Background. The mechanisms of the skin barrier impairment in patients with atopic dermatitis (AD) are still unknown and need further studying. Objective. We evaluated the skin of healthy subjects and of patients havin...Background. The mechanisms of the skin barrier impairment in patients with atopic dermatitis (AD) are still unknown and need further studying. Objective. We evaluated the skin of healthy subjects and of patients having atopic dermatitis with an instrument measuring electrical impedance and other noninvasive methods (transepidermal water loss, capacitance) and studied the effects of a new emollient [ProdermTM (Pro-QTM in the USA)]. Methods. After a 2-week washout period, we treated clinically noneczematous skin on the forearm of 24 patients with AD and assessed the effects with the noninvasive methods. 22 healthy subjects were used as controls. Results. The findings indicate that barrier function and hydration, and certain patterns of electrical impedance of AD skin are abnormal compared with normal skin. Moreover, there was an increase in hydration in patients’ skin after treatment and a reversal of certain impedance indices towards normal. Conclusions. Our findings demonstrate that the moisturizer we used changes some biophysical parameters when applied to atopic skin. In addition, a technique based on electrical impedance seems to give valuable information in atopic skin studies, especially the effects of moisturizers.展开更多
Objective: To assess the risk of skin cancer and other cancers among patients with atopic dermatitis. Design: Register- based retrospective cohort study. Setting: Sweden. Patients: A total of 15 666 hospitalized patie...Objective: To assess the risk of skin cancer and other cancers among patients with atopic dermatitis. Design: Register- based retrospective cohort study. Setting: Sweden. Patients: A total of 15 666 hospitalized patients identified in the national Inpatient Register as having discharge diagnoses of atopic dermatitis between January 1, 1965, and December 31, 1999. Interventions: The National Swedish Cancer Register coded malignant neoplasms during the entire period of study. Follow- up time was calculated from the date of entry in the cohort until the occurrence of a first cancer diagnosis, emigration, death, or the end of the observation period, whichever occurred first. Main Outcome Measures: Follow- up by means of record linkages to several nationwide registers, among them the National Swedish Cancer Register. Standardized incidence ratios (SIRs) (the ratios of numbers of observed patients with cancer to expected numbers of incident cases of cancer) estimated the risk of developing cancer relative to the risks in the age- , sex- , and calendar year- matched general Swedish population. Results: After excluding the first year of follow- up, the risk of developing any cancer was increased by 13% (95% confidence interval [CI] of SIR, 1.01- 1.25, based on 311 observed patients with cancer). Excess risks were observed for cancers of the esophagus (SIR, 3.5; 95% CI, 1.3- 7.7; 6 patients), pancreas (SIR, 1.9; 95% CI, 1.0- 3.4; 11 patients), brain (SIR, 1.6; 95% CI, 1.1- 2.4; 27 patients), and lung (SIR, 2.0; 95% CI, 1.3- 2.8; 31 patients) and for lymphoma (SIR, 2.0; 95% CI, 1.4- 2.9; 29 patients). There was a nonsignificant 50% excess risk for nonmelanoma skin cancer (SIR, 1.5; 95% CI, 0.8- 2.6; 12 patients), seemingly confined to men and to the first 10 years of follow- up. Malignant melanoma did not occur more often than expected. Conclusions: The observed risk elevations, all of borderline statistical significance, should be interpreted cautiously. We could not control for possible confounding by cases of cancer caused by smoking, and the combination of multiple significance testing and few observed patients may have generated chance findings.展开更多
文摘Background. The mechanisms of the skin barrier impairment in patients with atopic dermatitis (AD) are still unknown and need further studying. Objective. We evaluated the skin of healthy subjects and of patients having atopic dermatitis with an instrument measuring electrical impedance and other noninvasive methods (transepidermal water loss, capacitance) and studied the effects of a new emollient [ProdermTM (Pro-QTM in the USA)]. Methods. After a 2-week washout period, we treated clinically noneczematous skin on the forearm of 24 patients with AD and assessed the effects with the noninvasive methods. 22 healthy subjects were used as controls. Results. The findings indicate that barrier function and hydration, and certain patterns of electrical impedance of AD skin are abnormal compared with normal skin. Moreover, there was an increase in hydration in patients’ skin after treatment and a reversal of certain impedance indices towards normal. Conclusions. Our findings demonstrate that the moisturizer we used changes some biophysical parameters when applied to atopic skin. In addition, a technique based on electrical impedance seems to give valuable information in atopic skin studies, especially the effects of moisturizers.
文摘Objective: To assess the risk of skin cancer and other cancers among patients with atopic dermatitis. Design: Register- based retrospective cohort study. Setting: Sweden. Patients: A total of 15 666 hospitalized patients identified in the national Inpatient Register as having discharge diagnoses of atopic dermatitis between January 1, 1965, and December 31, 1999. Interventions: The National Swedish Cancer Register coded malignant neoplasms during the entire period of study. Follow- up time was calculated from the date of entry in the cohort until the occurrence of a first cancer diagnosis, emigration, death, or the end of the observation period, whichever occurred first. Main Outcome Measures: Follow- up by means of record linkages to several nationwide registers, among them the National Swedish Cancer Register. Standardized incidence ratios (SIRs) (the ratios of numbers of observed patients with cancer to expected numbers of incident cases of cancer) estimated the risk of developing cancer relative to the risks in the age- , sex- , and calendar year- matched general Swedish population. Results: After excluding the first year of follow- up, the risk of developing any cancer was increased by 13% (95% confidence interval [CI] of SIR, 1.01- 1.25, based on 311 observed patients with cancer). Excess risks were observed for cancers of the esophagus (SIR, 3.5; 95% CI, 1.3- 7.7; 6 patients), pancreas (SIR, 1.9; 95% CI, 1.0- 3.4; 11 patients), brain (SIR, 1.6; 95% CI, 1.1- 2.4; 27 patients), and lung (SIR, 2.0; 95% CI, 1.3- 2.8; 31 patients) and for lymphoma (SIR, 2.0; 95% CI, 1.4- 2.9; 29 patients). There was a nonsignificant 50% excess risk for nonmelanoma skin cancer (SIR, 1.5; 95% CI, 0.8- 2.6; 12 patients), seemingly confined to men and to the first 10 years of follow- up. Malignant melanoma did not occur more often than expected. Conclusions: The observed risk elevations, all of borderline statistical significance, should be interpreted cautiously. We could not control for possible confounding by cases of cancer caused by smoking, and the combination of multiple significance testing and few observed patients may have generated chance findings.
