BACKGROUND Acute gastric volvulus represents a rare form of surgical acute abdomen,which makes it difficult to establish an early diagnosis.As the disease progresses,it can lead to gastric ischemia,necrosis,and other ...BACKGROUND Acute gastric volvulus represents a rare form of surgical acute abdomen,which makes it difficult to establish an early diagnosis.As the disease progresses,it can lead to gastric ischemia,necrosis,and other serious complications.CASE SUMMARY This paper reports a 67-year-old female patient with a history of abdominal distension and retching for 1 day.After admission,a prompt and thorough exami-nation was performed to confirm the diagnosis of acute gastric volvulus.Notably,the patient had free air in the abdominal cavity.The first consideration was gastric volvulus with gastric perforation,but the patient had no complaints,such as abdominal pain or signs of peritoneal irritation in the abdomen,and imaging examination revealed no abdominal pelvic effusion.Following endoscopic reduc-tion,the abdominal organs,such as the stomach and spleen,returned to their normal anatomical positions,and the free intraperitoneal air disappeared,su-ggesting a rare case of acute gastric torsion.The source of free air within the abdominal cavity warrants careful consideration and discussion.Combined with the findings from computed tomography,these findings are hypothesized to be associated with the rupture of colonic air cysts.CONCLUSION Patients with gastric torsion combined with free gas in the abdominal cavity should consider nongastrointestinal perforation factors to avoid misdiagnosis.展开更多
A series of FTS/salicylic acid hybrids was designed and synthesized and their in vitro antitumor activities were evaluated.It was found that the anti-proliferation activities of hybrids were better than that of FTS.Co...A series of FTS/salicylic acid hybrids was designed and synthesized and their in vitro antitumor activities were evaluated.It was found that the anti-proliferation activities of hybrids were better than that of FTS.Compound 10 a displayed the strongest antitumor activities with IC50 values of 5.72-9.76 μmol/L and selectively inhibited tumor cell proliferation.In addition,10 a induced tumor cell apoptosis in a dosedependent manner by up-regulating the expression of Bax and caspase-3 and down-regulating Bcl-2.Our findings suggest that these novel hybrids may hold a great promise as therapeutic agents for the intervention of human cancers.展开更多
Long-range ordered nanostructures are prepared in the poly（styrene）-block-poly（e-caprolactone） diblock copolymer thin films using micromolding. We evaluated the change in crystallinity based on grazing-incidence X...Long-range ordered nanostructures are prepared in the poly（styrene）-block-poly（e-caprolactone） diblock copolymer thin films using micromolding. We evaluated the change in crystallinity based on grazing-incidence X-ray diffraction and proved that the crystallinity increased with the decrease of the mold size. This means that ordered nanostructures with atomic length scale order can be adjusted by tuning the mesoscale confinement. The inherent mechanism was the cooperation of geometric confinement, microphase structure and surface-induced ordering of PS-b-PCL in the melt, which paved the way for the subsequent crystal growth. These findings establish a route to promote the cost-effective nanofabrication by combining the mature microfabrication technique with the emerging directed self-assembly of block copolymers.展开更多
文摘BACKGROUND Acute gastric volvulus represents a rare form of surgical acute abdomen,which makes it difficult to establish an early diagnosis.As the disease progresses,it can lead to gastric ischemia,necrosis,and other serious complications.CASE SUMMARY This paper reports a 67-year-old female patient with a history of abdominal distension and retching for 1 day.After admission,a prompt and thorough exami-nation was performed to confirm the diagnosis of acute gastric volvulus.Notably,the patient had free air in the abdominal cavity.The first consideration was gastric volvulus with gastric perforation,but the patient had no complaints,such as abdominal pain or signs of peritoneal irritation in the abdomen,and imaging examination revealed no abdominal pelvic effusion.Following endoscopic reduc-tion,the abdominal organs,such as the stomach and spleen,returned to their normal anatomical positions,and the free intraperitoneal air disappeared,su-ggesting a rare case of acute gastric torsion.The source of free air within the abdominal cavity warrants careful consideration and discussion.Combined with the findings from computed tomography,these findings are hypothesized to be associated with the rupture of colonic air cysts.CONCLUSION Patients with gastric torsion combined with free gas in the abdominal cavity should consider nongastrointestinal perforation factors to avoid misdiagnosis.
基金the Natural Science Foundation of China(No.81302628)Jiangsu Province(No.BK2011389)+1 种基金China Pharmaceutical University for the Open Project Program of State Key Laboratory of Natural Medicines(No.SKLNMKF201415) for the financial supporta project funded by the Priority Academic Programs Development(PAPD) of Jiangsu Higher Education Institutions
文摘A series of FTS/salicylic acid hybrids was designed and synthesized and their in vitro antitumor activities were evaluated.It was found that the anti-proliferation activities of hybrids were better than that of FTS.Compound 10 a displayed the strongest antitumor activities with IC50 values of 5.72-9.76 μmol/L and selectively inhibited tumor cell proliferation.In addition,10 a induced tumor cell apoptosis in a dosedependent manner by up-regulating the expression of Bax and caspase-3 and down-regulating Bcl-2.Our findings suggest that these novel hybrids may hold a great promise as therapeutic agents for the intervention of human cancers.
基金financially supported by the National Natural Science Foundation of China(Nos.21274148 and 21074135)The experimental setup at the Nanofocus Endstation of MiNaXS was funded by the German Federal Ministry of Education and Research(projects BMBF 05KS7FK1 and 05K10FK3)
文摘Long-range ordered nanostructures are prepared in the poly（styrene）-block-poly（e-caprolactone） diblock copolymer thin films using micromolding. We evaluated the change in crystallinity based on grazing-incidence X-ray diffraction and proved that the crystallinity increased with the decrease of the mold size. This means that ordered nanostructures with atomic length scale order can be adjusted by tuning the mesoscale confinement. The inherent mechanism was the cooperation of geometric confinement, microphase structure and surface-induced ordering of PS-b-PCL in the melt, which paved the way for the subsequent crystal growth. These findings establish a route to promote the cost-effective nanofabrication by combining the mature microfabrication technique with the emerging directed self-assembly of block copolymers.
