Carbohydrates,lipids,and proteins are the three major nutrients required by the human body.The lipids,comprising triglycerides,phospholipids,and sterols,provide energy and essential fatty acids for the body,and are re...Carbohydrates,lipids,and proteins are the three major nutrients required by the human body.The lipids,comprising triglycerides,phospholipids,and sterols,provide energy and essential fatty acids for the body,and are required for the growth and maintenance of human cells and tissues.A variety of lipid molecules and their intermediates are involved in cell signaling and inflammation,and have been reported to promote tumor transformation and progression.Fatty acid biosynthetic enzymes are also involved in the lipid metabolism of tumors.Dyslipidemia is closely related to many solid tumors,and may both play a role in both tumorigenesis and be a consequence of tumor development.Therefore,abnormal lipid metabolism is strongly associated with tumor transformation and progression.This review discusses the signaling pathways,related genes,enzymes,and inflammatory cell factors involved in tumor lipid metabolism,as well as the roles of dyslipidemia in tumor transformation and progression.We believe the information provided will serve as valuable reference highlighting molecules that can be targeted to improve the treatment of tumors.展开更多
The morbidity of lung cancer has increased rapidly in recent decades.Non-small cell lung cancer(NSCLC)accounts for 80%-85% of total lung cancer cases.The molecular mechanism associated with NSCLC remains unclear.Micro...The morbidity of lung cancer has increased rapidly in recent decades.Non-small cell lung cancer(NSCLC)accounts for 80%-85% of total lung cancer cases.The molecular mechanism associated with NSCLC remains unclear.MicroRNAs(miRNAs)play an important role at the post-transcriptional level.NSCLC-associated pathways targeted by NSCLC-related miRNAs(NSCLC-miRNAs)have not been fully investigated.In a previous study,we have demonstrated 10 miRNAs are overexpressed in NSCLC and can be used as biomarkers for NSCLC diagnosis.In the present study,we found that five of the 10 miRNAs were downregulated in several common cancers.We analyzed the protein classes,molecular functions,biological functions,and signaling pathways targeted by the 5 NSCLC-related miRNAs and four main canonical pathways,identifying potential new targets for future clinical applications.展开更多
Ferroptosis is a novel form of regulated cell death distinguished from apoptosis,autophagy and other forms of cell death.It is characterized by the iron-dependent accumulation of reactive oxygen species to lethal leve...Ferroptosis is a novel form of regulated cell death distinguished from apoptosis,autophagy and other forms of cell death.It is characterized by the iron-dependent accumulation of reactive oxygen species to lethal levels.The inducers of cell ferroptosis react with glutathione peroxidase or lead to glutathione depletion through diverse pathways to decrease the antioxidant capacity and increase the level of reactive oxygen species.Multiple metabolic disorders and the disrupted homeostasis associated with a wide variety of ailments,including cancer,can lead to ferroptosis.The present review provides an overview of the mechanisms underlying ferroptosis,highlights the role of ferroptosis in cancer,and discusses the therapeutic potential of targeting ferroptosis.展开更多
基金This work was supported by the National Natural Science Foundation of China(Grant No.81772629 and 81974374).
文摘Carbohydrates,lipids,and proteins are the three major nutrients required by the human body.The lipids,comprising triglycerides,phospholipids,and sterols,provide energy and essential fatty acids for the body,and are required for the growth and maintenance of human cells and tissues.A variety of lipid molecules and their intermediates are involved in cell signaling and inflammation,and have been reported to promote tumor transformation and progression.Fatty acid biosynthetic enzymes are also involved in the lipid metabolism of tumors.Dyslipidemia is closely related to many solid tumors,and may both play a role in both tumorigenesis and be a consequence of tumor development.Therefore,abnormal lipid metabolism is strongly associated with tumor transformation and progression.This review discusses the signaling pathways,related genes,enzymes,and inflammatory cell factors involved in tumor lipid metabolism,as well as the roles of dyslipidemia in tumor transformation and progression.We believe the information provided will serve as valuable reference highlighting molecules that can be targeted to improve the treatment of tumors.
基金grants from the National Natural Science Foundation of China(No.81372394,81602158,81602156,and 81572321)and Tianjin Health and Family Planning Commission Foundation of Science and Technology(15KG142).This work was also supported by CSCO-Merck Serono Oncology Research Fund(Y-MX2015-092)and Tianjin Science Foundation(No.15JCYBJC28200).The funders had no role in study designin collection,analysis,and interpretation of data+1 种基金in the writing of the reportand in the decision to submit this article for publication.
文摘The morbidity of lung cancer has increased rapidly in recent decades.Non-small cell lung cancer(NSCLC)accounts for 80%-85% of total lung cancer cases.The molecular mechanism associated with NSCLC remains unclear.MicroRNAs(miRNAs)play an important role at the post-transcriptional level.NSCLC-associated pathways targeted by NSCLC-related miRNAs(NSCLC-miRNAs)have not been fully investigated.In a previous study,we have demonstrated 10 miRNAs are overexpressed in NSCLC and can be used as biomarkers for NSCLC diagnosis.In the present study,we found that five of the 10 miRNAs were downregulated in several common cancers.We analyzed the protein classes,molecular functions,biological functions,and signaling pathways targeted by the 5 NSCLC-related miRNAs and four main canonical pathways,identifying potential new targets for future clinical applications.
基金the National Natural Science Foundation of China(No.81772629,81772843,81702431,81702275,81702437,81602158 and 81602156)the Tianjin Health and Family Planning Commission Foundation of Science and Technology(No.15KG142)+2 种基金the Nature Science Foundation of Tianjin City(No.16PTSYJC00170)The funders had no role in the study design,collection,analysisinterpretation of the data,in the writing of the report,or in the decision to submit this article for publication.
文摘Ferroptosis is a novel form of regulated cell death distinguished from apoptosis,autophagy and other forms of cell death.It is characterized by the iron-dependent accumulation of reactive oxygen species to lethal levels.The inducers of cell ferroptosis react with glutathione peroxidase or lead to glutathione depletion through diverse pathways to decrease the antioxidant capacity and increase the level of reactive oxygen species.Multiple metabolic disorders and the disrupted homeostasis associated with a wide variety of ailments,including cancer,can lead to ferroptosis.The present review provides an overview of the mechanisms underlying ferroptosis,highlights the role of ferroptosis in cancer,and discusses the therapeutic potential of targeting ferroptosis.
