Axonal mRNA localization and local translation in neurodegenerative diseases

The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function.Many human neurodegenerative diseases,such as fragile X syndrome,amyotrophic lateral sclerosis,Alzheimer’s disease,and spinal muscular atrophy,have been characterized by pathological changes in neuronal axons,including abnormal mRNA translation,the loss of protein expression,or abnormal axon transport.Moreover,the same protein and mRNA molecules have been associated with variable functions in different diseases due to differences in their interaction networks.In this review,we briefly examine fragile X syndrome,amyotrophic lateral sclerosis,Alzheimer’s disease,and spinal muscular atrophy,with a focus on disease pathogenesis with regard to local mRNA translation and axon transport,suggesting possible treatment directions.

A Comparative Research of Two English Translations of the Chapter “Comprehensive Discourse on Phenomena Corresponding to Yin and Yang” in Huangdi's Internal Classic

Culture-loaded words refer to words with specific cultural connotations that can express an abstract or a specific concept,which may be related to religious beliefs or social customs,but do not exist in other languages and cultures.Therefore,culture-loaded words bring some difficulties to translation work.Huang Di Nei Jing(《黄帝内经》Huangdi’s Internal Classic)is the foundation of traditional Chinese medicine(TCM)theory,and is listed as the first of the four classics of TCM.It contains a large number of cultureloaded words,which embody the ancient Chinese traditional culture.The translation of culture-loaded words is a difficult but crucial point in the translation of Huangdi’s Internal Classic and directly relates to the quality of the translation of Huangdi’s Internal Classic as a whole.Taking the two English versions of Maoshing Ni and Li Zhaoguo as examples,this work identifies the culture-loaded words appearing in the chapter“Yin Yang Ying Xiang Da Lun”(阴阳应象大论Comprehensive Discourse on Phenomena Corresponding to the Yin and Yang).This work studies the strategies and translation process of culture-loaded words in Huangdi’s Internal Classic,with a view to contribute to the English translation of TCM classics.

The Introduction and Localisation of Traditional Chinese Medicine in Malaysia

This thesis discusses how traditional Chinese medicine was introduced to Malaysia.History records show that traditional Chinese medicine was first introduced to Malaysia in the year 1405 while 1796 saw the establishment of Malaysia's first Chinese medicine shop.With the popularization of Chinese medicine,Chinese medicine education and organizations were established.Traditional Chinese Medicine has gradually been recognized by the Malaysian government due to the efforts of the practitioners of traditional Chinese medicine.In 2004,the Traditional and Complementary Medicine Department was established at the prestigious National Cancer Institute to improve quality of life as well as provide opportunities for cure to cancer patients.

Interview with Dr. Liu Qingquan: Traditional Chinese Medicine for COVID-19 Diagnosis and Treatment

To many of us,2020 was a remarkably difficult and challenging year.The whole world experienced a sudden,unexpected outbreak of COVID-19.According to the Zhong Guo Yi Bing Shi Jian(《中国疫病史鉴》History of Epidemics in China),there have been a total of 321 pandemics throughout the history of China ever since the Western Han dynasty(202 BCE–8 CE).

Study of Linearization of Hill Dose-Effect Curve with Metabolic Velocity Instead of Drug Concentration

Objective To explore the velocity-effect relationship in order to the establish linearization of effect on an equation with regard to the consistency of the Hill dose-effect expression with the metabolic kinetics of receptors.Methods The linear velocity-effect expression was obtained by solving multivariant differential equation groups,which were established to compare the coincidences and basic relations between the Hill dose-effect and metabolic kinetic Michaelis-Menten equation for receptors.The validation test was conducted with acetylcholine,adrenaline,and their mixture as model drugs.Results The linear velocity-effect modelling was represented in vivo or in vitro,for single and multidrug systems.Pharmacodynamic parameters,especially suitable for multicomponent CMM formulas,could be determined and calculated for single or multicomponent formulas at high saturating or low linear concentration for receptors.The validation test showed that the pharmacodynamic parameters of acetylcholine were:k,2.675×10^-3s^-1;ka,5.786×10^-9s^-1;km,2.500×10^-7s^-1;α,4.619×10^9张s·mg^-1;E0,13张(P<0.01)and those of adrenaline were:k,1.415×10^-3s^-1;ka,5.846×10^-9s^-1;km,2.300×10^-7s^-1;α,-1.627×10^9张s·m g^-1;E0,9.2张(P<0.01).For the mixture of the two components,the values were:α,1.375×1010张s·m g^-1;-6.150×10^9张s m g^-1for acetylcholine and adrenaline,respectively,and E0was7.08张in both,with the other parameters unchanged(P<0.01).Conclusion The velocity-effect equation can linearize the Hill dose-effect relationship,which can be applied to study the pharmacodynamics and availability of CMM formulations in vivo and in vitro.

泰它西普在IgA肾病和狼疮性肾炎中的研究进展

B淋巴细胞刺激因子(BLys)及其同源物增殖诱导配体(APRIL)在自身免疫性肾病发病机制中起着重要作用。泰它西普是通过重组DNA技术将BLys受体TACI胞外特定的可溶部分与人IgG1 Fc段融合的蛋白,可以阻断BLys和APRIL与其细胞膜受体(TACI、BR3、BCMA)之间的相互作用,从而实现阻断BLys和APRIL的生物学作用。该文阐述了泰它西普的作用机制及其在IgA肾病、狼疮性肾炎中的疗效及其安全性和耐受性,提示泰它西普为临床治疗自身免疫性肾病提供了新的思路和方向。

Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats

Objective:To observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats.Methods:All rats were randomly divided into normal control group,cirrhosis and treatment group.Thioacetamide was used to establish rat model of cirrhotic portal hypertension.The necrotic tissue of gastric mucosa ulcer focus,degree of neutrophils infiltration at the ulcer margin,portal pressure,portal venous flow,abdominal aortic pressure,abdominal aortic blood flow at front end,gastric mucosal blood flow（GMBF）,glycoprotein（GP）of gastric mucosa,basal acid secretion,H’ back-diffusion,gastric mucosal damage index,NO,prostaglandin E2（PGE2） and tumor necrosis factor-α（TNF-α） were determined respectively,and the pathological changes of gastric mucosa were also observed by microscope.Results:Compared with cirrhosis group and the control group,the ulcer bottom necrotic material,gastric neutrophil infiltration and UI of the treatment group were all decreased significantly（P【0.01）,GMBF value,GP values,serum NO,PGE2,TNF- a were all significantly increased.Conclusions:Omeprazole has an important protective effect on gastric mucosal and it can increase gastric mucosal blood flow and related to many factors.

Extraordinary transmission and reflection in PT-symmetric two-segment-connected triangular optical waveguide networks with perfect and broken integer waveguide length ratios

By adjusting the waveguide length ratio, we study the extraordinary characteristics of electromagnetic waves propagating in one-dimensional(1D) parity-time-symmetric(PT-symmetric) two-segment-connected triangular optical waveguide networks with perfect and broken integer waveguide length ratios respectively. It is found that the number and the corresponding frequencies of the extremum spontaneous PT-symmetric breaking points are dependent on the waveguide length ratio. Near the extremum breaking points, ultrastrong extraordinary transmissions are created and the maximal can arrive at, respectively, 2.4079 × 10^14 and 4.3555 × 10^13 in both kinds of networks. However, bidirectional invisibility can only be produced by the networks with broken integer waveguide length ratio, whose mechanism is explained in detail from the perspective of photonic band structure. The findings of this work can be useful optical characteristic control in the fabrication of PT-symmetric optical waveguide networks, which possesses great potential in designing optical amplifiers,optical energy saver devices, and special optical filters.

Comparison of three kinds of polarized Bessel vortex beams propagating through uniaxial anisotropic media

A comparison of differently polarized Bessel vortex beams propagating through a uniaxial anisotropic slab is discussed in terms of the vector wave function expansions.The magnitude profiles of electric field components, the transformation of polarization modes, and the distributions of orbital angular momentum(OAM) states of the reflected and transmitted beams for different incident angles are numerically simulated.The results indicate that the magnitude profiles of electric field components for different polarization modes are distinct from each other and have a great dependence on the incident angle,thus the transformation of polarization modes which reflects the change of energy can be affected largely.As compared to the x and circular polarization incidences, the reflected and transmitted beams for the radial polarization incidence suffer the fewest transformation of polarization modes, showing a better energy invariance.The distributions of OAM states of the reflected and transmitted beams for different polarization modes are diverse as well, and the derived OAM states of the transmitted beam for radial polarization present a focusing effect, concentrating on the state between two predominant OAM states.

Constructing a 3D multichannel structure to enhance performance of Ni–Co–Mn hydroxide electrodes for flexible supercapacitors

The balancing of the electrochemical performance,mechanical stability,and processing technology for applying supercapacitors to flexible and wearable electronics continues to encounter severe challenges.Herein,we prepare Ni-Co-Mn hydroxide electrodes with a threedimensional multichannel structure via a simple hydrothermal method.These are constructed using vertically contiguous nano sheets with a uniform thickness and rough surface.The electrodes can provide numerous electroactive sites and accelerate the transmission of electrolyte ions.The relationship between the structure and electrochemical performances is verified by experiments and theoretical calculations.Two-dimensional(2D)planar and one-dimensional(1D)fiber electrodes are prepared using a flexible carbon cloth(CC)and carbon fiber(CF),respectively,as substrates.The assembled quasi-solid-state flexible asymmetric supercapacitor(FASC)with a twodimensional sandwich structure using NiCoMn-OH/CC as the electrode achieves a remarkable energy density of73.8 Wh·kg^(-1)at a power density of 1.03 kW·kg^(-1).The quasi-solid-state FASC with a 1D linear structure using NiCoMn-OH/CF as the electrode also attains a high energy density(12.9 Wh·kg^(-1)at a power density of0.75 W·kg^(-1)).Moreover,the electrochemical performances of the NiCoMn/CC//AC/CC and NiCoMn/CF//AC/CF FASCs are not disturbed at different bending angles(0°,45°,90°,135°and 180°),This indicates the superior flexibility of the devices.We also assemble a self-powered energy-harvesting storage system by integrating FASCs and commercial solar cells to verify its practicability.It displays sustainable development potential for energy storage.