Neuroprotective effect of rapamycin on spinal cord injury via activation of the Wnt/β-catenin signaling pathway

The Wnt/β-catenin signaling pathway plays a crucial role in neural development, axonal guid- ance, neuropathic pain remission and neuronal survival. In this study, we initially examined the effect of rapamycin on the Wnt/β-catenin signaling pathway after spinal cord iniury, by intraperitoneally injecting spinal cord injured rats with rapamycin over 2 days. Western blot analysis and immunofluorescence staining were used to detect the expression levels of β-catenin protein, caspase-3 protein and brain-derived neurotrophic factor protein, components of the Wnt/β-catenin signaling pathway. Rapamycin increased the levels of β-catenin and brain-derived neurotrophic factor in the injured spinal cord, improved the pathological morphology at the injury site, reduced the loss of motor neurons, and promoted motor functional recovery in rats after spinal cord injury. Our experimental fndings suggest that the neuroprotective effect of rapamycin intervention is mediated through activation of the Wnt/β-catenin signaling pathway after spinal cord injury.

Effect of suspension training on neuromuscular function, postural control, and knee kinematics in anterior cruciate ligament reconstruction patients

BACKGROUND Suspension training(SET)is a method of neuromuscular training that enables the body to carry out active training under unstable support through a suspension therapy system.However,there have been few reports in the literature on the application of SET to anterior cruciate ligament reconstruction(ACLR)patients.It is not clear what aspects of the patient's function are improved after SET.AIM To investigate the effect of SET on the neuromuscular function,postural control,and knee kinematics of patients after ACLR surgery.METHODS Forty participants were randomized to an SET group or a control group.The SET group subjects participated in a SET protocol over 6 wk.The control group subjects participated in a traditional training protocol over 6 wk.Isokinetic muscle strength of the quadriceps and hamstrings,static and dynamic posture stability test,and relative translation of the injured knee were assessed before and after training.RESULTS The relative peak torque of the quadriceps and hamstrings in both groups increased significantly(P<0.001),and the SET group increased by a higher percentage than those in the control group(quadriceps:P=0.004;hamstrings:P=0.011).After training,both groups showed significant improvements in static and dynamic posture stability(P<0.01),and the SET group had a greater change than the control group(P<0.05).No significant improvement on the relative translation of the injured knee was observed after training in either group(P>0.05).CONCLUSION Our findings show that SET promotes great responses in quadriceps and hamstring muscle strength and balance function in ACLR patients.

Application of rare-earth element Y in refining impure copper

The effects of rare-earth element Y in refining impure copper were investigated in this paper. The composition, microstructures, and corrosion resistance properties of impure copper before and after refinement with Y were investigated using direct-reading spectrometry, inductively coupled plasma atomic emission spectrometry, optical microscopy, scanning electron microscopy, and potentiodynamic polariza- tion measurements. The results show that the concentrations of impurities S, As, Sb, Bi, A1, Cd, and Se are remarkably decreased. Adding an appropriate amount of Y refines the microstructure and enhances the corrosion resistance properties of impure copper in HC1 solution via a purification effect. The formation enthalpies of compounds formed between Y and various impurity elements were calculated on the basis of Miedema＇s theory. The thermodynamic mechanisms of the refinement of impure copper by Y were also discussed.

稀土铈对含铅杂铜显微组织和力学性能的影响

采用光学显微镜、扫描电镜、电子探针、透射电镜和拉伸实验研究稀土Ce对含Pb杂铜显微组织和力学性能的影响。透射电镜和能谱分析表明,Ce与Pb形成球状CePb3颗粒,粒径约3.6μm,均匀分布在铜基体中。CePb3与铜基体的错配度较低(约4.62%),可以作为有效成核质点,有利于晶粒细化。Pb存在于晶界会恶化铜的力学性能,Cu-0.1Pb的抗拉强度和伸长率分别比纯铜降低43.1%和56.7%。Ce加入能净化铜的晶界,形成CePb3第二相颗粒,细化晶粒尺寸,提高铜的力学性能。与Cu-0.1Pb相比,Cu-0.1Pb-0.3Ce的抗拉强度(179MPa)和伸长率(38.5%)分别提高117.6%和151.6%。

Microstructure and properties of TP2 copper tube with La microalloying by horizontal continuous casting

The TP2 copper tube was prepared with La microalloying by horizontal continuous casting(HCC). The absorptivity of La and its effects on microstructure, tensile and corrosion properties of HCC TP2 copper tube were studied by means of the inductively coupled plasma optical emission spectrometer(ICP-OES), optical microscope(OM), scanning electron microscope(SEM) and potentiodynamic polarization measurements. The results show that the absorptivity of La in the HCC TP2 copper tube is about 15% under antivacuum conditions due to the good chemical activities of La. The impurity elements in copper tube such as O, S, Pb and Si can be significantly reduced, and the average columnar dendrite spacing of the copper tube can also be reduced from 2.21 mm to 0.93 mm by adding La. The ultimate tensile strength and the elongation with and without La addition are almost unchanged. However, the annual corrosion rate of the HCC TP2 copper tube is reduced from 10.18 mm·a^(-1) to 9.37 mm·a^(-1) by the purification effect of trace La.

Evolution of Annealing Twins and Recrystallization Texture in Thin-Walled Copper Tube During Heat Treatment

Thin-walled copper tubes are usually produced by multi-pass float-plug drawing deformation.In general,the annealing treatment subsequently is necessary to release the stored energy and adjusts the microstructure.In this study,an investigation on the evolution of annealing twins as well as textures in the thin-walled(Φ6 mm×0.3 mm)copper tube underwent holding time-free heat treatment was reported.Electron backscattered diffraction analysis reveals that a large number ofΣ3 boundaries(600<111>twin relationship)are produced at the early stage of heat treatment,which is due to the lower boundary energy.With the recrystallization proceeding,the migration rate of grain boundaries decreases on account of the grain growth;meanwhile,the uniqueΣ9 boundaries(38.9°<110>relationship)are formed due to the interaction of theΣ3 boundaries.As a result,the number fractions ofΣ3 boundaries and high-angle grain boundaries decrease rapidly.During the grain growth stage,a strong recrystallization texture was formed due to the fact that the grains of Goss orientation have a growth advantage over the others.As a result,the initial copper texture was transferred into the Goss texture in domination.

Production of light-flavor and single-charmed hadrons in pp collisions at√s=5.02 TeV in an equal-velocity quark combination model

We apply an equal-velocity quark combination model to study the production of light-flavor hadrons and single-charmed hadrons at midrapidity in the pp collisions at √s= 5.02 TeV. We find that the experimental data for the pT spectra of Ω and φ exhibit the quark number scaling property, which clearly indicates the quark combination mechanism at hadronization. Experimental data for the pT spectra of p,Λ,Ξ,Ω,φ and K^(+0) are systematically described by the model. The non-monotonic pT dependence of the Ω/φ ratio is naturally explained, and we find that it is closely related to the shape of the logarithm of the strange quark pT distribution. Using the pT spectra of light-flavor quarks obtained from light-flavor hadrons and the pT spectrum of charm quarks, which is consistent with perturbative QCD calculations, the experimental data for differential cross-sections of D^(0,+), D^(+)_s), and Λ^(+)_(c) as functions of p are systematically described. We predict the differential cross-sections of Ξ^(0,+)_(c) and Ω^(0)_(c) . The ratio Ξ^(0,+)_(c) /D^0) in our model is approximately 0.16, and Ω^(0)_(c) /D^(0) is approximately 0.012, owing to the cascade suppression of strangeness.In addition, the predicted Ξ^(0,+)_(c) /D^0) ratios exhibit the non-monotonic dependence on pT in the low pT range.

Constituent quark number scaling from strange hadron spectra in pp collisions at ■=13 TeV

We show that the p_T spectra ofΩ^-andφat midrapidity in the inelastic events in pp collisions at■=13 TeV exhibit a constituent quark number scaling property,which is a clear signal of quark combination mechanism at hadronization.We use a quark combination model with equal velocity combination approximation to systematically study the production of identified hadrons in pp collisions at■=13 TeV.The midrapidity spectra for protons,∧,Ξ^-,Ω^-,φand K~*in the inelastic events are simultaneously fitted by the model.The multiplicity dependence of the yields of these hadrons are also well understood.The strong p_T dependence of the p/φratio is well explained by the model,which further suggests that the production of two hadrons with similar masses is determined by their quark content at hadronization.The p_T spectra of strange hadrons at midrapidity in different multiplicity classes in pp collisions at■=13 TeV are predicted for further tests of the model.The midrapidity p_T spectra of soft(p_T<2 GeV/c)strange quarks and up/down quarks at hadronization in pp collisions at■=13 TeV are extracted.

细菌降解蒽醌染料研究进展（英文）

本文综述了近年来细菌降解蒽醌染料的研究进展及机理,以期为蒽醌染料废水的实际处理提供理论依据。目前主要利用物理、化学及生物法处理工业印染废水中的各种染料。与前两者相比,生物法具有经济且环保的特点。本文以蒽醌染料的分类及结构为基础,总结近年来已报道的蒽醌染料高效降解细菌的多样性;初步探讨细菌吸附、降解蒽醌染料的机理与主要影响因素;根据目前的研究进展及存在问题,提出细菌降解蒽醌染料的研究方向。

Chimera states in bipartite networks of FitzHugh-Nagumo oscillators

Chimera states consisting of spatially coherent and incoherent domains have been observed in differ- ent topologies such as rings, spheres, and complex networks. In this paper, we investigate bipartite networks of nonlocally coupled FitzHugh-Nagumo （FHN） oscillators in which the units are allocated evenly to two layers, and FHN units interact with each other only when they are in different lay- ers. We report the existence of chimera states in bipartite networks. Owing to the interplay between chimera states in the two layers, many types of chimera states such as in-phase chimera states, an- tiphase chimera states, and out-of-phase chimera states are classified. Stability diagrams of several typical chimera states in the coupling strength-coupling radius plane, which show strong multistability of chimera states, are explored.

Chimera dynamics in nonlocally coupled moving phase oscillators

Chimera states,a symmetry-breaking spatiotemporal pattern in nonlocally coupled dynamical units,prevail in a variety of systems.However,the interaction structures among oscillators are static in most of studies on chimera state.In this work,we consider a population of agents.Each agent carries a phase oscillator.We assume that agents perform Brownian motions on a ring and interact with each other with a kernel function dependent on the distance between them.When agents are motionless,the model allows for several dynamical states including two different chimera states (the type-Ⅰ and the type-Ⅱ chimeras).The movement of agents changes the relative positions among them and produces perpetual noise to impact on the model dynamics.We find that the response of the coupled phase oscillators to the movement of agents depends on both the phase lag α,determining the stabilities of chimera states,and the agent mobility D.For low mobility,the synchronous state transits to the type-Ⅰ chimera state for α close to π/2 and attracts other initial states otherwise.For intermediate mobility,the coupled oscillators randomly jump among different dynamical states and the jump dynamics depends on α.We investigate the statistical properties in these different dynamical regimes and present the scaling laws between the transient time and the mobility for low mobility and relations between the mean lifetimes of different dynamical states and the mobility for intermediate mobility.

Differential Innervation of Secretory Coils and Ducts in Human Eccrine Sweat Glands

Background： Previous studies demonstrate that eccrine sweat glands are innervated by both cholinergic and adrenergic nerves. However, it is still unknown whether the secretory coils and ducts ofeccrine sweat glands are equally innervated by the sympathetic nerve fibers. To welt understand the mechanisms on sweat secretion and reabsorption, the differential innervation of secretory coils and ducts in human eccrine sweat glands was investigated in the study. Methods： From June 2016 to June 2017, six human skins were fixed, paraffin-embedded, and cut into 5 μm-thick sections, followed by costaining for nerve fiber markers protein gene product 9.5 （PGP 9.5）, tyrosine hydroxylase （TH） and vasoactive intestinal peptide （VIP）, and eccrine sweat gland markers K7, S100P, and K14 by combining standard immunofluorescence with tyramide signal amplification （IF-TSA）. Stained sections were observed under the microscope, photographed, and analyzed. Results： The fluorescent signals of PGP 9.5, TH, and VIP were easily visualized, by 1F-TSA, as circular patterns surrounding eccrine sweat glands, but only PGP 9.5 could be observed by standard IF. The IF-TSA method is more sensitivity than standard IF in detecting antigens expressed at low levels. PGP 9.5, TH, and VIP appeared primarily surrounding the secretory coils and sparsely surrounding the sweat ducts. Conclusion： Sweat secretion is mainly controlled by autonomic nerves whereas sweat reabsorption is less affected by nerve activity.

Entangled chimeras in nonlocally coupled bicomponent phase oscillators:From synchronous to asynchronous chimeras

Chimera states,a symmetry-breaking spatiotemporal pattern in nonlocally coupled identical dynamical units,have been identified in various systems and generalized to coupled nonidentical oscillators.It has been shown that strong heterogeneity in the frequencies of nonidentical oscillators might be harmful to chimera states.In this work,we consider a ring of nonlocally coupled bicomponent phase oscillators in which two types of oscillators are randomly distributed along the ring:some oscillators with natural.frequency w1 and others with w2.In this model,the heterogeneity in frequency is measured by frequency mismatch|w1-w2|between the oscillators in these two subpopulations.We report that the nonlocally coupled bicomponent phase oscillators allow for chimera states no matter how large the frequency mismatch is.The bicomponent oscillators are composed of two chimera states,one supported by oscillators with natural frequency wI and the other by oscillators with natural frequency w2.The two chimera states in two subpopulations are synchronized at weak frequency mismatch,in which the coberent oscillators in thern share similar mean phase velocity,and are desynchronized at large frequency mismatch,in which the coherent oscillators in different subpopulations have distinct mean phase velocities.The synchronization-desynchronization transition between chimera states in these two subpopulations is observed with the increase in the frequency mismatch.The observed phenomena are theoretically analyzed by passing to the continuum limit and using the Ott-Antonsen approach.