The morbidity of lung cancer has increased rapidly in recent decades.Non-small cell lung cancer(NSCLC)accounts for 80%-85% of total lung cancer cases.The molecular mechanism associated with NSCLC remains unclear.Micro...The morbidity of lung cancer has increased rapidly in recent decades.Non-small cell lung cancer(NSCLC)accounts for 80%-85% of total lung cancer cases.The molecular mechanism associated with NSCLC remains unclear.MicroRNAs(miRNAs)play an important role at the post-transcriptional level.NSCLC-associated pathways targeted by NSCLC-related miRNAs(NSCLC-miRNAs)have not been fully investigated.In a previous study,we have demonstrated 10 miRNAs are overexpressed in NSCLC and can be used as biomarkers for NSCLC diagnosis.In the present study,we found that five of the 10 miRNAs were downregulated in several common cancers.We analyzed the protein classes,molecular functions,biological functions,and signaling pathways targeted by the 5 NSCLC-related miRNAs and four main canonical pathways,identifying potential new targets for future clinical applications.展开更多
Ferroptosis is a novel form of regulated cell death distinguished from apoptosis,autophagy and other forms of cell death.It is characterized by the iron-dependent accumulation of reactive oxygen species to lethal leve...Ferroptosis is a novel form of regulated cell death distinguished from apoptosis,autophagy and other forms of cell death.It is characterized by the iron-dependent accumulation of reactive oxygen species to lethal levels.The inducers of cell ferroptosis react with glutathione peroxidase or lead to glutathione depletion through diverse pathways to decrease the antioxidant capacity and increase the level of reactive oxygen species.Multiple metabolic disorders and the disrupted homeostasis associated with a wide variety of ailments,including cancer,can lead to ferroptosis.The present review provides an overview of the mechanisms underlying ferroptosis,highlights the role of ferroptosis in cancer,and discusses the therapeutic potential of targeting ferroptosis.展开更多
Increasing research suggests that cancer is a metabolic disease.During tumor development,cancer cells increase their biosynthetic and bioenergetic demands to maintain tumor cell proliferation and metastasis.The focus ...Increasing research suggests that cancer is a metabolic disease.During tumor development,cancer cells increase their biosynthetic and bioenergetic demands to maintain tumor cell proliferation and metastasis.The focus of research on this topic has been on the metabolism of the primary tumor,while metabolic adjustments during primary tumor growth/progression and metastatic processes have not been extensively investigated.The current evidence indicates that the metabolism during tumor development is dynamic.Moreover,emerging data suggest that,once the tumor cells leave their primary sites,they may show different metabolic features distinct from the primary tumor,enabling them to successfully survive and metastasize.In this review,we summarize how this metabolic flexibility occurs during the growth of the primary tumor and the metastatic process,and also explore how metabolic adaptation is influenced by the microenvironments of the tumor cells.We hope that this review will provide inspiration and guidance for future research on tumor metabolism.展开更多
基金grants from the National Natural Science Foundation of China(No.81372394,81602158,81602156,and 81572321)and Tianjin Health and Family Planning Commission Foundation of Science and Technology(15KG142).This work was also supported by CSCO-Merck Serono Oncology Research Fund(Y-MX2015-092)and Tianjin Science Foundation(No.15JCYBJC28200).The funders had no role in study designin collection,analysis,and interpretation of data+1 种基金in the writing of the reportand in the decision to submit this article for publication.
文摘The morbidity of lung cancer has increased rapidly in recent decades.Non-small cell lung cancer(NSCLC)accounts for 80%-85% of total lung cancer cases.The molecular mechanism associated with NSCLC remains unclear.MicroRNAs(miRNAs)play an important role at the post-transcriptional level.NSCLC-associated pathways targeted by NSCLC-related miRNAs(NSCLC-miRNAs)have not been fully investigated.In a previous study,we have demonstrated 10 miRNAs are overexpressed in NSCLC and can be used as biomarkers for NSCLC diagnosis.In the present study,we found that five of the 10 miRNAs were downregulated in several common cancers.We analyzed the protein classes,molecular functions,biological functions,and signaling pathways targeted by the 5 NSCLC-related miRNAs and four main canonical pathways,identifying potential new targets for future clinical applications.
基金the National Natural Science Foundation of China(No.81772629,81772843,81702431,81702275,81702437,81602158 and 81602156)the Tianjin Health and Family Planning Commission Foundation of Science and Technology(No.15KG142)+2 种基金the Nature Science Foundation of Tianjin City(No.16PTSYJC00170)The funders had no role in the study design,collection,analysisinterpretation of the data,in the writing of the report,or in the decision to submit this article for publication.
文摘Ferroptosis is a novel form of regulated cell death distinguished from apoptosis,autophagy and other forms of cell death.It is characterized by the iron-dependent accumulation of reactive oxygen species to lethal levels.The inducers of cell ferroptosis react with glutathione peroxidase or lead to glutathione depletion through diverse pathways to decrease the antioxidant capacity and increase the level of reactive oxygen species.Multiple metabolic disorders and the disrupted homeostasis associated with a wide variety of ailments,including cancer,can lead to ferroptosis.The present review provides an overview of the mechanisms underlying ferroptosis,highlights the role of ferroptosis in cancer,and discusses the therapeutic potential of targeting ferroptosis.
文摘Increasing research suggests that cancer is a metabolic disease.During tumor development,cancer cells increase their biosynthetic and bioenergetic demands to maintain tumor cell proliferation and metastasis.The focus of research on this topic has been on the metabolism of the primary tumor,while metabolic adjustments during primary tumor growth/progression and metastatic processes have not been extensively investigated.The current evidence indicates that the metabolism during tumor development is dynamic.Moreover,emerging data suggest that,once the tumor cells leave their primary sites,they may show different metabolic features distinct from the primary tumor,enabling them to successfully survive and metastasize.In this review,we summarize how this metabolic flexibility occurs during the growth of the primary tumor and the metastatic process,and also explore how metabolic adaptation is influenced by the microenvironments of the tumor cells.We hope that this review will provide inspiration and guidance for future research on tumor metabolism.
