The combination of levofloxacin and a1 adrenergic antagonist treatment is the current preferred choice for both bacterial and non-bacterial prostatitis. The aim of this study is to explore the influence of a1 adrenerg...The combination of levofloxacin and a1 adrenergic antagonist treatment is the current preferred choice for both bacterial and non-bacterial prostatitis. The aim of this study is to explore the influence of a1 adrenergic antagonists on the pharmacokinetics of levofloxacin using rat models with acute bacterial prostatitis （ABP） induced by direct injection with Escherichia coil （ATCC25922）, A total of 96 model rats were randomly assigned into two groups： the experimental group （treated with both tamsulosin and levofloxacin, n=48） and the control group （treated with levofloxacin and solvents, n=48）. Six rats from each group were euthanized to collect blood, liver, kidney and prostate samples at the time points of 0. 125, 0.25, 0.5, 1,2, 4, 8 and 12 h after drug administration. The levofloxacin concentrations were detected by high performance liquid chromatography （HPLC）, and the pharmacokinetic parameters were calculated using the 3p97 software program. There were no obvious differences （P〉0.05） between the experimental and control groups in the major pharmacokinetic parameters of levofloxacin, including the halftime （t1/2）, time to peak （tpeak）, clearance rate （CL）, maximum concentration （Cmax） and area under the curve （AUC0-12）, in the plasma or in the hepatic and kidney tissues of the model rats. However, in the prostatic tissues, tamsulosin increased the Cmax, prolonged the t1/2 and decreased the CL of levofloxacin （P〈0.05）. These results indicate that tamsulosin may enhance the effect of levofloxacin in the treatment of bacterial prostatitis without changing the drug concentration in the liver and kidney.展开更多
This paper reviews the asthenia´s occurrence status,adverse outcomes and assessment tools of patients with chronic obstructive pulmonary disease,as well as safety management strategies such as preventing or impro...This paper reviews the asthenia´s occurrence status,adverse outcomes and assessment tools of patients with chronic obstructive pulmonary disease,as well as safety management strategies such as preventing or improving pulmonary rehabilitation and nutritional therapy in patients with asthenia´s.It can provide reference for clinical nurses or researchers to find or develop assessment tool asthenia suitable for domestic patients with chronic obstructive pulmonary disease and set down intervention measurements.展开更多
文摘The combination of levofloxacin and a1 adrenergic antagonist treatment is the current preferred choice for both bacterial and non-bacterial prostatitis. The aim of this study is to explore the influence of a1 adrenergic antagonists on the pharmacokinetics of levofloxacin using rat models with acute bacterial prostatitis （ABP） induced by direct injection with Escherichia coil （ATCC25922）, A total of 96 model rats were randomly assigned into two groups： the experimental group （treated with both tamsulosin and levofloxacin, n=48） and the control group （treated with levofloxacin and solvents, n=48）. Six rats from each group were euthanized to collect blood, liver, kidney and prostate samples at the time points of 0. 125, 0.25, 0.5, 1,2, 4, 8 and 12 h after drug administration. The levofloxacin concentrations were detected by high performance liquid chromatography （HPLC）, and the pharmacokinetic parameters were calculated using the 3p97 software program. There were no obvious differences （P〉0.05） between the experimental and control groups in the major pharmacokinetic parameters of levofloxacin, including the halftime （t1/2）, time to peak （tpeak）, clearance rate （CL）, maximum concentration （Cmax） and area under the curve （AUC0-12）, in the plasma or in the hepatic and kidney tissues of the model rats. However, in the prostatic tissues, tamsulosin increased the Cmax, prolonged the t1/2 and decreased the CL of levofloxacin （P〈0.05）. These results indicate that tamsulosin may enhance the effect of levofloxacin in the treatment of bacterial prostatitis without changing the drug concentration in the liver and kidney.
基金Natural Science Foundation of Hainan Department of Science and Technology high-level Talents Project(No.2019RC232)Hainan Provincial Department of Education Scientific Research Project(No.Knky2018ZD-9)。
文摘This paper reviews the asthenia´s occurrence status,adverse outcomes and assessment tools of patients with chronic obstructive pulmonary disease,as well as safety management strategies such as preventing or improving pulmonary rehabilitation and nutritional therapy in patients with asthenia´s.It can provide reference for clinical nurses or researchers to find or develop assessment tool asthenia suitable for domestic patients with chronic obstructive pulmonary disease and set down intervention measurements.
