In order to discover new generation of triazole antifungal agents,a series of novel antifungal triazoles were designed and synthesized by structural simplification of our previously identified triazolepiperdine-hetero...In order to discover new generation of triazole antifungal agents,a series of novel antifungal triazoles were designed and synthesized by structural simplification of our previously identified triazolepiperdine-heterocycle lead compounds.Several target compounds showed good antifungal activity with a broad spectrum.In particular,compound 71 was highly active against Candida albicans and Candida glabrata.Moreover,compound 71 showed potent in vivo antifungal efficacy in the Caenorhabditis elegans-C.albicans infection model.展开更多
基金supported by the National Natural Science Foundation of China(Nos.81573283,21502224)the 863 Hi-Tech Program of China(No.2014AA020525)the Shanghai"ShuGuang"Project(No.14SG33)
文摘In order to discover new generation of triazole antifungal agents,a series of novel antifungal triazoles were designed and synthesized by structural simplification of our previously identified triazolepiperdine-heterocycle lead compounds.Several target compounds showed good antifungal activity with a broad spectrum.In particular,compound 71 was highly active against Candida albicans and Candida glabrata.Moreover,compound 71 showed potent in vivo antifungal efficacy in the Caenorhabditis elegans-C.albicans infection model.
