Comprehensive Summary The first catalytic asymmetric total synthesis of(+)-propolisbenzofuran B,enabled by a highly enantioselective rhodium-catalyzed hydrogenation of a tetrasubstituted olefin,was described.Other not...Comprehensive Summary The first catalytic asymmetric total synthesis of(+)-propolisbenzofuran B,enabled by a highly enantioselective rhodium-catalyzed hydrogenation of a tetrasubstituted olefin,was described.Other noteworthy aspects include the construction of the central hydrodibenzo[b,d]furan core through a sequence of Zn(II)-mediated regioselective benzofuran formation and Dieckmann condensation,as well as C-H oxidations,involving a visible light-induced Fe(III)-catalyzed benzylic C(sp3)-H oxidation.Additionally,the absolute configuration was confirmed by X-ray analysis of a carbonate intermediate.展开更多
基金the National Natural Science Foundation of China(No.22271236)for support of this research.
文摘Comprehensive Summary The first catalytic asymmetric total synthesis of(+)-propolisbenzofuran B,enabled by a highly enantioselective rhodium-catalyzed hydrogenation of a tetrasubstituted olefin,was described.Other noteworthy aspects include the construction of the central hydrodibenzo[b,d]furan core through a sequence of Zn(II)-mediated regioselective benzofuran formation and Dieckmann condensation,as well as C-H oxidations,involving a visible light-induced Fe(III)-catalyzed benzylic C(sp3)-H oxidation.Additionally,the absolute configuration was confirmed by X-ray analysis of a carbonate intermediate.
