Value of serum hk10 and DJ-1 levels in patients with ovarian cancer for evaluating the malignant biology of tumor

Objective:To discuss the value of serum hk10 and DJ-1 levels in patients with ovarian cancer for evaluating the malignant biology of tumor.Methods:A total of80 patients with ovarian cancer who underwent surgical treatment in our hospital between August 2015 and February 2018 were selected as ovarian cancer group, and 67 patients with ovarian cyst were selected as ovarian cyst group. The differences in the levels of hk10 and DJ-1 in preoperative serum as well as the expression of ovarian cancer-related proliferation genes and invasion genes in intraoperative lesion tissue were compared between the two groups. Correlation analysis was used to assess the inner link of serum hk10 and DJ-1 levels with tumor malignancy in patients with ovarian cancer.Results: Serum hk10 and DJ-1 levels of ovarian cancer group were higher than those of ovarian cyst group;proliferation genes Clusterin, FUNDC1, AKT, TNFAIP8 and HBXIP mRNA expression in lesion tissues were higher than those of ovarian cyst group;invasion genes Beclin1, BRMS1 and SIRT2 mRNA expression in lesion tissues were lower than those of ovarian cyst group whereas EFEMP1 mRNA expression was higher than that of ovarian cyst group. The Pearson test showed that serum hk10 and DJ-1 levels in ovarian cancer were directly correlated with the expression of proliferation genes and invasion genes. Conclusion: hk10 and DJ-1 are highly expressed in serum of patients with ovarian cancer, and their levels are directly correlated with the proliferation and invasion activity of cancer cells.

Exact relations for two-photon-exchange effect in elastic ep scattering by dispersion relation and hadronic model

The two-photon-exchange(TPE)effect plays a key role in extracting the form factors(FFs)of the proton.In this work,we discuss several exact properties of the TPE effect in the elastic ep scattering.By taking four low energy interactions as examples,we analyze kinematical singularities,asymptotic behaviors,and branch cuts of TPE amplitudes.The analytical expressions clearly indicate several exact relations between the dispersion relation(DR)and hadronic model(HM)methods.This suggests that the two methods must be modified to general forms,while novel forms yield the same results.After the modification,new DRs include a non-trivial term with two singularities.Furthermore,new DRs automatically include contributions due to the seagull interaction,meson-exchange effect,contact interactions,and off-shell effect.To analyze the elastic e^(±)}p scattering data sets,the new forms must be used.