Objective： To study the effects and mechanism of homocysteine（Hcy） on Parkinson＇ s disease（PD） induced by 6-hydroxydopamine （6-OHDA） in vivo. Methods：Forty rats were divided into 4 groups. 6-OHDA or the solve...Objective： To study the effects and mechanism of homocysteine（Hcy） on Parkinson＇ s disease（PD） induced by 6-hydroxydopamine （6-OHDA） in vivo. Methods：Forty rats were divided into 4 groups. 6-OHDA or the solvent of 6-OHDA was focally administrated to induce PD, 2 h later Hcy or 0.9% sodium chloride was administrated in the ipsolateral substantial nigra（SN）. We Used behavioral testing, Immolunohistochemical techniques, biochemistry techniques to detect the injury of SN. Results：The rotary turns of PD rats induced by 6-OHDA showed significant increase after treatment with Hcy compared with the controls（P 〈 0.05）. Also the numbers of tyrosine hydroxylase（TH）-stained neurons were decreased, and dendrites were fragmented and truncated. Free radicals were increased and antioxidaat enzymes decreased. Conclusion：Focal infusion of Hcy into the SN increased the vulnerability of the doparninergic neurons to 6-OHDA-induced degeneration, it seems that the endangering effect of Hcy is due to exacerbating oxidative stress.展开更多
A diastereoselectivity-controllable formal[3+2]-cycloaddition of arylvinyl oxirane 2,2-diesters with cyclic N-sulfonyl imines is developed,affording the corresponding tricyclic oxazolidine derivatives in moderate to e...A diastereoselectivity-controllable formal[3+2]-cycloaddition of arylvinyl oxirane 2,2-diesters with cyclic N-sulfonyl imines is developed,affording the corresponding tricyclic oxazolidine derivatives in moderate to excellent yields with excellent diastereoselectivities in the presence of palladium(0)or scandium(III)triflate.This protocol allows selective synthesis of diastereomers of tricyclic oxazolidine derivatives under switchable and mild conditions.Further transformations of the obtained products were conducted by removing ester groups and arylvinyl moieties.展开更多
基金National Natural Sciences Foundation of China(No.30300114)
文摘Objective： To study the effects and mechanism of homocysteine（Hcy） on Parkinson＇ s disease（PD） induced by 6-hydroxydopamine （6-OHDA） in vivo. Methods：Forty rats were divided into 4 groups. 6-OHDA or the solvent of 6-OHDA was focally administrated to induce PD, 2 h later Hcy or 0.9% sodium chloride was administrated in the ipsolateral substantial nigra（SN）. We Used behavioral testing, Immolunohistochemical techniques, biochemistry techniques to detect the injury of SN. Results：The rotary turns of PD rats induced by 6-OHDA showed significant increase after treatment with Hcy compared with the controls（P 〈 0.05）. Also the numbers of tyrosine hydroxylase（TH）-stained neurons were decreased, and dendrites were fragmented and truncated. Free radicals were increased and antioxidaat enzymes decreased. Conclusion：Focal infusion of Hcy into the SN increased the vulnerability of the doparninergic neurons to 6-OHDA-induced degeneration, it seems that the endangering effect of Hcy is due to exacerbating oxidative stress.
基金supported by the National Natural Science Foundation of China(21861008,21761006)Guangxi Natural Science Foundation(2018GXNSFBA138037)+1 种基金Department of Science and Technology of Guangxi(AD19245049)“BAGUI Scholar”Program of Guangxi Province of China。
文摘A diastereoselectivity-controllable formal[3+2]-cycloaddition of arylvinyl oxirane 2,2-diesters with cyclic N-sulfonyl imines is developed,affording the corresponding tricyclic oxazolidine derivatives in moderate to excellent yields with excellent diastereoselectivities in the presence of palladium(0)or scandium(III)triflate.This protocol allows selective synthesis of diastereomers of tricyclic oxazolidine derivatives under switchable and mild conditions.Further transformations of the obtained products were conducted by removing ester groups and arylvinyl moieties.
