偏好食物刺激联合口香糖咀嚼与下肢功能锻炼操优化妇科腹腔镜手术患者术后胃肠功能的效果观察

目的探究偏好食物刺激联合口香糖咀嚼与下肢功能锻炼操对妇科腹腔镜手术患者术后胃肠功能的影响。方法按随机数表法将患者分为食物刺激联合口香糖咀嚼与下肢锻炼组(FCL组)和口香糖咀嚼与下肢锻炼组(CL组),每组60例。患者均行妇科腹腔镜手术,FCL组在术后采用食物刺激联合口香糖咀嚼与下肢锻炼法改善胃肠功能,CL组在术后采用口香糖咀嚼与下肢锻炼法改善胃肠功能。比较两组患者血浆胃泌素水平、第一次排气及排便时间、数字分级评分法(NRS)、不良反应发生情况的差异性。结果手术后72 h,FCL组血浆胃泌素水平为(350.75±27.46)pmol/L,明显高于CL组的(269.63±14.96)pmol/L(P<0.05);CL组第一次排气及排便时间为(25.56±2.46)和(48.74±5.97)h,FCL组为(16.74±2.01)和(34.95±4.92)h,FCL组明显短于CL组(P<0.05);手术后24 h,CL组NRS评分为(5.83±1.46)分,FCL组为(3.17±1.02)分,手术后72 h,CL组NRS评分为(4.74±1.75)分,FCL组为(2.13±0.89)分,FCL组明显低于CL组(P<0.05);FCL组不良反应情况发生率为6.67%,明显低于CL组的25.00%(P<0.05)。结论偏好食物刺激联合口香糖咀嚼与下肢功能锻炼对妇科腹腔镜手术患者术后胃肠功能的改善效果明显优于口香糖咀嚼与下肢功能锻炼。

Synthesis and BK channel-opening activity of novel N-acylhydrazone derivatives from dehydroabietic acid

A series of hydrazone and N-acylhydrazone derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKa channels.The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at hydrazone moiety.