Retrospective Study Efficacy of pantoprazole plus perforation repair for peptic ulcer and its effect on the stress response

BACKGROUND Peptic ulcer(PU)is an abnormal phenomenon in which there is rupture of the mucosa of the digestive tract,which not only affects patients'normal life but also causes an economic burden due to its high medical costs.AIM To investigate the efficacy of pantoprazole(PPZ)plus perforation repair in patients with PU and its effect on the stress response.METHODS The study subjects were 108 PU patients admitted between July 2018 and July 2022,including 58 patients receiving PPZ plus perforation repair[research group(RG)]and 50 patients given simple perforation repair[control group(CG)].The efficacy,somatostatin(SS)concentration,stress reaction[malondialdehyde(MDA),lipid peroxide(LPO)],inflammatory indices[tumor necrosis factor(TNF)-α,C-reactive protein(CRP),interleukin(IL)-1β],recurrence,and complications(perforation,hemorrhage,and pyloric obstruction)were compared.RESULTS The overall response rate was higher in the RG than in the CG.Patients in the RG and IL-1β were significantly reduced to lower levels than those in the CG.Lower recurrence and complication rates were identified in the RG group.CONCLUSION Therefore,PPZ plus perforation repair is conducive to enhancing treatment outcomes in PU patients,reducing oxidative stress injury and excessive inflammatory reactions,and contributing to low recurrence and complication rates.

Bibliometric analysis of Wendan decoction research based on the Web of Science database

Objective:With the development of Wendan decoction(WDD)and more literature on the research of WDD,we aimed to present an insight into WDD research using bibliometric analysis.Methods:We retrieved data from the Web of Science database from 2008 to 2022.Publication trends were examined using data from journals,authors,institutions,international collaborations,citations,and keywords from the online analytical platform Bibliometric(http://bibliometric.com).Results:Over the years,an increase in the use of keywords,including depression,insomnia,Alzheimer’s disease,schizophrenia,hippocampus,and insomnia,was observed.The outcomes of the analysis revealed that topics related to WDD have become increasingly prevalent in the last five years,and the internationally recognized application of WDD is mainly neuropsychiatric diseases.Conclusion:We exhibited WDD research progress by identifying and evaluating WDD-focused articles.Our analysis revealed the trend of the topics from 2008 to 2022,which can assist scholars in identifying future trends.

miRNA polymorphisms and risk of gastric cancer in Asian population

miRNAs are endogenous 19-to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation.Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene.miRNA-singlenucleotide polymorphisms(SNPs),as a novel class of functional SNPs/polymorphisms,have been identified as candidate biomarkers for gastric cancer susceptibility.On the basis of recent data,the present review summarizes current knowledge of the functional effects of miRNA-SNPs and their importance as candidate gastric cancer biomarkers.Additionally,this review also includes a meta-analysis of the most frequently studied miRNA-SNPs in gastric cancer.