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Development and validation of a model to determine risk of refractory benign esophageal strictures 被引量:1
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作者 Qing Lu Tian-Tian Lei +5 位作者 Yi-Lan Wang hai-lin yan Bo Lin Lin-Lin Zhu Hong-Sheng Ma Jin-Lin yang 《World Journal of Clinical Cases》 SCIE 2019年第13期1623-1633,共11页
BACKGROUND Current research has identified several risk factors for refractory benign esophageal strictures (RBES), but research is scarce on the prediction of RBES in benign esophageal strictures patients. Meanwhile,... BACKGROUND Current research has identified several risk factors for refractory benign esophageal strictures (RBES), but research is scarce on the prediction of RBES in benign esophageal strictures patients. Meanwhile, the long-term outcomes of RBES remain unclear. The aim of this study was to develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures. And we also explored the long-term outcomes and safety in patients with RBES. AIM To develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures, based on the demographic data and endoscopic findings. METHODS A total of 507 benign esophageal stricture patients treated by dilation alone or in combination with stenting were retrospectively enrolled between January 2009 and February 2018. The primary outcome was to establish a risk-scoring model predicting RBES in benign esophageal strictures. The secondary outcome was to explore the clinical effectiveness and adverse events in patients with RBES. RESULTS In the study, age, etiology, and number and length of strictures were the independent risk factors for the refractory performance of benign esophageal strictures. According to risk factors of benign esophageal strictures, a risk-scoring model for predicting RBES in benign esophageal strictures was established: The risk score ranged from 0 to 8 points, and the risk scores were divided into low risk (0-2 points), intermediate risk (3-5 points), and high risk (6-8 points). The proportions of RBES in the corresponding risk categories were 1.0%, 12.2%, and 76.0%, respectively. Among 507 patients, 57 had RBES (39 males;median age, 60 years). The success rate of dilation treatment (51.2%, 21/41) was higher than that of stent placement (37.5%, 6/16). CONCLUSION In this study, 11.3%(57/507) patients had RBES at our hospital. The risk-scoring model predicting RBES in benign esophageal strictures could predict the longterm outcome of patients with strictures ahead. 展开更多
关键词 REFRACTORY BENIGN ESOPHAGEAL STRICTURES ESOPHAGEAL DILATION ESOPHAGEAL STENTS Long-term outcomes Retrospective analysis
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梨火疫菌Sec依赖分泌蛋白酶的全基因组鉴定及其在侵染幼梨过程中的基因表达分析 被引量:3
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作者 Wang-bin ZHANG hai-lin yan +4 位作者 Zong-cai ZHU Chao ZHANG Pei-xiu DU Wen-jun ZHAO Wei-min LI 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2020年第9期716-726,共11页
目的:鉴定参与梨火疫菌侵染的重要Sec依赖分泌蛋白酶。创新点:构建了梨火疫菌Sec依赖分泌蛋白酶编码基因在侵染寄主植物过程中的时序表达图谱。方法:利用生物信息学与大肠杆菌Pho A检测体系两者结合,在全基因组水平筛选并鉴定梨火疫菌的... 目的:鉴定参与梨火疫菌侵染的重要Sec依赖分泌蛋白酶。创新点:构建了梨火疫菌Sec依赖分泌蛋白酶编码基因在侵染寄主植物过程中的时序表达图谱。方法:利用生物信息学与大肠杆菌Pho A检测体系两者结合,在全基因组水平筛选并鉴定梨火疫菌的Sec依赖分泌蛋白酶;利用逆转录实时定量聚合酶链反应(RT-q PCR),分析Sec依赖分泌蛋白酶编码基因在梨火疫菌侵染寄主植物过程中转录表达的时序变化。结论:梨火疫菌含有完整的Sec分泌系统,可由此分泌至少15种蛋白酶,其中11种蛋白酶可能在病原菌侵染寄主植物过程中发挥功能。 展开更多
关键词 梨火疫菌 Sec依赖分泌系统 蛋白酶 基因表达 侵染
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胆囊出血合并胆囊结肠瘘:一例报告 被引量:1
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作者 hai-lin yan Bo Lin +3 位作者 Qing Lu Tian-Tian Lei Hong-Sheng Ma Jin-Lin yang 《Gastroenterology Report》 SCIE EI 2021年第1期81-84,I0003,共5页
Introduction Gallstone disease is a major public-health problem,with a high prevalence ranging from 10%to 15%[1].Acute cholecystitis,chronic cholecystitis,choledocholithiasis,and gallstone pancreatitis are all common ... Introduction Gallstone disease is a major public-health problem,with a high prevalence ranging from 10%to 15%[1].Acute cholecystitis,chronic cholecystitis,choledocholithiasis,and gallstone pancreatitis are all common complications in clinical practice.However,when gallstones migrate to adjacent viscera or vascular structures,the clinical challenge is far less familiar[2].Gallbladder(GB)bleeding is seldom reported,which mostly manifests as hemobilia.Some cases are caused by cystic artery aneurysm and rupture and others are due to GB rupture[3].Gallstones can erode through the gallbladder wall or bile duct into the adjacent portion,resulting in a cholecystocolonic fistula(CCF),which is a rare complication of gallstones with cholecystitis[4].Here,we share a case of gallbladder bleeding along with cholecystocolonic fistula that has not yet been reported.We hope that,through our unusual case,clinicians gain an enhanced understanding of rare complications caused by gallstones. 展开更多
关键词 CHOLECYSTITIS RUPTURE BLEEDING
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