Objective： To investigate the recurrent patterns and factors involved in node-negative advanced gastric cancer after curative resection. Patients and Methods： Clinicopathological characteristics and prognostic outco...Objective： To investigate the recurrent patterns and factors involved in node-negative advanced gastric cancer after curative resection. Patients and Methods： Clinicopathological characteristics and prognostic outcomes of 310 patients who had lymph node-negative advanced gastric adenocarcinoma and received curative resection between 2002 and 2006 were retrospectively evaluated. Results： Among the 300 patients, 15 （5.0%） had locoregional recurrence, 5 （1.7%） had lymph node recurrence, 27 （9.0%） had peritoneal seeding recurrence, and 21 （7.0%） had hematogenous metastasis. Using multivariate analysis, we found that the maximum tumor diameter （P=0.014）, histological type （P=0.001） and Borrmann type （P=0.033） were independent factors predicting the locoregional recurrence. Lymph node recurrence was significantly affected by lymph node dissection （P=0.029） and lymphovascular invasion （P=0.004）. Clinicopathological factors predicting the peritoneal seeding recurrence were the depth of invasion （P=0.001） and Borrmann type （P=0.002）. In addition, lymphovascular invasion （P=0.013） and histological type （P=0.001） were significantly associated with hematogenous metastasis. Conclusion： Node-negative advanced gastric cancer has a high amount of peritoneal seeding and hematogenous metastasis.展开更多
Objective：Laryngeal squamous cell carcinoma（LSCC） is a common malignant tumor in Northeast China and is frequently associated with well-established risk factors like smoking and alcohol abuse.Human papilloma virus...Objective：Laryngeal squamous cell carcinoma（LSCC） is a common malignant tumor in Northeast China and is frequently associated with well-established risk factors like smoking and alcohol abuse.Human papilloma virus（HPV） is an epitheliotropic oncogenic virus that has been detected in a variety of head and neck tumors including LSCC.This retrospective study was to investigate the prevalence of HPV infection in patients with LSCC.Methods：In situ hybridization was performed in 99 patients with LSCC to detect the expression of HPV-16 E6 mRNA.Results：The positive rate of HPV16 E6 mRNA was 36.36%（36/99） in laryngeal squamous cell carcinoma（LSCC）,whereas only 3 of 50（6%） specimens of the normal laryngeal mucosa as a control group showed positive results（P0.05）.Additionally,there was no corelation between HPV16 and age,gender,clinical stage,nodal status and tumor site（P0.05）.Conclusion：The results suggest that the increased prevalence of HPV infection compared to normal laryngeal mucosa and the fact that high-risk HPV types（especially type 16） were the most frequently identified do not allow the exclusion of HPV as a risk factor in laryngeal squamous cell carcinoma.However,their clinical value remains to be further investigated.展开更多
文摘Objective： To investigate the recurrent patterns and factors involved in node-negative advanced gastric cancer after curative resection. Patients and Methods： Clinicopathological characteristics and prognostic outcomes of 310 patients who had lymph node-negative advanced gastric adenocarcinoma and received curative resection between 2002 and 2006 were retrospectively evaluated. Results： Among the 300 patients, 15 （5.0%） had locoregional recurrence, 5 （1.7%） had lymph node recurrence, 27 （9.0%） had peritoneal seeding recurrence, and 21 （7.0%） had hematogenous metastasis. Using multivariate analysis, we found that the maximum tumor diameter （P=0.014）, histological type （P=0.001） and Borrmann type （P=0.033） were independent factors predicting the locoregional recurrence. Lymph node recurrence was significantly affected by lymph node dissection （P=0.029） and lymphovascular invasion （P=0.004）. Clinicopathological factors predicting the peritoneal seeding recurrence were the depth of invasion （P=0.001） and Borrmann type （P=0.002）. In addition, lymphovascular invasion （P=0.013） and histological type （P=0.001） were significantly associated with hematogenous metastasis. Conclusion： Node-negative advanced gastric cancer has a high amount of peritoneal seeding and hematogenous metastasis.
文摘Objective：Laryngeal squamous cell carcinoma（LSCC） is a common malignant tumor in Northeast China and is frequently associated with well-established risk factors like smoking and alcohol abuse.Human papilloma virus（HPV） is an epitheliotropic oncogenic virus that has been detected in a variety of head and neck tumors including LSCC.This retrospective study was to investigate the prevalence of HPV infection in patients with LSCC.Methods：In situ hybridization was performed in 99 patients with LSCC to detect the expression of HPV-16 E6 mRNA.Results：The positive rate of HPV16 E6 mRNA was 36.36%（36/99） in laryngeal squamous cell carcinoma（LSCC）,whereas only 3 of 50（6%） specimens of the normal laryngeal mucosa as a control group showed positive results（P0.05）.Additionally,there was no corelation between HPV16 and age,gender,clinical stage,nodal status and tumor site（P0.05）.Conclusion：The results suggest that the increased prevalence of HPV infection compared to normal laryngeal mucosa and the fact that high-risk HPV types（especially type 16） were the most frequently identified do not allow the exclusion of HPV as a risk factor in laryngeal squamous cell carcinoma.However,their clinical value remains to be further investigated.
