-174G > C polymorphism may be associated with a protective effect against RAO.展开更多
文摘Background and Purpose-Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis. A common polymorphism in the promoter of the IL-6 gene (IL-6-174G >C) affects plasma IL-6 concentrations and has been suggested as a risk factor for cardiovascular disease. The aim of the present case-control study was to investigate the role of this polymorphism for retinal artery occlusion (RAO). Methods-One hundred eighty-two patients with RAO and 307 control subjects were genotyped for the IL-6-174G >C polymorphism. Genotypes were determined by fluorogenic exonuclease (TaqMan) assay. Results-The prevalence of the CC genotype was signifi cantly lower in patients with RAO than in control subjects (10.4% versus 19.9% ; P=0.006). Homozygosity for the C allele was associated with an odds ratio of 0.50 (95% CI, 0.28 to 0.89) for RAO. Conclusions-The CC genotype of the IL-6-174G > C polymorphism may be associated with a protective effect against RAO.
