Al_(2)O_(3)插入层对HfO_(2)/ZrO_(2)叠层薄膜铁电性能的影响

基于优良的可扩展性和良好的互补金属氧化物半导体工艺兼容性,铁电HfO_(2)基非易失性存储器引发广泛的研究兴趣。采用原子层沉积方法制备(HfO_(2)-ZrO_(2))_(3)/mAl_(2)O_(3)/(HfO_(2)-ZrO_(2))_(3)纳米叠层薄膜(m为Al_(2)O_(3)厚度),并通过改变Al_(2)O_(3)厚度研究其铁电性和可靠性。结果表明,当m为1mm时,叠层薄膜表现出最高的剩余极化值,为23.87μC/cm^(2),且随着Al_(2)O_(3)厚度的增加,漏电流值可降低2-3个数量级。Al_(2)O_(3)和HfO_(2)-ZrO_(2)因介电错配而产生界面极化,同时更低介电常数的Al_(2)O_(3)可有效调控叠层薄膜内部的电场分布,从而促进铁电性能和可靠性的协同提升,这为更宽厚度范围HfO_(2)基铁电存储器件的设计提供新的思路。

Giant juvenile fibroadenoma in a 14-year old Chinese female:A case report

BACKGROUND A giant juvenile fibroadenoma(GJF)is a rare,benign breast tumor that affects females<18 years of age.GJFs are generally suspected based on a palpable mass.GJFs influence breast shape and mammary gland development via the pressure effect from their enormous size.CASE SUMMARY Herein we report a case involving a 14-year-old Chinese female with a GJF in the left breast.GJF is a rare,benign breast tumor that usually occurs between 9 and 18 years of age and accounts for 0.5%-4.0%of all fibroadenomas.In severe cases,breast deformation may occur.This disease is rarely reported in Chinese people and has a high clinical misdiagnosis rate due to the absence of specific imaging features.On July 25,2022,a patient with a GJF was admitted to the First Affiliated Hospital of Dali University.The preoperative clinical examination and conventional ultrasound diagnosis needed further clarification.The mass was shown to be an atypical lobulated mass during the operation and confirmed to be a GJF based on pathologic examination.CONCLUSION GJF is also a rare,benign breast tumor in Chinese women.Evaluation of such masses consists of a physical examination,radiography,ultrasonography,computer tomography,and magnetic resonance imaging.GJFs are confirmed by histopathologic examination.Mastectomy is not selected when the patient benefits from a complete resection of the mass with breast reconstruction and an uneventful recovery.

康柏西普玻璃体腔注射联合EX-PRESS青光眼引流器植入治疗NVG

目的:观察康柏西普玻璃体腔注射应用EX-PRESS青光眼引流器植入治疗新生血管性青光眼的疗效。方法:选择2015-01/2018-01在我院眼科就诊的新生血管性青光眼患者37例37眼,随机分为试验组与对照组,两组在术前均行康柏西普玻璃体腔注射,试验组和对照组分别选择EX-PRESS青光眼引流器植入术和小梁切除术。对比两组术后成功率、最佳矫正视力、眼压、滤过泡、并发症。结果:术后12mo,两组手术成功率、BCVA及滤过泡率均无差异(P>0.05)。两组不同时间点眼压比较有差异(F组间=10.0,P组间=0.003;F时间=496.27,P时间<0.0001)。所有并发症经对症处理后改善。结论:EX-PRESS青光眼引流器植入联合康柏西普玻璃体腔注射治疗新生血管性青光眼对降低眼压、减少术后并发症有一定的临床价值。

Wear and corrosion resistance of laser-cladded Fe-based composite coatings on AISI 4130 steel

The wear and corrosion resistance of Fe_（72.2）Cr_（16.8）Ni_（7.3）Mo_（1.6）Mn_（0.7）C_（0.2）Si_（1.2） and Fe_（77.3）Cr_（15.8）Ni_（3.9）Mo_（1.1）Mn_（0.5）C_（0.2）Si_（1.2） coatings laser-cladded on AISI 4130 steel were studied.The coatings possess excellent wear and corrosion resistance despite the absence of expensive yttrium,tungsten,and cobalt and very little molybdenum.The microstructure mainly consists of dendrites and eutectic phases,such as duplex（γ＋α）-Fe and the Fe–Cr（Ni）solid solution,confirmed via energy dispersive spectrometry and X-ray diffraction.The cladded Fe-based coatings have lower coefficients of friction,and narrower and shallower wear tracks than the substrate without the cladding,and the main wear mechanism is mild abrasive wear.Electrochemical test results suggest that the soft Fe_（72.2）Cr_（16.8）Ni_（7.3）Mo_（1.6）Mn_（0.7）C_（0.2）Si_（1.2） coating with high Cr and Ni concentrations has high passivation resistance,low corrosion current,and positive corrosion potential,providing a better protective barrier layer to the AISI 4130 steel against corrosion.

Local inhomogeneity of mechanical properties in stir zone of friction stir welded AA1050 aluminum alloy

The local inhomogeneity of the stir zone in friction stir welded face-centered cubic metal was investigated,which has multiple activated slip systems during plastic deformation,by selecting commercial AA1050 aluminum alloy as an ideal experimental material.The local inhomogeneity was evaluated by uniaxial tensile tests using small samples with a 1 mm gauge length.The corresponding microstructural parameters such as grain size,misorientation angle distribution,and micro-texture,were quantified by the backscattered electron diffraction technique.A comprehensive model was used to reveal the microstructure−mechanical property relationship.The experimental results showed that the uniaxial tensile property changes significantly across the weld.The maximum ultimate tensile strength(UTS)occurred in the center of the stir zone,which was 99.0 MPa.The weakest regions were located at the two sides of the stir zone.The largest difference value in UTS reached 14.9 MPa,accounting for 15%of the maximum UTS.The analysis on the structure−mechanical property relationship suggests that the micro-texture change with the location formed during the rotational material flow is the main reason for the local inhomogeneity.

Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells

AIM To investigate the effects of combined use of emodin and baicalein(CEB) at the cellular and organism levelsin severe acute pancreatitis(SAP) and explore the underlying mechanism.METHODS SAP was induced by retrograde infusion of 5% sodium taurocholate into the pancreatic duct in 48 male SD rats. Pancreatic histopathology score, serum amylase activity, and levels of tumour necrosis factor alpha(TNf-α), interleukin 6(IL-6), and IL-10 were determined to assess the effects of CEB at 12 h after the surgery. The rat pancreatic acinar cells were isolated from healthy male SD rats using collagenase. The cell viability, cell ultrastructure, intracellular free Ca2+ concentration, and inositol(1,4,5)-trisphosphate receptor(IP3 R) expression were investigated to assess the mechanism of CEB.RESULTS Pancreatic histopathology score(2.07 ± 1.20 vs 6.84 ± 1.13, P < 0.05) and serum amylase activity(2866.2 ± 617.7 vs 5241.3 ± 1410.0, P < 0.05) were significantly decreased in the CEB(three doses) treatment group compared with the SAP group(2.07 ± 1.20 vs 6.84 ± 1.13, P < 0.05). CEB dose-dependently reduced the levels of the pro-inflammatory cytokines IL-6(466.82 ± 48.55 vs 603.50 ± 75.53, P < 0.05) and TNF-α(108.04 ± 16.10 vs 215.56 ± 74.67, P < 0.05) and increased the level of the anti-inflammatory cytokine IL-10(200.96 ± 50.76 vs 54.18 ± 6.07, P < 0.05) compared with those in the SAP group. CEB increased cell viability, inhibited cytosolic Ca2+ concentration, and significantly ameliorated intracellular vacuoles and IP3 m RNA expression compared with those in the SAP group(P < 0.05). There was a trend towards decreased IP3 R protein in the CEB treatment group; however, it did not reach statistical significance(P > 0.05).CONCLUSION These results at the cellular and organism levels reflect a preliminary mechanism of CEB in SAP and indicate that CEB is a suitable approach for SAP treatment.

The value of serum metabolomics analysis in predicting the response to cardiac resynchronization therapy

Objective To construct a prediction model based on metabolic profiling for predicting the response to cardiac resynchronization therapy(CRT).Methods Peripheral venous(PV)and coronary sinus(CS)blood samples were collected from 25 patients with heart failure(HF)at the time of CRT implantation,and PV blood samples were obtained from ten healthy controls.The serum samples were analyzed by liquid chromatography-mass spectrometry(LC-MS).As per the clinical and echocardiographic assessment at the 6-month follow-up,the HF patients were categorized as CRT responders and non-responders.Results HF patients had altered serum metabolomic profiles that were significantly different from those of the healthy controls.Differential metabolites were also observed between CRT responders and non-responders.A prediction model for CRT response(CRT-Re)was constructed using the concentration levels of the differential metabolites,L-arginine and taurine.The optimal cutoff value of the CRT-Re model was found to be 0.343 by ROC analysis(sensitivity,88.2%;specificity,87.5%;Area under curve(AUC)=0.897,P=0.002).The concentration levels of the differential metabolites,L-arginine and lysyl-gamma-glutamate,in PV serum were significantly correlated with that in CS serum(r=0.945 and 0.680,respectively,all P<0.001).Conclusions Our results suggest that serum-based metabolic profiling may be a potential complementary screening tool for predicting the outcome of CRT.

Dual-wavelength dual-indicator catalytic kinetic spectrophotometry for determination of trace Ru(Ⅲ)

A new dual-wavelength dual-indicator catalytic kinetic spectrophotometric method for the determination of trace Ru(III)was studied.This method was based on Ru(III)-catalyzing oxidation of Arsenazo I and indigo carmine by potassium bromate in sulfuric acid.The absorbances of the catalytic and noncatalytic systems were measured at 510 and610 nm,respectively.Under the optimum conditions,the linear range of determination is 0–0.12 lgáml-1and the detection limit is 1.21 9 10-4lgáml-1.The method was applied for the determination of trace Ru(III)in ore samples with satisfactory results.

Microstructure and properties of honeycomb composite films containing Eu and Sn

Honeycomb composite films were prepared by breath figure method via a straightforward,one-step process by doping complex containing Eu or Sn into polystyrene-b-poly(acrylic acid) solution.Several key influencing factors,such as the concentration of the block polymer solution,the relative humidity of the environment and the amount of complexes,were investigated to control micropore size and tune film surface properties.The characteristics of the composite films were studied by scanning electron microscopy(SEM),atomic force microscopy(AFM),X-ray diffraction(XRD),ultraviolet and emission spectra.Results indicate that composite films containing Eu have excellent optical performance,and micro-patterned bowl-like SnO_(2) microparticles could be fabricated from composite films containing Sn after being calcined at 600℃ for 5 h.This general approach for the fabrication of honeycomb composite films opens a convenient and effective route to the functional modification of honeycomb films and offers new prospects for the application in miniaturized sensors,micro-reactor and catalysis.

Synthesis of anatase TiO_(2) with exposed {001} and {101} facets and photocatalytic activity

Anatase titanium(IV)oxide(TiO_(2))particles with exposed{001}and{101}facets were prepared by hydrothermal treatment of amorphous TiO_(2) with H_(2)O_(2)-NH_(3) solution.Crystal phase,shape,and size of TiO_(2) particles are found to be greatly dependent on the ratio of H_(2)O_(2)-NH_(3) solution.The prepared TiO_(2) particles with specific exposed crystal faces show higher photocatalytic activity for acetaldehyde decomposition than commercial spherical TiO_(2) particles.This result implies that recombination is prevented by spatial separation of redox sites in the particles because of selective migration of electrons and positive holes to specific exposed crystal faces and/or different reactivity of electrons and positive holes on the specific exposed crystal face.

Improvement of photocatalytic activity of high specific surface area graphitic carbon nitride by loading a co-catalyst

Graphitic carbon nitride(g-C3N4)was synthesized by heating melamine and was then treated with sodium hydroxide solution under a hydrothermal condition to obtain g-C3N4 with a large specific surface area(HSSA).HSSA shows higher photocatalytic activity for decomposition of acetaldehyde than that of original g-C3N4.HSSA was modified with RuO2 as a co-catalyst by the impregnation method.HSSA loaded with 0.05 wt%RuO2 shows the highest photocatalytic activity for acetaldehyde decomposition under visible light(k=455 nm).

Radial Distribution Characteristics of Microstructure and Mechanical Properties of Ti–6Al–4V Butt Joint by Rotary Friction Welding

Ti-6Al-4V rods were butt-welded by rotary friction welding in this study. Additionally, the radial differences in microstructure and mechanical property of joints were investigated by hierarchy slicing method. The results displayed that the width of weld zone and heat-affected zone of joints became wider along radial direction. Meanwhile, the tensile strength of joints decreased gradually along the radial direction. According to the theoretical analysis, the temperature gradient and inhomogeneous forging pressure leaded to the radial differences. Through K-type thermocouples, the actual temperatures at different locations were measured, and the results were consistent with the theoretical analysis. Theoretically, the radial differences of rotary friction welding joint are an inherent phenomenon; thus, the size of weldment should be limited strictly below the corresponding critical size. In order to prevent radial differences from enlarging, the welding surface profile of weldment can be processed into oval shape, and a larger forging pressure can be used within the scope of the joint deformation allowed according to causes for radial differences.

Corrosion behavior of Ni-based coating containing spherical tungsten carbides in hydrochloric acid solution

A Ni-based alloy coating with 30 wt.%spherical fungsten carbide particles was prepared through plasma transferred arc welding on 42CrMo steel.The composition and microstructure of the coati ng were examined through X-ray diffraction and scanning electron microscopy with energy-dispersive spectrometry.The corrosion behaviors of the coating compared to the Ni coating without tungsten carbide particles and to the bare substrate in a0.5 mol/L HC1 solution were presented through polarization curves,electrochemical impedance spectroscopy(EIS)measurements and long-term immersion tests.The results demonstrated that the composite coating microstructure comprised Ni matrix,Ni-rich phase,tungsten carbide particles,W-rich phase and Cr-rich phase.The polarization curves and EIS measurements presented that a passivation film,which mainly included Ni,Cr,Fe and W oxides,was formed in the composite coating that protected the substrate from corrosion by HC1 solution.In the immersion tests,a micro-galvanic reaction at the new-formed phases and Ni matrix interface caused severe pit corrosion and Ni matrix consumption.The debonding of Ni-rich and W-rich phases could be observed with the immersion time extension.The tungsten carbide particles and Cr-rich phase were still attached on the surface for up to 30 days.

Sunitinib mesylate inhibits proliferation of human colonic stromal fibroblasts in vitro and in vivoSunitinib mesylate inhibits proliferation of human colonic stromal fibroblasts in vitro and in vivo

Objective： Cancer stromal fibroblasts are important members of the cancer microenvironment. In this study, we determined the effect of sunitinib, a small molecule tyrosine kinase inhibitor, on the primary human colonic fibroblasts. Methods： Cell cycle analysis and cell proliferation assays were performed to evaluate the inhibitory effect of sunitinib in vitro. Western-blot analysis was performed to evaluate variations in the levels of phosphorylated plateletderived growth factor receptor β （PDGFR-β）, Akt, and ERK proteins. Co-injection of SW620 cells and colonic fibreblasts in nude mice was employed to test anti-growth efficacy in vivo. Results： Sunitinib was found to effectively inhibit the growth of primary colonic fibroblasts. Low-dose sunitinib blocked the PDGF-BB-induced cell proliferation and PDGFR-β signaling. Co-injection of SW620 cells and colonic fibroblasts in nude mice generated greater tumor volumes than single injection of SW620 cells. Sunitinib treatment inhibited the SW620 cell＋colonic fibroblast tumor growth more effectively than treatment of 5-fluorouracil. Conclusions： Sunitinib mesylate inhibited the proliferation of primary human colonic fibroblasts through target-inhibited PDGFR signaling in vitro and in vivo.