Objective:Use data mining techniques to explore the rule of Chinese medicine used for airway remodeling.Methods:Search the literature on Chinese medicine use for airway remodeling in the past 20 years.With the help of...Objective:Use data mining techniques to explore the rule of Chinese medicine used for airway remodeling.Methods:Search the literature on Chinese medicine use for airway remodeling in the past 20 years.With the help of WPS Office Excel 11.1,IBM SPSS Statistics 23.0 and SPSS Modeler 18.0 software,prescriptions were analyzed for the frequency of drug use,the four natures,the five flavours and the channel tropism,cluster analysis and association analysis of high-frequency drugs.Results:There were 58 Chinese medicine prescriptions for airway remodeling be found,involving 105 Chinese medicines,the most frequent channel tropism were spleen,stomach,lung,large intestine,liver and gallbladder,the most frequent use of the five flavors was sour,sweet and pungent,the highest frequency of the four natures was cold and hot,cluster analysis yielded eight drug aggregation groups,and association rule analysis yielded five groups of high-frequency drug pairs.Conclusion:The main TCM treatments for airway remodeling are expelling phlegm,relieving cough,asthma calming,expelling blood stasis and deficiency tonifying.The results of this study can provide ideas for compounding and drug selection for subsequent studies.展开更多
目的:探讨3.2mm透明角膜切口白内障超声乳化吸除术(Phaco)联合人工晶状体(IOL)植入术治疗白内障的疗效。方法:回顾性分析2015-10/2016-10我院眼科接诊的白内障患者95例107眼,均行3.2mm透明角膜切口Phaco联合IOL植入术,观察术后视力、角...目的:探讨3.2mm透明角膜切口白内障超声乳化吸除术(Phaco)联合人工晶状体(IOL)植入术治疗白内障的疗效。方法:回顾性分析2015-10/2016-10我院眼科接诊的白内障患者95例107眼,均行3.2mm透明角膜切口Phaco联合IOL植入术,观察术后视力、角膜曲率、角膜散光、前房深度等情况。结果:术后3d,1wk,1mo本组患者裸眼视力(0.16±0.06、0.15±0.05、0.14±0.04)明显优于术前(0.48±0.15),前房深度(3.86±1.09、3.69±1.04、3.84±1.07mm)明显高于术前(2.71±0.88mm)(均 P <0.05),但角膜曲率和角膜散光度与术前无明显差异,且术后各时间点手术源性散光度无差异(均 P >0.05)。结论:3.2mm透明角膜切口Phaco联合IOL植入术可有效改善视力,减小角膜散光,是治疗白内障安全有效的手术方式。展开更多
Objective: To explore the molecular mechanism of Magnoliae Flos and Xanthii Fructus herb pair for allergic rhinitis based on network pharmacology. Methods: From the Traditional Chinese Medicine Systems Pharmacology da...Objective: To explore the molecular mechanism of Magnoliae Flos and Xanthii Fructus herb pair for allergic rhinitis based on network pharmacology. Methods: From the Traditional Chinese Medicine Systems Pharmacology database, Uniprot database, and Gene Cards database, the relevant chemical constituents information, pharmacokinetic information and hub target of allergic rhinitis were obtained. The protein-protein interaction network was constructed by STRING online database, analyzed and showed by the Cytoscape software. The screened target information was analyzed by the Metascape database for Gene Ontology biological function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. Results: Main components of Magnoliae Flos and Xanthii Fructus herb pair, such as aloe-emodin, stigmasterol, beta-sitosterol and Yangambin, depend on the interaction of Nitric Oxide Synthase 3, Tumor Necrosis Factor, Caspase-3 and other functions involve G protein-coupled (amine) receptor activity, RNA polymerase II basic transcription factor binding, protease binding, heme binding, and integrin binding;can regulate calcium signal pathway, serotonergic synapse, Kyoto Encyclopedia of Genes and Genomes signal pathway, tryptophan inflammatory mediator regulation pathway, estrogen signal pathway alone or in combination, and play a role in the treatment of allergic rhinitis. Conclusion: Magnoliae Flos combined with Xanthii Fructus can regulate biomolecular network in multiple targets and pathways to treat allergic rhinitis.展开更多
Nanofiltration(NF)membranes as high selective separators are appealing for molecular sieving,which still remains a great challenge for the mixed dyes with same charge.In this study,cellulose acetate(CA)membranes were ...Nanofiltration(NF)membranes as high selective separators are appealing for molecular sieving,which still remains a great challenge for the mixed dyes with same charge.In this study,cellulose acetate(CA)membranes were firstly aminated by ethylene imine polymer(PEI),and then the thin film of metal organic frameworks(MOFs)were constructed onto aminated CA membrane through forward-diffusion,slow crystallization and in situ growth of Fe Co-Prussian blue(FeCo-PB)crystallization layers.The designed PB@CA composite NF membrane shows an ideal rejection for Congo red(CR)/methyl orange(MO)mixture solution,with 99.7%±0.2%for CR and 33.5%±2%for MO.In addition,the composite NF membrane demonstrated good efficiency for photocatalytic degradation of organic fouling(permeability recovery ratio was up to 92%)due to the active FeCo-PB micro-cubes.Thus,this work provides a practical strategy to prepare MOFs mediated thin film composite nanofiltration membrane for precise molecular sieving and catalytic antifouling performances.展开更多
Objective To predict the main bioactive components and potential mechanisms of Ephedra Herba Decoction(Chinese Pinyin abbreviated as MHT)in treating influenza A virus(IAV)based on network pharmacology.Methods Multiple...Objective To predict the main bioactive components and potential mechanisms of Ephedra Herba Decoction(Chinese Pinyin abbreviated as MHT)in treating influenza A virus(IAV)based on network pharmacology.Methods Multiple online databases were used to search and screen out the active components from MHT,the related targets of active components of MHT and the genes related to IAV.Search the corresponding genes name of target through UniProt database.Cytoscape 3.7.2 was used to construct the drug-component-target network diagram.Venn diagram was used to screen the intersection genes of the active components corresponding to the target and disease-related genes,and the intersection genes were imported into the STRING Database Online platform to obtain the protein-protein interaction(PPI)network.Then,the PPI network was imported into Cytoscape 3.7.2 to obtain the core targets.Finally,Wei Sheng Xing(http://www.bioinformatics.com.cn/)was used to do GO function enrichment analysis and KEGG signaling pathway enrichment analysis for the intersection genes,and the results of GO and KEGG were visualized.Results A total of 116 active components and 253 potential targets were screened from MHT.Quercetin,Kaempferol,and Luteolin are the main active components,and AKT1,TNF,TP53,IL6,and JUN are the core targets of 253 potential targets.There are 2906 targets of influenza A,including 121 intersection genes.Enrichment analysis showed that there were 131 entries of molecular function,89 entries of cell component,1645 entries of biological process and 195 entries of signaling pathway.PI3K-Akt,MAPK,and JAK-STAT were the main signaling pathways.Conclusion MHT plays an important role in the prevention and treatment of influenza A by acting on multiple targets and multiple signaling pathways.展开更多
Drug Combination Therapy has retracted this article because the data is falsified,the core targets are wrong and this English article has a high repetition rate compared with a Chinese article.Drug Combination Therapy...Drug Combination Therapy has retracted this article because the data is falsified,the core targets are wrong and this English article has a high repetition rate compared with a Chinese article.Drug Combination Therapy received the author’s manuscript on 13 April 2022.After the plagiarism check on 13 April 2022,the similarity rate of this article was 15%(Supplementary 1),which was qualified.Then the manuscript was started to be sent for peer-review at 10:10 on 19 April 2022.展开更多
Objective:To explore the epidemiological characteristics of Corona Virus Disease 2019(COVID-19)Delta variant infection in children in Xi'an and Baoji.Methods:According to the official information released by Shaan...Objective:To explore the epidemiological characteristics of Corona Virus Disease 2019(COVID-19)Delta variant infection in children in Xi'an and Baoji.Methods:According to the official information released by Shaanxi Province,the information of confirmed cases in Xi'an(December 20,2021 to January 8,2022)and Baoji(March 8 to March 27,2022)were collected respectively.Records include age,sex,residential address,community and other basic information.Isolation mode,isolation time,morbidity and positive time of viral nucleic acid test,vaccination,clinical typing,close contact personnel,cluster incidence situation and the social activity tracking of the confirmed cases were collected,and the data were statistically analyzed.Results:In 20 days,there were 281 infected children in Xi'an,accounting for 14.48%of the total cases(1,940 cases),including 154 boys(54.8%)and 127 girls(45.20%).The number of diagnosed children in Baoji City(55 cases)is 19.57%of that in Xi'an(55/281),but accounts for 23.31%of the total number of cases(236 cases)in Baoji(this ratio is higher than that of 14.48%in Xi'an).Among the 55 cases of children,there are 33 males(60.00%)and 22 females(40.00%).The proportion of male children in both cities is higher.The median age of diagnosed children in Xi'an was 7.0 years(IQR:1.0-13.0 years old),and the age range was 4 d-18 years old,while the median age of Baoji children was 9.0 years old(IQR:5.0-17.0 years old),ranging from 3 months to 18 years old.The number of children vaccinated in Xi'an and Baoji was positively correlated with the number of infected children.The vaccination rates of children in Xi'an and Baoji were 64.06%and 52.73%,respectively.The vaccination rates of infants(≤1 year old)in both cities were 18.52%and 14.29%,respectively.On the whole,the number of new child cases in the two cities increased first and then decreased.The peak number of new child cases in Xi'an was 39(10th day of statistics),while that of Baoji was 13(6th day of statistics).The peak in Xi'an comes later and the epidemic lasts longer.Among the children in Xi'an,201(71.53%)had a history of close contact,55(19.57%)had no clear history of COVID-19 infection,and were positive after actively participating in the nucleic acid test of all members of the community,of which 54(98.18%)were primary and middle school students.54 cases(98.18%)of Baoji children had a history of close contact,of which 20 cases were infected by the confirmed case number 62 officially announced on March 10.The time to be positive for viral nucleic acid test in children after isolation was 1-14 days.The positive rate of children in Xi'an reached 85.41%(240/281)after 7 days of isolation,and the highest peak of positive detection was on the third day of isolation(84 cases).After 7 days of isolation,45 cases were positive in Baoji,accounting for 81.82%(45/55).The highest peak of positive detection was on the 5th day of isolation(11 cases).The regional distribution of infected children in Xi'an was the highest in Yanta District(137 cases),followed by High-tech Zone(42 cases)and Lianhu District(29 cases).The main manifestations of COVID-19 in Xi'an were light(278 cases,98.93%),common type(3 cases,1.07%),light in Baoji(54 cases,98.18%),and common type(1 case,1.82%).Through general clinical treatment(including traditional Chinese medicine treatment and symptomatic treatment),all were cured.Conclusion:Delta variant increases the susceptibility of children to infection,which spreads rapidly mainly through close family contact and community concealment,so it is necessary to study better early diagnosis and prevention and control measures.展开更多
Under the assumption that μ is a non-doubling measure on R^d which only satisfies the polynomial growth condition, the authors obtain the boundedness of the multilinear fractional integrals on Morrey spaces, weak-Mor...Under the assumption that μ is a non-doubling measure on R^d which only satisfies the polynomial growth condition, the authors obtain the boundedness of the multilinear fractional integrals on Morrey spaces, weak-Morrey spaces and Lipschitz spaces associated with it, which, in the case when μ is the d-dimensional Lebesgue measure, also improve the known results.展开更多
A supercritical carbon dioxide(Sc CO2) assisted phase inversion was developed to produce microporous poly(vinylidene fluoride)(PVDF) membranes whose morphology characteristics arise from both liquid-liquid demix...A supercritical carbon dioxide(Sc CO2) assisted phase inversion was developed to produce microporous poly(vinylidene fluoride)(PVDF) membranes whose morphology characteristics arise from both liquid-liquid demixing and solid-liquid demixing(crystallization). This result was confirmed by Fourier transform infrared spectroscopy(FTIR), from which both α and β crystals were found. As revealed by contact angle experiment, the PVDF membranes prepared via Sc CO2 assisted phase inversion were more hydrophobic compared with the control membrane produced via conventional immersionprecipitation technique. In particular, the sample with 15 wt% PVDF prepared at 45 °C and 13 MPa exhibited a contact angle of 142°, which was mainly caused by the multilevel micro- and nano- structure. The effects of polyethylene glycol(PEG), polyvinyl pyrrolidone(PVP) and lithium chloride(Li Cl) on the structures and crystal form were investigated. PVP promoted the formation of β phase crystal form, while PEG boosts the evolution of α phase. Li Cl restrained the crystallization degree of PVDF membrane under Sc CO2.展开更多
文摘Objective:Use data mining techniques to explore the rule of Chinese medicine used for airway remodeling.Methods:Search the literature on Chinese medicine use for airway remodeling in the past 20 years.With the help of WPS Office Excel 11.1,IBM SPSS Statistics 23.0 and SPSS Modeler 18.0 software,prescriptions were analyzed for the frequency of drug use,the four natures,the five flavours and the channel tropism,cluster analysis and association analysis of high-frequency drugs.Results:There were 58 Chinese medicine prescriptions for airway remodeling be found,involving 105 Chinese medicines,the most frequent channel tropism were spleen,stomach,lung,large intestine,liver and gallbladder,the most frequent use of the five flavors was sour,sweet and pungent,the highest frequency of the four natures was cold and hot,cluster analysis yielded eight drug aggregation groups,and association rule analysis yielded five groups of high-frequency drug pairs.Conclusion:The main TCM treatments for airway remodeling are expelling phlegm,relieving cough,asthma calming,expelling blood stasis and deficiency tonifying.The results of this study can provide ideas for compounding and drug selection for subsequent studies.
文摘目的:探讨3.2mm透明角膜切口白内障超声乳化吸除术(Phaco)联合人工晶状体(IOL)植入术治疗白内障的疗效。方法:回顾性分析2015-10/2016-10我院眼科接诊的白内障患者95例107眼,均行3.2mm透明角膜切口Phaco联合IOL植入术,观察术后视力、角膜曲率、角膜散光、前房深度等情况。结果:术后3d,1wk,1mo本组患者裸眼视力(0.16±0.06、0.15±0.05、0.14±0.04)明显优于术前(0.48±0.15),前房深度(3.86±1.09、3.69±1.04、3.84±1.07mm)明显高于术前(2.71±0.88mm)(均 P <0.05),但角膜曲率和角膜散光度与术前无明显差异,且术后各时间点手术源性散光度无差异(均 P >0.05)。结论:3.2mm透明角膜切口Phaco联合IOL植入术可有效改善视力,减小角膜散光,是治疗白内障安全有效的手术方式。
基金This study was supported by the Discipline Innovation Team Construction Project of the Second Affiliated Hospital of Shaanxi University of Chinese Medicine(2020XKTD-A02).
文摘Objective: To explore the molecular mechanism of Magnoliae Flos and Xanthii Fructus herb pair for allergic rhinitis based on network pharmacology. Methods: From the Traditional Chinese Medicine Systems Pharmacology database, Uniprot database, and Gene Cards database, the relevant chemical constituents information, pharmacokinetic information and hub target of allergic rhinitis were obtained. The protein-protein interaction network was constructed by STRING online database, analyzed and showed by the Cytoscape software. The screened target information was analyzed by the Metascape database for Gene Ontology biological function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. Results: Main components of Magnoliae Flos and Xanthii Fructus herb pair, such as aloe-emodin, stigmasterol, beta-sitosterol and Yangambin, depend on the interaction of Nitric Oxide Synthase 3, Tumor Necrosis Factor, Caspase-3 and other functions involve G protein-coupled (amine) receptor activity, RNA polymerase II basic transcription factor binding, protease binding, heme binding, and integrin binding;can regulate calcium signal pathway, serotonergic synapse, Kyoto Encyclopedia of Genes and Genomes signal pathway, tryptophan inflammatory mediator regulation pathway, estrogen signal pathway alone or in combination, and play a role in the treatment of allergic rhinitis. Conclusion: Magnoliae Flos combined with Xanthii Fructus can regulate biomolecular network in multiple targets and pathways to treat allergic rhinitis.
基金International Partnership Program of Chinese Academy of Sciences-Grand Challenges(No.181GJHZ2022038GC)Key Research and Development Program of Zhejiang Province,China(No.2021C03170)+4 种基金Ten thousand plan-high level talents special support plan of Zhejiang province,China(No.ZJWR0108020)National Natural Science Foundation of China(No.51973230)Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars(No.LR20E030002)“Science and Technology Innovation 2025”Major Project of Ningbo(No.2020Z105)Youth Innovation Promotion Association of Chinese Academy of Science(No.2014258).
文摘Nanofiltration(NF)membranes as high selective separators are appealing for molecular sieving,which still remains a great challenge for the mixed dyes with same charge.In this study,cellulose acetate(CA)membranes were firstly aminated by ethylene imine polymer(PEI),and then the thin film of metal organic frameworks(MOFs)were constructed onto aminated CA membrane through forward-diffusion,slow crystallization and in situ growth of Fe Co-Prussian blue(FeCo-PB)crystallization layers.The designed PB@CA composite NF membrane shows an ideal rejection for Congo red(CR)/methyl orange(MO)mixture solution,with 99.7%±0.2%for CR and 33.5%±2%for MO.In addition,the composite NF membrane demonstrated good efficiency for photocatalytic degradation of organic fouling(permeability recovery ratio was up to 92%)due to the active FeCo-PB micro-cubes.Thus,this work provides a practical strategy to prepare MOFs mediated thin film composite nanofiltration membrane for precise molecular sieving and catalytic antifouling performances.
基金This study was supported by the Discipline Innovation Team Construction Project of the Second Affiliated Hospital of Shaanxi University of Chinese Medicine (2020XKTD-A02).
文摘Objective To predict the main bioactive components and potential mechanisms of Ephedra Herba Decoction(Chinese Pinyin abbreviated as MHT)in treating influenza A virus(IAV)based on network pharmacology.Methods Multiple online databases were used to search and screen out the active components from MHT,the related targets of active components of MHT and the genes related to IAV.Search the corresponding genes name of target through UniProt database.Cytoscape 3.7.2 was used to construct the drug-component-target network diagram.Venn diagram was used to screen the intersection genes of the active components corresponding to the target and disease-related genes,and the intersection genes were imported into the STRING Database Online platform to obtain the protein-protein interaction(PPI)network.Then,the PPI network was imported into Cytoscape 3.7.2 to obtain the core targets.Finally,Wei Sheng Xing(http://www.bioinformatics.com.cn/)was used to do GO function enrichment analysis and KEGG signaling pathway enrichment analysis for the intersection genes,and the results of GO and KEGG were visualized.Results A total of 116 active components and 253 potential targets were screened from MHT.Quercetin,Kaempferol,and Luteolin are the main active components,and AKT1,TNF,TP53,IL6,and JUN are the core targets of 253 potential targets.There are 2906 targets of influenza A,including 121 intersection genes.Enrichment analysis showed that there were 131 entries of molecular function,89 entries of cell component,1645 entries of biological process and 195 entries of signaling pathway.PI3K-Akt,MAPK,and JAK-STAT were the main signaling pathways.Conclusion MHT plays an important role in the prevention and treatment of influenza A by acting on multiple targets and multiple signaling pathways.
文摘Drug Combination Therapy has retracted this article because the data is falsified,the core targets are wrong and this English article has a high repetition rate compared with a Chinese article.Drug Combination Therapy received the author’s manuscript on 13 April 2022.After the plagiarism check on 13 April 2022,the similarity rate of this article was 15%(Supplementary 1),which was qualified.Then the manuscript was started to be sent for peer-review at 10:10 on 19 April 2022.
文摘Objective:To explore the epidemiological characteristics of Corona Virus Disease 2019(COVID-19)Delta variant infection in children in Xi'an and Baoji.Methods:According to the official information released by Shaanxi Province,the information of confirmed cases in Xi'an(December 20,2021 to January 8,2022)and Baoji(March 8 to March 27,2022)were collected respectively.Records include age,sex,residential address,community and other basic information.Isolation mode,isolation time,morbidity and positive time of viral nucleic acid test,vaccination,clinical typing,close contact personnel,cluster incidence situation and the social activity tracking of the confirmed cases were collected,and the data were statistically analyzed.Results:In 20 days,there were 281 infected children in Xi'an,accounting for 14.48%of the total cases(1,940 cases),including 154 boys(54.8%)and 127 girls(45.20%).The number of diagnosed children in Baoji City(55 cases)is 19.57%of that in Xi'an(55/281),but accounts for 23.31%of the total number of cases(236 cases)in Baoji(this ratio is higher than that of 14.48%in Xi'an).Among the 55 cases of children,there are 33 males(60.00%)and 22 females(40.00%).The proportion of male children in both cities is higher.The median age of diagnosed children in Xi'an was 7.0 years(IQR:1.0-13.0 years old),and the age range was 4 d-18 years old,while the median age of Baoji children was 9.0 years old(IQR:5.0-17.0 years old),ranging from 3 months to 18 years old.The number of children vaccinated in Xi'an and Baoji was positively correlated with the number of infected children.The vaccination rates of children in Xi'an and Baoji were 64.06%and 52.73%,respectively.The vaccination rates of infants(≤1 year old)in both cities were 18.52%and 14.29%,respectively.On the whole,the number of new child cases in the two cities increased first and then decreased.The peak number of new child cases in Xi'an was 39(10th day of statistics),while that of Baoji was 13(6th day of statistics).The peak in Xi'an comes later and the epidemic lasts longer.Among the children in Xi'an,201(71.53%)had a history of close contact,55(19.57%)had no clear history of COVID-19 infection,and were positive after actively participating in the nucleic acid test of all members of the community,of which 54(98.18%)were primary and middle school students.54 cases(98.18%)of Baoji children had a history of close contact,of which 20 cases were infected by the confirmed case number 62 officially announced on March 10.The time to be positive for viral nucleic acid test in children after isolation was 1-14 days.The positive rate of children in Xi'an reached 85.41%(240/281)after 7 days of isolation,and the highest peak of positive detection was on the third day of isolation(84 cases).After 7 days of isolation,45 cases were positive in Baoji,accounting for 81.82%(45/55).The highest peak of positive detection was on the 5th day of isolation(11 cases).The regional distribution of infected children in Xi'an was the highest in Yanta District(137 cases),followed by High-tech Zone(42 cases)and Lianhu District(29 cases).The main manifestations of COVID-19 in Xi'an were light(278 cases,98.93%),common type(3 cases,1.07%),light in Baoji(54 cases,98.18%),and common type(1 case,1.82%).Through general clinical treatment(including traditional Chinese medicine treatment and symptomatic treatment),all were cured.Conclusion:Delta variant increases the susceptibility of children to infection,which spreads rapidly mainly through close family contact and community concealment,so it is necessary to study better early diagnosis and prevention and control measures.
基金Supported by the National Natural Science Foundation of China(No.10871025)
文摘Under the assumption that μ is a non-doubling measure on R^d which only satisfies the polynomial growth condition, the authors obtain the boundedness of the multilinear fractional integrals on Morrey spaces, weak-Morrey spaces and Lipschitz spaces associated with it, which, in the case when μ is the d-dimensional Lebesgue measure, also improve the known results.
基金financially supported by the National Natural Science Foundation of China(No.51273211)the National High Technology Research and Development Program(863 program)of China(No.2012AA03A605)the international cooperation project from Ministry of Science and Technology of China(No.2012DFR50470)
文摘A supercritical carbon dioxide(Sc CO2) assisted phase inversion was developed to produce microporous poly(vinylidene fluoride)(PVDF) membranes whose morphology characteristics arise from both liquid-liquid demixing and solid-liquid demixing(crystallization). This result was confirmed by Fourier transform infrared spectroscopy(FTIR), from which both α and β crystals were found. As revealed by contact angle experiment, the PVDF membranes prepared via Sc CO2 assisted phase inversion were more hydrophobic compared with the control membrane produced via conventional immersionprecipitation technique. In particular, the sample with 15 wt% PVDF prepared at 45 °C and 13 MPa exhibited a contact angle of 142°, which was mainly caused by the multilevel micro- and nano- structure. The effects of polyethylene glycol(PEG), polyvinyl pyrrolidone(PVP) and lithium chloride(Li Cl) on the structures and crystal form were investigated. PVP promoted the formation of β phase crystal form, while PEG boosts the evolution of α phase. Li Cl restrained the crystallization degree of PVDF membrane under Sc CO2.