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早期食管基底细胞样鳞状细胞癌的内镜特征及预后分析
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作者 庄惠军 陈进忠 +9 位作者 苏虹 王海星 雷天霞 吴建海 杨炜琳 郑永胜 陈金海 许国幸 张宏斌 谢逸林 《中国内镜杂志》 2023年第3期50-55,共6页
目的研究早期食管基底细胞样鳞状细胞癌(EBSCC)的内镜特征、治疗效果及预后。方法回顾性分析2014年1月-2020年12月该院发现并行ESD治疗的早期EBSCC患者32例(EBSCC组),纳入同期行内镜黏膜下剥离术(ESD)治疗的普通典型早期食管鳞状细胞癌(... 目的研究早期食管基底细胞样鳞状细胞癌(EBSCC)的内镜特征、治疗效果及预后。方法回顾性分析2014年1月-2020年12月该院发现并行ESD治疗的早期EBSCC患者32例(EBSCC组),纳入同期行内镜黏膜下剥离术(ESD)治疗的普通典型早期食管鳞状细胞癌(ESCC)患者96例作为对照组(ESCC组),对比分析两组患者年龄、性别、肿瘤大小、肿瘤浸润深度、内镜特征、治疗结果及生存率等。结果两组患者发病年龄(P=0.746)、性别(P=0.506)、肿瘤大小(P=0.423)和肿瘤浸润深度(P=0.914)比较,差异均无统计学意义。两组患者肿瘤均好发于食管中段,内镜下分型以0-Ⅱb型为主,所有病灶表面黏膜均粗糙和/或糜烂,放大内镜观察上皮内乳头状毛细血管袢(IPCL),以B1型为主,两组患者比较,差异无统计学意义(P>0.05)。EBSCC组较ESCC组病灶表面白斑出现的概率更高,差异有统计学意义(56.25%和26.04%,χ^(2)=9.88,P=0.002)。碘液染色:EBSCC组有17例(53.12%)为不染或淡染,15例(46.88%)有斑驳状不染改变(即碘不染区域中可见岛状染色斑点或者深染斑点);ESCC组有72例(75.00%)为不染或淡染,24例(25.00%)有斑驳状不染改变,两组患者碘液染色后改变比较,差异有统计学意义(χ^(2)=5.42,P=0.020)。两组患者治疗后生存率比较,差异无统计学意义(93.75%和96.88%,χ^(2)=0.62,P=0.429)。结论早期EBSCC内镜下表现不一致,病灶表面白斑、碘液染色后呈斑驳状不染改变和放大内镜结合窄带成像技术观察到B型血管,提示可能存在基底细胞样鳞状细胞癌(BSCC)成分。早期治疗EBSCC可提高患者生存率,改善预后。 展开更多
关键词 食管基底细胞样鳞状细胞癌 内镜特征 早期治疗 生存率 内镜黏膜下剥离术
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Aerodynamics of indirect thrust measurement by the impulse method 被引量:10
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作者 Cheng-Kang Wu hai-xing wang +2 位作者 Xian Meng Xi Chen Wen-Xia Pan 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2011年第2期152-163,共12页
The aerodynamic aspects of indirect thrust measurement by the impulse method have been studied both experimentally and numerically. The underlying basic aerodynamic principle is outlined, the phenomena in subsonic, su... The aerodynamic aspects of indirect thrust measurement by the impulse method have been studied both experimentally and numerically. The underlying basic aerodynamic principle is outlined, the phenomena in subsonic, supersonic and arc-heated jets are explored, and factors affecting the accuracy of the method are studied and discussed. Results show that the impulse method is reliable for indirect thrust measurement if certain basic requirements are met, and a simple guideline for its proper application is given. 展开更多
关键词 Thrust measurement Impulse method Aerodynamic features Cold jet Arc-heated jet
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Mechanisms for non-ideal flow in low-power arc-heated supersonic nozzles 被引量:1
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作者 Cheng-Kang Wu Wen-Xia Pan +1 位作者 Xian Meng hai-xing wang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2015年第4期500-511,共12页
The flow in a low-powered arc gas heater com- bined with a supersonic nozzle of throat diameter less than 1 mm is quite complicated and difficult to describe in quan- titative detail. Experiments on arc-heated superso... The flow in a low-powered arc gas heater com- bined with a supersonic nozzle of throat diameter less than 1 mm is quite complicated and difficult to describe in quan- titative detail. Experiments on arc-heated supersonic jet thrusters of monatomic gases argon and helium have been carried out and their performance measured. The flow charac- teristics are analyzed with the help of numerical simulation. Results show that the viscous effect is the most important factor causing the large difference between ideal and real performance. A large outer section of the exit flow is slow- moving. This is especially pronounced in helium, where 70 % of the exit area of the nozzle might be in subsonic flow. Fric- tion forces can be much larger than the net thrust, reaching several times higher in helium, resulting in very low efficien- cies. Other factors causing the differences between ideal and real flow include: complex flow in the throat region, electric arc extending to the nozzle expansion section, heat transfer to the inlet gas and from the hot plasma, and environmen- tal pressure in the vacuum chamber. It is recognized that the ordinary concepts of supersonic nozzle flow must be greatly modified when dealing with such complicated situations. The general concepts presented in this paper could be helpful in guiding the design and operation of this equipment. 展开更多
关键词 Arc-heated supersonic jet LOW-POWER Real flow Viscosity effect Low Reynolds number
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东南景天叶肉细胞原生质体和液泡的分离与纯化技术(英文) 被引量:1
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作者 Xiao-yu GAO Xing-cheng LIAO +3 位作者 Ruo-lai WU Ting LIU hai-xing wang Ling-li LU 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2017年第1期85-88,共4页
目的:在超积累植物东南景天对镉的区隔化过程中,叶肉细胞等内含大型液泡的薄壁细胞起重要作用。本文旨在建立并优化其叶肉细胞原生质体和液泡的提取和纯化技术,在技术层面上为东南景天的镉区隔化机理研究奠定基础,有助于深入探明其超积... 目的:在超积累植物东南景天对镉的区隔化过程中,叶肉细胞等内含大型液泡的薄壁细胞起重要作用。本文旨在建立并优化其叶肉细胞原生质体和液泡的提取和纯化技术,在技术层面上为东南景天的镉区隔化机理研究奠定基础,有助于深入探明其超积累镉的生理与分子机理。创新点:优化了东南景天叶片原生质体的提取和纯化技术,并建立了能较高效率获得膜完整性好、数量多、纯度高的液泡提取方法。方法:主要包括原生质体提取、液泡粗提和液泡纯化。原生质体提取:取东南景天叶片,切成1~2 mm的细条状后浸入经预热过的细胞裂解液中,震荡2 h后过滤,离心清洗后获得原生质体。液泡粗提:采用1-丙磺酸浓度为0.675 mmol/L的原生质体裂解液裂解原生质体,离心后获得粗提的液泡,并加入含0.8 mol/L甘露醇的液泡保护液。液泡纯化:往初提液泡的悬浮液下层加入质量体积比浓度为0.10 g/ml的Ficoll溶液,进行密度梯度离心,获取纯化的液泡。结论:细胞裂解液的预热处理可加速细胞壁降解,裂解时间设置为2 h有利于原生质体的高效提取;通过对原生质体裂解液浓度、细胞保护液浓度和梯度离心等参数的改良,可有效提取叶片细胞原生质体中的液泡。 展开更多
关键词 超积累植物 东南景天 原生质体 液泡 提取与纯化
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