Identification of the involvement of LOXL4 in generation of keratocystic odontogenic tumors by RNA-Seq analysis

Keratocystic odontogenic tumors （KCOT） are benign, locally aggressive intraosseous tumors of odontogenic origin. KCOT have a higher stromal microvessel density （MVD） than dentigerous cysts （DC） and normal oral mucosa. To identify genes in the stroma of KCOT involved in tumor development and progression, RNA sequencing （RNA-Seq） was performed using samples from KCOT and primary stromal fibroblasts isolated from gingival tissues. Seven candidate genes that possess a function potentially related to KCOT progression were selected and their expression levels were confirmed by quantitative PCR, immunohistochemistry and enzyme-linked immunosorbent assay. Expression of lysyl oxidase-like 4 （LOXL4）, the only candidate gene that encodes a secreted protein, was enhanced at both the mRNA and protein levels in KCOT stromal tissues and primary KCOT stromal fibroblasts compared to control tissues and primary fibroblasts （P〈0.05）. In vitro, high expression of LOXL4 could enhance proliferation and migration of the human umbilical vein endothelial cells （HUVECs）. There was a significant, positive correlation between LOXL4 protein expression and MVD in stroma of KCOT and control tissues （r=0.882）. These data suggest that abnormal expression of LOXL4 of KCOT may enhance angiogenesis in KCOT, which may help to promote the locally aggressive biological behavior of KCOT.

Global trends and hot topics in clinical applications of perovskite materials:a bibliometric analysis

In recent years,perovskite has received increasing attention in the medical field.However,there has been a lack of related bibliometric analysis in this research field.This study aims to analyse the research status and hot topics of perovskite in the medical field from a bibliometric perspective and explore the research direction of perovskite.This study collected 1852 records of perovskite research in the medical field from 1983 to 2022 in the Web of Science(WOS)database.The country,institution,journal,cited references,and keywords were analysed using CiteSpace,VOS viewer,and Bibliometrix software.The number of articles related to perovskite research in the medical field has been increasing every year.China and USA have published the most papers and are the main forces in this research field.The University of London Imperial College of Science,Technology,and Medicine is the most active institution and has contributed the most publications.ACS Applied Materials&Interfaces is the most prolific journal in this field.“Medical electronic devices”,“X-rays”,and“piezoelectric materials”are the most researched directions of perovskite in the medical field.“Performance”,“perovskite”,and“solar cells”are the most frequently used keywords in this field.Advanced Materials is the most relevant and academically influential journal for perovskite research.Halide perovskites have been a hot topic in this field in recent years and will be a future research trend.X-ray,electronic medical equipment,and medical stents are the main research directions.

Synthesis and surface modification of cobalt nanoparticles and electromagnetic property of Co/PPy nanocomposites

In this work, cobalt nanoparticles were syn- thesized by chemical reduction procedure. After the hydrophilic functionalization, Co/polypyrrole （PPy） nanocomposites were prepared by in situ polymerization of pyrrole in aqueous dispersion of Co nanoparticles. The Co/ PPy nanocomposites show good electromagnetic properties with both magnetic loss and dielectric loss to electromag- netic wave. The electromagnetic wave absorbing band- width （reflection loss 〈-10 dB） for Co/PPy （20 wt%） is above 5.5 GHz at a thickness of 2 mm, and with a maximum reflection loss （around -20.02 dB） at 14.77 GHz. This magnetic nanoparticles/conducting polymer nanocomposites are great potential candidates for electromagnetic wave absorbent, because of their wide-absorbing frequency, strong absorption, good compatibility, low density, and controllable absorbing properties.